INT161812

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Context Info
Confidence 0.56
First Reported 2001
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 17
Total Number 17
Disease Relevance 5.64
Pain Relevance 2.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (PER1) protein binding transcription factor activity (PER1) cytoplasm (PER1)
signal transducer activity (PER1)
Anatomy Link Frequency
urinary bladder 1
muscle 1
brain 1
muscle fiber 1
PER1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain threshold 4 99.96 Very High Very High Very High
transcutaneous nerve stimulation 16 99.86 Very High Very High Very High
sSRI 11 99.66 Very High Very High Very High
Pain 132 96.64 Very High Very High Very High
Transcranial magnetic stimulation 18 94.60 High High
Central nervous system 4 83.96 Quite High
Angina 6 81.32 Quite High
ischemia 11 78.72 Quite High
Neurotransmitter 13 77.52 Quite High
withdrawal 9 70.72 Quite High
Disease Link Frequency Relevance Heat
Malaria 113 99.98 Very High Very High Very High
Pain 113 99.96 Very High Very High Very High
Cramps 7 98.48 Very High Very High Very High
Injury 15 98.44 Very High Very High Very High
Infection 25 94.64 High High
Apnoea 54 94.28 High High
Cancer 12 94.12 High High
Acute Coronary Syndrome 6 93.88 High High
Constipation 15 90.92 High High
Malignant Neoplastic Disease 6 90.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
An interesting finding is that Per1 and Per2 are upregulated in the morning in hSkM (Figure 2), and downregulated in the morning in mSkM (Figure 3b).
Positive_regulation (upregulated) of Per1
1) Confidence 0.56 Published 2003 Journal Genome Biol Section Body Doc Link PMC328450 Disease Relevance 0 Pain Relevance 0
The significant upregulation of Per1 and Per2 in our diurnal comparison provided the first indication that the 608 genes that changed significantly with time contained known circadian-regulated genes.
Positive_regulation (upregulation) of Per1
2) Confidence 0.56 Published 2003 Journal Genome Biol Section Body Doc Link PMC328450 Disease Relevance 0.25 Pain Relevance 0
However, the incidence of falciparum malaria increased dramatically in Perú in the early 1990s, with a seven-fold increase of malaria incidence between 1990 and 1996 [4].
Positive_regulation (increased) of Per associated with malaria
3) Confidence 0.56 Published 2009 Journal Malar J Section Body Doc Link PMC2714521 Disease Relevance 0.91 Pain Relevance 0
However, resistance exercise protocols do not result in increases in capillaries per muscle area but do result in a redistribution of blood flow to hypertrophied muscle fiber types [4].
Positive_regulation (increases) of per in muscle fiber
4) Confidence 0.49 Published 2003 Journal Genome Biol Section Body Doc Link PMC328450 Disease Relevance 0 Pain Relevance 0
Two clusters contained core circadian genes Per1 (Figure 6a) and Per2 (Figure 6b) which were upregulated at 0800 hours.
Positive_regulation (upregulated) of Per1
5) Confidence 0.49 Published 2003 Journal Genome Biol Section Body Doc Link PMC328450 Disease Relevance 0 Pain Relevance 0
The stimulation frequency was increased from 4 pulses per second (pps) at increments of 2 pps until a cramp was induced.
Positive_regulation (increased) of pulses per second associated with cramps
6) Confidence 0.34 Published 2009 Journal Muscle Nerve Section Abstract Doc Link 19623637 Disease Relevance 0.43 Pain Relevance 0
PERSPECTIVE: This study provides evidence that high frequency TENS at 80 pulses per second increases pain threshold to pressure algometry in healthy participants over and above that seen with low frequency TENS at 3 pulses per second when a strong nonpainful TENS sensation is experienced within the site of experimental pain.
Positive_regulation (increases) of pulses per second associated with pain, pain threshold and transcutaneous nerve stimulation
7) Confidence 0.31 Published 2010 Journal J Pain Section Abstract Doc Link 19665936 Disease Relevance 0.81 Pain Relevance 1.69
Further, electrical stimulation of urinary bladder per se may have an effect on cell proliferation [8,9].
Positive_regulation (stimulation) of per se in urinary bladder
8) Confidence 0.17 Published 2008 Journal Cases J Section Body Doc Link PMC2546370 Disease Relevance 0.80 Pain Relevance 0
Specimens of T. rex were collected from two states of Perú in 1997; one from a health center in Lamas province, department of San Martin, Perú, and one from a local heath center in Yochegua province, San Francisco district.
Positive_regulation (department) of Per
9) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2854684 Disease Relevance 0 Pain Relevance 0
Specimens of T. rex were collected from two states of Perú in 1997; one from a health center in Lamas province, department of San Martin, Perú, and one from a local heath center in Yochegua province, San Francisco district.
Positive_regulation (department) of Per
10) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2854684 Disease Relevance 0 Pain Relevance 0
The presence of elevated cTn per se is not sufficient to diagnose cardiac injury [110,111].
Positive_regulation (elevated) of per se associated with injury
11) Confidence 0.05 Published 2008 Journal Crit Care Section Body Doc Link PMC2481437 Disease Relevance 1.25 Pain Relevance 0.20
1 induces only 5-LOX mRNA accumulation and not true upregulation of gene expression per se.
Neg (not) Positive_regulation (upregulation) of per se
12) Confidence 0.05 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0.05 Pain Relevance 0.03
While Cicaprost did not induce substantial RhoA activation per se in HEK.TP?
Neg (not) Positive_regulation (induce) of per se
13) Confidence 0.04 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0
Clinical efficacy after period 1
Positive_regulation (after) of period 1
14) Confidence 0.03 Published 2007 Journal Nutr J Section Body Doc Link PMC1852321 Disease Relevance 0.17 Pain Relevance 0.13
Thus we conclude that the effects of rTMS on visual discrimination performance for static stimuli are not a direct consequence of the stimulation protocol per se, but rather are specific to the targeted brain region.


Neg (not) Positive_regulation (consequence) of per se in brain
15) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2860988 Disease Relevance 0 Pain Relevance 0.08
In normal persons, Sunderram et al. [26] showed that the SSRI paroxetine both increased GG muscle activity per se and attenuated reflex GG muscle inhibition by positive airway pressure.
Positive_regulation (increased) of per se in muscle associated with ssri
16) Confidence 0.02 Published 2001 Journal Respir Res Section Body Doc Link PMC59518 Disease Relevance 0.23 Pain Relevance 0.23
Our message is not the need to increase GP consultations per se.
Positive_regulation (increase) of per se
17) Confidence 0.01 Published 2007 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1925074 Disease Relevance 0.74 Pain Relevance 0.58

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