INT161807

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Context Info
Confidence 0.43
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 4.86
Pain Relevance 0.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (ROS1) cell proliferation (ROS1) plasma membrane (ROS1)
Anatomy Link Frequency
body 1
spermatozoa 1
ROS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Serotonin 7 99.16 Very High Very High Very High
Angina 2 82.16 Quite High
Fibrositis 58 80.72 Quite High
Inflammation 20 75.00 Quite High
Neurotransmitter 1 73.64 Quite High
depression 5 49.60 Quite Low
headache 4 48.16 Quite Low
chronic pain syndrome 2 45.92 Quite Low
cytokine 19 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 6 99.40 Very High Very High Very High
Apoptosis 69 98.92 Very High Very High Very High
Stress 83 97.76 Very High Very High Very High
Cancer 39 96.12 Very High Very High Very High
Toxicity 3 94.96 High High
Injury 5 93.88 High High
Coronary Vasospasm 6 92.64 High High
Obesity 11 91.20 High High
Myopia 41 89.32 High High
Endometroid Carcinoma 36 85.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The ability of ROS to enhance the tyrosine phosphorylation status of human spermatozoa depends partly on the ability of H2O2 to suppress tyrosine phosphatase activity, and partly on the ability of these molecules to stimulate cAMP generation by the soluble form of adenylyl cyclase (sAC) [16,17].
Phosphorylation (phosphorylation) of ROS in spermatozoa
1) Confidence 0.43 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1315356 Disease Relevance 0.36 Pain Relevance 0
The mitochondrial genome encodes the oxidative phosphorylation system where energy and ROS are generated [1].
Phosphorylation (phosphorylation) of ROS
2) Confidence 0.36 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2830021 Disease Relevance 0.43 Pain Relevance 0
However, HMW-HA had no significant effect on ROS and GSH levels, 8-oxo-dG release, and p53 phosphorylation.


Phosphorylation (phosphorylation) of ROS
3) Confidence 0.36 Published 2009 Journal Molecular Vision Section Abstract Doc Link PMC2660376 Disease Relevance 0.24 Pain Relevance 0.04
The mitochondria produce cellular energy by oxidative phosphorylation and generate reactive oxygen species (ROS) as a by-product.
Phosphorylation (phosphorylation) of ROS
4) Confidence 0.33 Published 2010 Journal Virchows Arch Section Body Doc Link PMC2852529 Disease Relevance 1.03 Pain Relevance 0
Cell viability, reactive oxygen species (ROS) and glutathione (GSH) levels, 8-hydroxy-2'-deoxyguanosine (8-oxo-dG) release, p53 phosphorylation, caspase-3, -8, -9 activation, and interleukin (IL)-6 and -8 production were assessed to evaluate and to compare UVB-induced toxicity between cells treated with HMW-HA and cells treated with PBS.


Phosphorylation (phosphorylation) of ROS associated with toxicity
5) Confidence 0.31 Published 2009 Journal Molecular Vision Section Abstract Doc Link PMC2660376 Disease Relevance 0.24 Pain Relevance 0.04
CoQ10 deficiency induces decreased activities of complex II + III, complex III and complex IV, reduced expression of mitochondrial proteins involved in oxidative phosphorylation, decreased mitochondrial membrane potential, increased production of reactive oxygen species (ROS), activation of mitochondrial permeability transition (MPT), mitophagy of dysfunctional mitochondria, and reduced growth rates [8,9].
Phosphorylation (phosphorylation) of ROS
6) Confidence 0.29 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875645 Disease Relevance 0.51 Pain Relevance 0.11
The chronic blockade of endothelin type-A receptor prevented a serotonin-triggered vasospasm along with the inhibition of ROS generation and myosin light chain phosphorylation.
Phosphorylation (phosphorylation) of ROS associated with increased venous pressure under development and serotonin
7) Confidence 0.24 Published 2009 Journal Coron. Artery Dis. Section Abstract Doc Link 19623039 Disease Relevance 0.63 Pain Relevance 0.21
The level of endothelin-converting enzyme was upregulated at that site where, upon exposure to serotonin, there were also increases in p47(phox), ROS, and ET-1 fluorescence intensities, and myosin light chain phosphorylation and RhoA activation were detected.
Phosphorylation (phosphorylation) of ROS associated with serotonin
8) Confidence 0.18 Published 2009 Journal Coron. Artery Dis. Section Abstract Doc Link 19623039 Disease Relevance 0.66 Pain Relevance 0.19
Improvement in whole-body oxygen consumption may therefore be expected to lower ROS production, a normal byproduct of oxidative phosphorylation.
Phosphorylation (phosphorylation) of ROS in body
9) Confidence 0.17 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1808482 Disease Relevance 0.27 Pain Relevance 0
Reactive oxygen species (ROS) are predominantly formed as a by-product of oxidative phosphorylation in the mitochondria [35] with at least 9 submitochondrial ROS-producing sites identified.
Phosphorylation (phosphorylation) of ROS
10) Confidence 0.16 Published 2010 Journal Biochim Biophys Acta Section Body Doc Link PMC2795853 Disease Relevance 0.48 Pain Relevance 0.04

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