INT16178

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Context Info
Confidence 0.69
First Reported 1982
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 20
Total Number 29
Disease Relevance 8.67
Pain Relevance 1.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Clcn1) transmembrane transport (Clcn1)
Anatomy Link Frequency
Skeletal muscle 3
Myoblast 2
muscle tissue 1
muscle 1
brains 1
Clcn1 (Mus musculus)
Pain Link Frequency Relevance Heat
palliative 3 99.72 Very High Very High Very High
analgesia 3 99.48 Very High Very High Very High
Analgesic 7 99.32 Very High Very High Very High
Opioid 3 99.10 Very High Very High Very High
Kinase C 14 97.74 Very High Very High Very High
IPN 1 88.16 High High
antagonist 2 83.60 Quite High
Pain 13 78.48 Quite High
ketamine 21 53.56 Quite High
Paracetamol 4 50.00 Quite Low
Disease Link Frequency Relevance Heat
Adverse Drug Reaction 259 100.00 Very High Very High Very High
Vomiting 3 100.00 Very High Very High Very High
Congenital Anomalies 11 99.96 Very High Very High Very High
Targeted Disruption 76 99.62 Very High Very High Very High
Hypopituitarism 122 99.36 Very High Very High Very High
Glioma 133 98.88 Very High Very High Very High
Cancer 283 98.60 Very High Very High Very High
Brain Tumor 91 98.12 Very High Very High Very High
Nociception 1 95.20 Very High Very High Very High
Phobia 2 94.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mis-splicing and expression loss of CLCN1 protein in skeletal muscle is associated with myotonia in DM1 patients and mouse models [28, 29].
Gene_expression (expression) of CLCN1 in skeletal muscle associated with hypopituitarism
1) Confidence 0.69 Published 2010 Journal Current Chemical Genomics Section Body Doc Link PMC2874217 Disease Relevance 0.25 Pain Relevance 0
CLCN1 protein expression could only be detected in differentiated myotubes, and the expression level in DM1 myotubes was 43±1% of WT levels (determined across multiple experiments, relative to ?
Gene_expression (expression) of CLCN1 in myotubes
2) Confidence 0.69 Published 2010 Journal Current Chemical Genomics Section Body Doc Link PMC2874217 Disease Relevance 0.28 Pain Relevance 0
Lentivirus expressing MYOD or CLCN1-luc was produced by co-transfection of 10 µg MyoD/pTREautoR3 or CLCN1-luc/pLenti6/V5-D-TOPO DNA with RRE, REV and VSV-g packaging vectors (6.5 µg, 2.5 µg and 3.5 µg, respectively) into 293Tcells, and viral supernatant was harvested as described above.


Gene_expression (expressing) of CLCN1
3) Confidence 0.69 Published 2010 Journal Current Chemical Genomics Section Body Doc Link PMC2874217 Disease Relevance 0 Pain Relevance 0
0.01% of that in mature muscle tissue [54], we tested for CLCN1 protein expression levels in our immortalized WT and DM1 cell lines by Western blot (Fig. 3B).
Gene_expression (expression) of CLCN1 in muscle tissue
4) Confidence 0.69 Published 2010 Journal Current Chemical Genomics Section Body Doc Link PMC2874217 Disease Relevance 0.28 Pain Relevance 0
The effect of MBNL1 loss of function is reflected in Mbnl1 knockout mice that exhibit Skeletal muscle-specific chloride channel 1 (Clcn1), Cardiac troponin T (Tnnt2) and Skeletal troponin T (Tnnt3) splicing abnormalities characteristic of DM1 [16].
Gene_expression (splicing) of Skeletal muscle-specific chloride channel 1 in Skeletal muscle associated with targeted disruption and congenital anomalies
5) Confidence 0.60 Published 2010 Journal Current Chemical Genomics Section Body Doc Link PMC2874217 Disease Relevance 0.50 Pain Relevance 0
Lentivirus expressing MYOD or CLCN1-luc was produced by co-transfection of 10 µg MyoD/pTREautoR3 or CLCN1-luc/pLenti6/V5-D-TOPO DNA with RRE, REV and VSV-g packaging vectors (6.5 µg, 2.5 µg and 3.5 µg, respectively) into 293Tcells, and viral supernatant was harvested as described above.


Gene_expression (transfection) of CLCN1
6) Confidence 0.60 Published 2010 Journal Current Chemical Genomics Section Body Doc Link PMC2874217 Disease Relevance 0.06 Pain Relevance 0
The effect of MBNL1 loss of function is reflected in Mbnl1 knockout mice that exhibit Skeletal muscle-specific chloride channel 1 (Clcn1), Cardiac troponin T (Tnnt2) and Skeletal troponin T (Tnnt3) splicing abnormalities characteristic of DM1 [16].
Gene_expression (splicing) of Clcn1 in Skeletal muscle associated with targeted disruption and congenital anomalies
7) Confidence 0.60 Published 2010 Journal Current Chemical Genomics Section Body Doc Link PMC2874217 Disease Relevance 0.49 Pain Relevance 0
Myotonia has been attributed to reduced expression of Clcn1 due to the combined effects of a decrease in transcription from the Clcn1 gene and inclusion of alternative exon 7a, which includes a TGA stop codon that triggers non-sense mediated decay [76].
Gene_expression (expression) of Clcn1 associated with hypopituitarism
8) Confidence 0.56 Published 2008 Journal Current Genomics Section Body Doc Link PMC2694559 Disease Relevance 0.24 Pain Relevance 0
Thirteen mutations were identified in CLCN1 and five mutations were identified in SCN4A.
Gene_expression (identified) of CLCN1
9) Confidence 0.53 Published 2009 Journal Neuromuscul. Disord. Section Abstract Doc Link 18337100 Disease Relevance 0.64 Pain Relevance 0.08
Generation of Immortalized Myoblast and CLCN1-luc Cell Lines
Gene_expression (Generation) of CLCN1 in Myoblast
10) Confidence 0.53 Published 2010 Journal Current Chemical Genomics Section Body Doc Link PMC2874217 Disease Relevance 0.13 Pain Relevance 0
A panel of protein kinase B (PKB or AKT) and protein kinase C (PKC) inhibitors were screened in 384-well format for their ability to serve as a positive control by enhancing expression of the CLCN1-luc construct in DM1 myoblasts (data not shown), based on reports that CUGBP1 activation and phosphorylation is mediated by members of these kinase families [51, 56].
Gene_expression (expression) of CLCN1 in myoblasts associated with kinase c
11) Confidence 0.53 Published 2010 Journal Current Chemical Genomics Section Body Doc Link PMC2874217 Disease Relevance 0 Pain Relevance 0.05
Generation of CLCN1-luc Construct
Gene_expression (Generation) of CLCN1
12) Confidence 0.53 Published 2010 Journal Current Chemical Genomics Section Body Doc Link PMC2874217 Disease Relevance 0.23 Pain Relevance 0
In 12 patients the ADR was already present on hospital admission.
Gene_expression (present) of ADR associated with adverse drug reaction
13) Confidence 0.50 Published 1982 Journal Schweiz Med Wochenschr Section Abstract Doc Link 7178881 Disease Relevance 0.69 Pain Relevance 0.10
Diverse genes are consequently reduced in expression, including the muscle-specific chlorine channel 1 (CLCN1), which has been involved in myotonia [40].
Gene_expression (expression) of CLCN1 in muscle associated with hypopituitarism
14) Confidence 0.44 Published 2008 Journal Current Genomics Section Body Doc Link PMC2694559 Disease Relevance 0.10 Pain Relevance 0
In contrast, ADR-851R produced significant analgesia at 3 and 10 mg/kg doses in this test, while ADR-851S produced significant analgesia only at 1 mg/kg.
Gene_expression (produced) of ADR-851S associated with analgesia
15) Confidence 0.36 Published 1991 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1804661 Disease Relevance 0.18 Pain Relevance 0.61
In addition, due to the difficulty in recruiting participants, there was no time limit related to when the ADR was experienced.
Gene_expression (experienced) of ADR
16) Confidence 0.29 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2847952 Disease Relevance 0.07 Pain Relevance 0
Similarly, the main enablers to reporting were feeling comfortable with the person with whom they shared their ADR experience and knowing that one could or should report the ADR.
Gene_expression (experience) of ADR
17) Confidence 0.29 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2847952 Disease Relevance 0.35 Pain Relevance 0
ADR analysis
Gene_expression (analysis) of ADR
18) Confidence 0.25 Published 2005 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661606 Disease Relevance 0.32 Pain Relevance 0
In Trial 5 (Table 2 and Figure 6b), we showed that similar amounts of p97 as p97-ADR conjugates (SYN019 and SYN020) were transported into the brains of mice after tail vein injection.
Gene_expression (amounts) of ADR in brains
19) Confidence 0.24 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2424243 Disease Relevance 0.58 Pain Relevance 0
p97, Lf, and p97-ADR conjugates were iodinated using a standard chloramine T protocol [52].
Gene_expression (conjugates) of ADR
20) Confidence 0.24 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2424243 Disease Relevance 0 Pain Relevance 0

General Comments

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