INT16184

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Context Info
Confidence 0.53
First Reported 1990
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 20
Total Number 20
Disease Relevance 10.61
Pain Relevance 1.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (CHKB)
Anatomy Link Frequency
plasma 2
skeletal muscle 1
nodules 1
limbs 1
upper 1
CHKB (Homo sapiens)
Pain Link Frequency Relevance Heat
Angina 85 95.12 Very High Very High Very High
fibrosis 1 91.84 High High
cva 14 90.28 High High
tetrodotoxin 1 88.68 High High
anesthesia 1 86.44 High High
Inflammation 45 84.76 Quite High
imagery 7 84.28 Quite High
cocaine 5 70.48 Quite High
visual analogue scale 20 67.56 Quite High
cINOD 2 67.00 Quite High
Disease Link Frequency Relevance Heat
Rhabdomyolysis 9 99.86 Very High Very High Very High
Paralysis 5 99.72 Very High Very High Very High
Myocardial Infarction 138 99.58 Very High Very High Very High
Muscle Weakness 3 99.52 Very High Very High Very High
Pressure And Volume Under Development 15 99.48 Very High Very High Very High
Infarction 13 99.02 Very High Very High Very High
Myoglobinuria 3 97.80 Very High Very High Very High
Rupture 20 97.40 Very High Very High Very High
Myalgia 61 96.68 Very High Very High Very High
Acute Coronary Syndrome 149 96.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, this explanation is not supported by Ohtani et al. [18] who found that a small free form amino acid mixture (5.6 grams) ingested directly before and after eccentric exercise in both humans and animals lowered CK levels.
Negative_regulation (lowered) of CK
1) Confidence 0.53 Published 2008 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2288590 Disease Relevance 0.05 Pain Relevance 0
For those with elevated CK-MB, more than two times the upper limit of normal within 8 h after randomization, and with a decrease in CK-MB of more than 50% from the previous peak value, reinfarction was defined as an elevation of the value of CK-MB at or after 8 h to more than two times the upper limit of normal (three times in the case of PTCA) and 75% more than the preceding trough CK-MB values.
Negative_regulation (decrease) of CK-MB in upper
2) Confidence 0.48 Published 2000 Journal Curr Control Trials Cardiovasc Med Section Body Doc Link PMC56207 Disease Relevance 0.37 Pain Relevance 0.07
RESULTS: While IP significantly reduced CK-MB (18.7 +/- 1.3 vs. 13.8 +/- 1.5 U/L, mean +/- SEM, p < 0.05), it only tended to reduce CK (292.7 +/- 32.8 vs. 274.1+/-31.1 U/L, p = NS, mean +/- SEM).
Negative_regulation (reduced) of CK
3) Confidence 0.40 Published 2005 Journal J Card Surg Section Body Doc Link 16153270 Disease Relevance 0 Pain Relevance 0
However, these findings partially agreed with Wojcik and colleagues [3] who found that consumption of a carbohydrate and whole protein solution 6 hours following resistance exercise only had a trend (p < 0.08) to decrease plasma CK levels at early time points after exercise.
Negative_regulation (decrease) of CK in plasma
4) Confidence 0.39 Published 2008 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2288590 Disease Relevance 0.16 Pain Relevance 0.03
However, there was a non significant trend for CK levels to be lower in the group administered the milk and carbohydrate solution on the day of eccentric resistance exercise as compared to the placebo condition.
Negative_regulation (lower) of CK
5) Confidence 0.39 Published 2008 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2288590 Disease Relevance 0.25 Pain Relevance 0
Serum CK activity was measured in duplicate using an enzymatic assay kit (StanBio Laboratories; Borne, Texas) after all samples had been collected.
Negative_regulation (measured) of CK
6) Confidence 0.39 Published 2008 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2288590 Disease Relevance 0 Pain Relevance 0
Over 2 weeks, swelling of limbs was reduced and CK concentration was reduced to 931 IU/liter.
Negative_regulation (reduced) of CK in limbs associated with pressure and volume under development
7) Confidence 0.36 Published 1991 Journal Cent Afr J Med Section Abstract Doc Link 1806250 Disease Relevance 1.75 Pain Relevance 0.19
After starting treatment with steroids, his muscle weakness gradually ameliorated, CK level dramatically decreased, and the nodules disappeared.
Negative_regulation (decreased) of CK in nodules associated with muscle weakness
8) Confidence 0.36 Published 2008 Journal Rinsho Shinkeigaku Section Abstract Doc Link 18386630 Disease Relevance 1.38 Pain Relevance 0.26
RESULTS: While IP significantly reduced CK-MB (18.7 +/- 1.3 vs. 13.8 +/- 1.5 U/L, mean +/- SEM, p < 0.05), it only tended to reduce CK (292.7 +/- 32.8 vs. 274.1+/-31.1 U/L, p = NS, mean +/- SEM).
Negative_regulation (reduce) of CK
9) Confidence 0.36 Published 2005 Journal J Card Surg Section Body Doc Link 16153270 Disease Relevance 0 Pain Relevance 0
RESULTS: The patient improved clinically, CK level and SA steadily decreased.
Negative_regulation (decreased) of CK
10) Confidence 0.34 Published 2005 Journal Clin Neurophysiol Section Body Doc Link 16256429 Disease Relevance 0.15 Pain Relevance 0
Profound deficits in atrial bioenergetics were present with reduced activities of the phosphotransfer enzymes CK and AK, depletion of high-energy phosphates (ATP and creatine phosphate), and reduction of cellular energetic potential (ATP-to-ADP and creatine phosphate-to-Cr ratios).
Negative_regulation (reduced) of CK
11) Confidence 0.33 Published 2003 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 12626329 Disease Relevance 1.10 Pain Relevance 0.13
We observed a different dependency on contractile activity between total enzymatic activities of CK, LDH, and AChE, which were substantially reduced after paralysis, and GP and PGAM, which were unchanged.
Negative_regulation (reduced) of CK associated with paralysis
12) Confidence 0.33 Published 1990 Journal J. Neurochem. Section Abstract Doc Link 2152794 Disease Relevance 0.41 Pain Relevance 0.09
His serial cardiac marker assays revealed an elevated total creatine kinase (CK) and 2 negative cardiac troponin levels.
Negative_regulation (levels) of CK
13) Confidence 0.28 Published 2010 Journal CJEM Section Abstract Doc Link 20078923 Disease Relevance 0.36 Pain Relevance 0.16
This dual effect was found to depend on the activation / inactivation of Receptor Ck.
Negative_regulation (inactivation) of Ck
14) Confidence 0.21 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.30 Pain Relevance 0.07
The observation that the addition of 25OH-C to PBMCs cultured in medium enriched with 10% NHS is able to disrupt the Receptor Ck dependent down-regulation of hTERT, c-myc and PPAR?
Negative_regulation (regulation) of Ck
15) Confidence 0.21 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0 Pain Relevance 0
Two statin-intolerant patients had been hospitalized with rhabdomyolysis: each developed CK > 10,000 U/L within 6 weeks of statin monotherapy and myoglobinuria and transiently increased serum creatinine, but with eventual return to normal limits of renal function.
Negative_regulation (developed) of CK associated with myoglobinuria and rhabdomyolysis
16) Confidence 0.15 Published 2007 Journal Lipids Health Dis Section Body Doc Link PMC1832194 Disease Relevance 0.54 Pain Relevance 0
CK-MB activity assay were and are limited by their inability in detecting low concentrations of CK-MB.
Negative_regulation (limited) of CK-MB
17) Confidence 0.05 Published 2008 Journal Biomarker Insights Section Body Doc Link PMC2688349 Disease Relevance 0.50 Pain Relevance 0
Because H-FABP rapidly return to the normal range within 24 h after AMI, it can be also used to assess a recurrent infarction within 10 h after first AMI, possibly missed by CK-MB, cTnT and cTnI evaluation because plasma concentration of these markers returns more slowly to reference values.
Negative_regulation (evaluation) of CK-MB in plasma associated with infarction and myocardial infarction
18) Confidence 0.05 Published 2008 Journal Biomarker Insights Section Body Doc Link PMC2688349 Disease Relevance 0.70 Pain Relevance 0.05
As mentioned above, the cardiac enzyme profile indicated a loss of skeletal muscle, with serial measurements of CK and accessory MB-fraction showing peak levels of 2,600 and 29 U/l, respectively.
Negative_regulation (loss) of CK in skeletal muscle
19) Confidence 0.04 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2323010 Disease Relevance 1.54 Pain Relevance 0.18
Meanwhile, a second set of cardiac enzymes showed troponin I level of 515 ng/ml (Figure 1), CK-MB of 1120 ng/ml, and CK of 11623 ng/ml about six hours after his presentation to the ER.
Negative_regulation (level) of CK-MB
20) Confidence 0.02 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2881008 Disease Relevance 1.06 Pain Relevance 0.18

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