INT1618

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Context Info
Confidence 0.37
First Reported 1979
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.01
Pain Relevance 1.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Gad1) lyase activity (Gad1) intracellular (Gad1)
cytoplasm (Gad1)
Anatomy Link Frequency
spinal cord 1
Purkinje cell 1
Gad1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
substance P 9 99.80 Very High Very High Very High
Enkephalin 1 99.20 Very High Very High Very High
gABA 65 98.72 Very High Very High Very High
Spinal cord 2 98.08 Very High Very High Very High
Dopamine 2 96.24 Very High Very High Very High
Sciatic nerve 3 96.00 Very High Very High Very High
dorsal rhizotomy 3 95.08 Very High Very High Very High
anesthesia 7 89.48 High High
Dorsal horn 4 82.88 Quite High
GABAergic 38 82.60 Quite High
Disease Link Frequency Relevance Heat
Generalized Anxiety Disorder 64 99.84 Very High Very High Very High
Dyskinesias 7 99.70 Very High Very High Very High
Syndrome 1 99.52 Very High Very High Very High
Convulsion 12 99.30 Very High Very High Very High
Dystonia 13 98.76 Very High Very High Very High
Movement Disorders 1 92.72 High High
Primary Sclerosing Cholangitis 27 67.52 Quite High
Cancer 1 25.04 Quite Low
Congenital Anomalies 1 25.00 Low Low
Sleep Disorders 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased glutamic acid decarboxylase activity, increased glucose utilization, and decreased muscimol binding within the cerebellar nuclei of the dystonic rat suggests that Purkinje cell firing rates are increased in these animals.
glutamic acid decarboxylase Binding (binding) of in Purkinje cell associated with dystonia
1) Confidence 0.37 Published 2002 Journal Exp Brain Res Section Abstract Doc Link 12172657 Disease Relevance 0.76 Pain Relevance 0.15
L-DOPA-induced dyskinesia in the rat is associated with striatal overexpression of prodynorphin- and glutamic acid decarboxylase mRNA.
glutamic acid decarboxylase Binding (associated) of associated with enkephalin and dyskinesias
2) Confidence 0.37 Published 1998 Journal Eur. J. Neurosci. Section Title Doc Link 9767399 Disease Relevance 0.31 Pain Relevance 0.21
The substance P content, glutamic acid decarboxylase and choline acetyltransferase activities and the level of [3H]diprenorphine binding were measured in various regions of the lumbar spinal cord of rats after unilateral section of the sciatic nerve or after dorsal rhizotomy.
glutamic acid decarboxylase Binding (binding) of in spinal cord associated with dorsal rhizotomy, sciatic nerve, spinal cord and substance p
3) Confidence 0.30 Published 1979 Journal Brain Res. Section Abstract Doc Link 221070 Disease Relevance 0 Pain Relevance 0.58
Immunohistochemistry of MCH combined with GAD67 mRNA in situ hybridization
GAD67 Binding (combined) of
4) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909908 Disease Relevance 0.12 Pain Relevance 0
Convulsions induced by methylmalonic acid are associated with glutamic acid decarboxylase inhibition in rats: a role for GABA in the seizures presented by methylmalonic acidemic patients?
glutamic acid decarboxylase Binding (associated) of associated with gaba and convulsion
5) Confidence 0.23 Published 2007 Journal Neuroscience Section Title Doc Link 17467181 Disease Relevance 0.64 Pain Relevance 0.25
For immunohistochemistry, immunocytochemistry and Western blot analyses we employed rabbit polyclonal antiserum against GAD, which recognizes both isoforms GAD65 and GAD67 (DPC Biermann, Bad Nauheim, Germany); rabbit polyclonal antiserum against VGAT (SySy Synaptic Systems GmbH, Göttingen, Germany); rabbit polyclonal antiserum against GABAA-?
GAD67 Binding (recognizes) of associated with generalized anxiety disorder
6) Confidence 0.20 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC416489 Disease Relevance 0.19 Pain Relevance 0.11

General Comments

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