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Context Info
Confidence 0.56
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.12
Pain Relevance 1.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (OPRM1, OPRM1, GRIN1) Golgi apparatus (OPRM1, OPRM1) endoplasmic reticulum (OPRM1, OPRM1)
signal transducer activity (OPRM1, OPRM1)
OPRM1 (Homo sapiens)
OPRM1 (Homo sapiens)
GRIN1 (Homo sapiens)
Pain Link Frequency Relevance Heat
opioid receptor 8 100.00 Very High Very High Very High
Kinase C 3 98.00 Very High Very High Very High
agonist 1 92.80 High High
tolerance 7 88.12 High High
Morphine 5 87.72 High High
Glutamate receptor 1 82.80 Quite High
Opioid 6 76.48 Quite High
Physical dependence 1 55.16 Quite High
Disease Link Frequency Relevance Heat
Opiate Addiction 1 63.60 Quite High
Drug Dependence 1 55.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This process involves DOR regulation of MORs, MOR-induced activation of NMDARs (probably via the regulation of Src, recruiting PKC and Galpha subunits) and the NMDAR-mediated activation of CaMKII.
MOR Positive_regulation (induced) of MOR Positive_regulation (activation) of NMDAR associated with kinase c and opioid receptor
1) Confidence 0.56 Published 2008 Journal Curr Drug Abuse Rev Section Abstract Doc Link 19630721 Disease Relevance 0.12 Pain Relevance 1.45

General Comments

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