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Context Info
Confidence 0.75
First Reported 2009
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 3.53
Pain Relevance 0.96

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plasma membrane (Psd) intracellular (Psd) cytoplasm (Psd)
Anatomy Link Frequency
spines 1
Brains 1
synapse 1
white matter 1
Psd (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate receptor 16 100.00 Very High Very High Very High
Endep 7 99.46 Very High Very High Very High
Pain 1 98.54 Very High Very High Very High
cva 5 94.70 High High
Analgesic 2 91.24 High High
withdrawal 1 82.60 Quite High
Central nervous system 38 80.96 Quite High
Inflammation 19 70.56 Quite High
Peripheral nerve injury 1 63.76 Quite High
GABAergic 61 61.76 Quite High
Disease Link Frequency Relevance Heat
Dementia 117 100.00 Very High Very High Very High
Primary Sclerosing Cholangitis 27 100.00 Very High Very High Very High
Sleep Disorders 19 100.00 Very High Very High Very High
Stroke 123 98.60 Very High Very High Very High
Pain 3 98.54 Very High Very High Very High
Frailty 2 96.14 Very High Very High Very High
Hemorrhage 3 94.70 High High
Cognitive Disorder 95 93.00 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 84 80.44 Quite High
Aphasia 3 77.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Overall, these findings indicate that a period of PSD can influence pain modulatory mechanisms, and that amitriptyline action is insufficient to reduce PSD-enhanced thermal sensitivity.
Localization (reduce) of PSD associated with pain, sleep disorders and endep
1) Confidence 0.75 Published 2009 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 19619573 Disease Relevance 1.09 Pain Relevance 0.71
The difference of prevalence of PSD among various studies depends on the study design (eg, nonprospective or nonconsecutive samples) and the population studied, eg. demographic characteristics (as age, gender, and ethnicity), criteria used for the diagnosis of dementia, clinical manifestations, the preexisting cognitive level, lesion-related and radiological-associated factors as exclusion of hemorrhage or recurrent stroke, white matter changes, presence of cerebral atrophy, vascular risk factors, the time interval between the stroke and the neuropsychological assessment and length of follow-up.1,4,7,8,12,30–33 In an exploratory effort, Tatemichi and colleagues7 reported PSD in 16% (116/726) of patients in a stroke cohort aged ?
Localization (reported) of PSD in white matter associated with cognitive disorder, dementia, stroke, frailty and cva
2) Confidence 0.41 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2695209 Disease Relevance 1.93 Pain Relevance 0.05
Brains from sets of PSC, PSD, and PSR animals that were run together during the deprivation/rebound part of the experiment were processed together for immunohistochemistry and ISH.

Localization (sets) of PSD in Brains associated with primary sclerosing cholangitis
3) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909908 Disease Relevance 0.10 Pain Relevance 0
First, we determined the instantaneous localization of each QD with respect to presumptive PSD labeled with these markers.
Spec (determined) Localization (localization) of PSD
4) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2901346 Disease Relevance 0 Pain Relevance 0.03
Localized to the postsynaptic membrane of spines is the postsynaptic density (PSD), a complex protein apparatus comprised of glutamate receptors, associated scaffold and cytoskeletal proteins, and signal transduction molecules.
Localization (Localized) of PSD in spines associated with glutamate receptor
5) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2844417 Disease Relevance 0 Pain Relevance 0.05
PSD1 was boiled for 5 min in 1% SDS (in 150 mm NaCl, 50 mm Tris, 5 mm EDTA, pH 7.2) and then diluted stepwise with 9 volumes of RIPA buffer lacking SDS (1% Triton, 1% deoxycholate, 150 mm NaCl, 10 mm Tris, 5 mm EDTA, 2 mm EGTA, 10 mm ?
Localization (diluted) of PSD1
6) Confidence 0.25 Published 2009 Journal Molecular & Cellular Proteomics : MCP Section Body Doc Link PMC2667352 Disease Relevance 0 Pain Relevance 0
Inside the synapse, proteasome-mediated proteolysis can regulate the internalization of glutamate receptors (Patrick et al., 2003) as well as the abundance of many PSD proteins (Ehlers, 2003; Bingol and Schuman, 2004).
Localization (internalization) of PSD in synapse associated with glutamate receptor
7) Confidence 0.18 Published 2010 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2901091 Disease Relevance 0 Pain Relevance 0.05
Secondary IP3-mediated calcium influxes are thought to play a role in LTP, however, prolonged synaptic depolarization and IP3-mediated signaling can also activate calpain proteases that can cleave PSD-95 which releases it from NMDAR (Lu et al. 2000).
Localization (releases) of PSD
8) Confidence 0.15 Published 2010 Journal J Neuroimmune Pharmacol Section Body Doc Link PMC2914283 Disease Relevance 0.41 Pain Relevance 0.08

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