INT16180

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Context Info
Confidence 0.53
First Reported 1991
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 4.63
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (DSPP) proteinaceous extracellular matrix (DSPP)
Anatomy Link Frequency
dentin 4
DSPP (Homo sapiens)
Pain Link Frequency Relevance Heat
anesthesia 2 98.92 Very High Very High Very High
Pain 12 88.72 High High
Inflammation 30 34.04 Quite Low
Inflammatory marker 2 5.00 Very Low Very Low Very Low
tolerance 1 5.00 Very Low Very Low Very Low
Angina 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Weight Loss 37 100.00 Very High Very High Very High
Dentin Sensitivity 4 100.00 Very High Very High Very High
Diabetes Mellitus 55 99.58 Very High Very High Very High
Congenital Anomalies 8 98.16 Very High Very High Very High
Hyperinsulinism 3 96.80 Very High Very High Very High
Body Weight 4 94.36 High High
Pain 12 88.72 High High
Shock 2 88.68 High High
Cleidocranial Dysplasia 114 86.32 High High
Insulin Resistance 14 86.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
DSPP is located within human chromosome 4q22.1 and consists of 5 exons spanning approximately 8343 bp [17]; however, see below for recent information regarding DSPP length polymorphisms affecting DPP.
Regulation (affecting) of DPP
1) Confidence 0.53 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2600777 Disease Relevance 1.22 Pain Relevance 0
DSPP is located within human chromosome 4q22.1 and consists of 5 exons spanning approximately 8343 bp [17]; however, see below for recent information regarding DSPP length polymorphisms affecting DPP.
Regulation (affecting) of DSPP
2) Confidence 0.39 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2600777 Disease Relevance 1.24 Pain Relevance 0
Many clinical problems such as poor dentin bonding, microleakage, dentin sensitivity, and pulpal irritation have a common denominator in the structure and function of dentin.
Regulation (sensitivity) of dentin in dentin associated with dentin sensitivity
3) Confidence 0.18 Published 1991 Journal J Prosthet Dent Section Abstract Doc Link 1805028 Disease Relevance 0.41 Pain Relevance 0.09
Many clinical problems such as poor dentin bonding, microleakage, dentin sensitivity, and pulpal irritation have a common denominator in the structure and function of dentin.
Regulation (sensitivity) of dentin in dentin associated with dentin sensitivity
4) Confidence 0.18 Published 1991 Journal J Prosthet Dent Section Abstract Doc Link 1805028 Disease Relevance 0.40 Pain Relevance 0.09
In the Diabetes Prevention Program (DPP) and the Finnish trials, lifestyle intervention including modest weight loss was effective in preventing the development of diabetes in a high risk population [15,16].
Regulation (effective) of DPP associated with weight loss and diabetes mellitus
5) Confidence 0.07 Published 2005 Journal Nutr Metab (Lond) Section Body Doc Link PMC1188071 Disease Relevance 1.22 Pain Relevance 0
The deeper zone, located towards the pulp, was called affected dentin, often referred to as secondary caries, being composed of fewer bacteria and demineralized dentin [53].
Regulation (affected) of dentin in dentin
6) Confidence 0.03 Published 2010 Journal International Journal of Dentistry Section Body Doc Link PMC2913523 Disease Relevance 0 Pain Relevance 0
The deeper affected carious dentin is generally 1,000 to 2,500 ?
Regulation (affected) of dentin in dentin
7) Confidence 0.03 Published 2010 Journal International Journal of Dentistry Section Body Doc Link PMC2913523 Disease Relevance 0.14 Pain Relevance 0.10

General Comments

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