INT161778

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Context Info
Confidence 0.51
First Reported 2003
Last Reported 2011
Negated 2
Speculated 2
Reported most in Body
Documents 13
Total Number 15
Disease Relevance 9.46
Pain Relevance 0.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

enzyme binding (Esr1) DNA binding (Esr1) protein complex (Esr1)
cytoplasm (Esr1) lipid binding (Esr1) nucleus (Esr1)
Anatomy Link Frequency
immune system 2
apoptotic cell 2
extracellular matrix 2
eosinophil 2
Esr1 (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 28 96.72 Very High Very High Very High
Hippocampus 15 93.72 High High
agonist 17 92.32 High High
rheumatoid arthritis 39 92.12 High High
ischemia 109 91.44 High High
methotrexate 101 89.28 High High
abdominal pain 1 83.68 Quite High
cerebral cortex 1 81.24 Quite High
cytokine 26 50.08 Quite High
Inflammation 47 34.88 Quite Low
Disease Link Frequency Relevance Heat
Hypoxia 292 100.00 Very High Very High Very High
Stress 122 100.00 Very High Very High Very High
Death 81 100.00 Very High Very High Very High
Apoptosis 73 100.00 Very High Very High Very High
Multiple Sclerosis 221 99.90 Very High Very High Very High
Echinococcosis 10 99.36 Very High Very High Very High
Cancer 377 98.96 Very High Very High Very High
Targeted Disruption 60 97.60 Very High Very High Very High
Hyperplasia 22 93.72 High High
Postmenopausal Osteoporosis 1 93.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
One exception was the effect on ER expression.
Regulation (effect) of Gene_expression (expression) of ER
1) Confidence 0.51 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1410776 Disease Relevance 1.28 Pain Relevance 0
In MCF-7CLU cells the changes in ERalpha expression are substantially reduced but not completely abrogated (Figure 4 panel B).
Regulation (changes) of Gene_expression (expression) of ERalpha
2) Confidence 0.38 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2856549 Disease Relevance 0.46 Pain Relevance 0
are expressed in both the immune system and the CNS [188,189,194,195], oestrogen receptor knock out mice have been used to show that the protective effect of oestrogen treatment (oestradiol and oestriol) in EAE was dependent upon the presence of ER?
Regulation (dependent) of Gene_expression (presence) of ER in immune system associated with targeted disruption, multiple sclerosis and central nervous system
3) Confidence 0.37 Published 2011 Journal Biol Sex Differ Section Body Doc Link PMC3022636 Disease Relevance 0.41 Pain Relevance 0.07
Diminished ER expression by tamoxifen treatment has previously been reported in a Wnt-1 model [21].
Regulation (reported) of Gene_expression (expression) of ER
4) Confidence 0.32 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1410776 Disease Relevance 1.03 Pain Relevance 0
Despite the high tissue selectivity of such compounds, and despite the fact that the actions observed in our study were ligand-independent, one has to be aware of the potentially deleterious actions of ER?
Regulation (aware) of Gene_expression (actions) of ER
5) Confidence 0.31 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2432036 Disease Relevance 0.33 Pain Relevance 0.14
Based on the above studies showing that both ER?
Regulation (Based) of Gene_expression (showing) of ER
6) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2866326 Disease Relevance 0.65 Pain Relevance 0.36
The expression of ER and PR is regulated by endocrine factors and by extracellular matrix components such as collagen IV or laminin [59].
Regulation (regulated) of Gene_expression (expression) of ER in extracellular matrix
7) Confidence 0.23 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC1868922 Disease Relevance 0.66 Pain Relevance 0
Taken together, these findings suggest that persistent ER stress may induce apoptotic cell death through the eIF2?
Spec (may) Regulation (through) of Gene_expression (stress) of ER in apoptotic cell associated with stress, apoptosis and death
8) Confidence 0.20 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2652022 Disease Relevance 1.10 Pain Relevance 0
These data suggest that during ER stress, p-eIF2?
Spec (suggest) Regulation (suggest) of Gene_expression (stress) of ER associated with stress
9) Confidence 0.20 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2652022 Disease Relevance 0.99 Pain Relevance 0
Raloxifene showed an intermediate effect on the levels of ER?
Regulation (effect) of Gene_expression (levels) of ER
10) Confidence 0.04 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC156658 Disease Relevance 0.11 Pain Relevance 0
The variable number of ER+ cells might indicate that in HUT the dysregulation of ER expression is incomplete and may be absent in some lesions, or apparent under certain conditions [13].
Regulation (dysregulation) of Gene_expression (expression) of ER
11) Confidence 0.03 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1563460 Disease Relevance 0.62 Pain Relevance 0
Furthermore, a correlation was detected between ECP levels and eosinophil rate, IgE and CRP levels of patients with CE (p = 0.01), while there was no correlation between ECP and ESR levels.
Neg (no) Regulation (correlation) of Gene_expression (levels) of ESR in eosinophil associated with echinococcosis
12) Confidence 0.03 Published 2009 Journal Mikrobiyol Bul Section Abstract Doc Link 19621614 Disease Relevance 0.60 Pain Relevance 0.08
Also, we did not find significant differences in CRP and ESR levels when we compared the subgroups of patients with ineffectiveness in the original and effectiveness in the re-employed course (CRP, P = 0.69; ESR, P = 0.18) or those experiencing ineffectiveness in both courses (CRP, P = 0.58; ESR, P = 0.89).
Neg (not) Regulation (differences) of Gene_expression (levels) of ESR
13) Confidence 0.03 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526609 Disease Relevance 0.08 Pain Relevance 0.07
Interactions among the effects of anoxia on Ca2+ clearance, mitochondrial Ca2+ buffering, and ER Ca2+ uptake
Regulation (effects) of Gene_expression (uptake) of ER associated with hypoxia
14) Confidence 0.03 Published 2008 Journal Journal of Neurophysiology Section Body Doc Link PMC2493471 Disease Relevance 0.49 Pain Relevance 0
Effects of anoxia on ER Ca2+ stores
Regulation (Effects) of Gene_expression (stores) of ER associated with hypoxia
15) Confidence 0.03 Published 2008 Journal Journal of Neurophysiology Section Body Doc Link PMC2493471 Disease Relevance 0.64 Pain Relevance 0

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