INT161796

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Context Info
Confidence 0.21
First Reported 2004
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 2.23
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (ECE1) extracellular space (EDN1) peptidase activity (ECE1)
extracellular region (EDN1) plasma membrane (ECE1) cell-cell signaling (EDN1)
ECE1 (Homo sapiens)
EDN1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Serotonin 3 100.00 Very High Very High Very High
antagonist 58 76.44 Quite High
cytokine 2 70.32 Quite High
Central nervous system 2 52.24 Quite High
Angina 1 49.68 Quite Low
Neurotransmitter 2 17.12 Low Low
metalloproteinase 16 5.00 Very Low Very Low Very Low
Pain 12 5.00 Very Low Very Low Very Low
analgesia 4 5.00 Very Low Very Low Very Low
nociceptor 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 2 99.20 Very High Very High Very High
Increased Venous Pressure Under Development 3 98.16 Very High Very High Very High
Coronary Vasospasm 3 85.40 High High
Cancer 130 70.08 Quite High
Metastasis 26 66.64 Quite High
Apoptosis 32 64.56 Quite High
Hypoxia 18 63.92 Quite High
Stress 2 62.40 Quite High
Natriuresis 2 56.56 Quite High
Sarcoma 18 54.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The biologically active ET-1 is formed by endothelin-converting-enzyme (ECE), an enzyme with intracellular and membrane-bound isoforms [7].
ECE Binding (formed) of ET-1
1) Confidence 0.21 Published 2004 Journal J Transl Med Section Body Doc Link PMC436068 Disease Relevance 0.77 Pain Relevance 0.10
The biologically active ET-1 is formed by endothelin-converting-enzyme (ECE), an enzyme with intracellular and membrane-bound isoforms [7].
ECE Binding (formed) of ET-1
2) Confidence 0.21 Published 2004 Journal J Transl Med Section Body Doc Link PMC436068 Disease Relevance 0.77 Pain Relevance 0.10
The level of endothelin-converting enzyme was upregulated at that site where, upon exposure to serotonin, there were also increases in p47(phox), ROS, and ET-1 fluorescence intensities, and myosin light chain phosphorylation and RhoA activation were detected.
endothelin-converting enzyme Binding (intensities) of ET-1 associated with serotonin
3) Confidence 0.05 Published 2009 Journal Coron. Artery Dis. Section Abstract Doc Link 19623039 Disease Relevance 0.68 Pain Relevance 0.14

General Comments

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