INT161804

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Context Info
Confidence 0.39
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.83
Pain Relevance 0.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (ING1) cell cycle (ING1)
ING1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Serotonin 3 99.64 Very High Very High Very High
ketamine 10 99.48 Very High Very High Very High
Inflammatory stimuli 1 52.64 Quite High
Angina 1 46.00 Quite Low
Analgesic 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Injury 2 94.84 High High
Increased Venous Pressure Under Development 3 93.80 High High
Coronary Vasospasm 3 81.04 Quite High
Apoptosis 1 79.28 Quite High
INFLAMMATION 1 52.32 Quite High
Stress 1 51.64 Quite High
Variant Angina Pectoris 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, treatment with ketamine down-regulated both fMLP-induced p47(phox) and isoproterenol-induced p38 MAPK phosphorylation and superoxide production.
Positive_regulation (induced) of p47 associated with ketamine
1) Confidence 0.39 Published 2010 Journal Clin. Exp. Immunol. Section Abstract Doc Link 20345980 Disease Relevance 0.18 Pain Relevance 0.44
The level of endothelin-converting enzyme was upregulated at that site where, upon exposure to serotonin, there were also increases in p47(phox), ROS, and ET-1 fluorescence intensities, and myosin light chain phosphorylation and RhoA activation were detected.
Positive_regulation (increases) of p47 associated with serotonin
2) Confidence 0.08 Published 2009 Journal Coron. Artery Dis. Section Abstract Doc Link 19623039 Disease Relevance 0.65 Pain Relevance 0.13

General Comments

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