INT161863

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Context Info
Confidence 0.27
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.63
Pain Relevance 3.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Prkcg) plasma membrane (Prkcg) nucleus (Prkcg)
intracellular (Prkcg) response to stress (Prkcg) cytoplasm (Prkcg)
Prkcg (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 55 100.00 Very High Very High Very High
Inflammation 6 99.98 Very High Very High Very High
opioid receptor 8 99.82 Very High Very High Very High
dorsal root ganglion 53 99.60 Very High Very High Very High
bradykinin 2 96.16 Very High Very High Very High
gABA 2 95.68 Very High Very High Very High
agonist 8 92.32 High High
Morphine 5 90.88 High High
Inflammatory mediators 2 88.24 High High
tolerance 7 87.64 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 8 99.98 Very High Very High Very High
Ganglion Cysts 54 99.60 Very High Very High Very High
Nociception 5 99.28 Very High Very High Very High
Bone Cancer 43 75.20 Quite High
Opiate Addiction 1 63.12 Quite High
Pain 12 60.84 Quite High
Targeted Disruption 1 59.76 Quite High
Drug Dependence 3 54.68 Quite High
Hyperalgesia 5 49.76 Quite Low
Neuropathic Pain 16 48.76 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
and inflammation-induced up-regulation of PKC?
Positive_regulation (induced) of Regulation (regulation) of PKC associated with kinase c and inflammation
1) Confidence 0.27 Published 2010 Journal Mol Pain Section Body Doc Link PMC3004845 Disease Relevance 1.51 Pain Relevance 1.25
Importantly, we have also found that the pre-treatment with the PKC inhibitor Gö 6976 compromised the survival effects of BzATP, NMDA and specially that induced by BDNF, supporting the involvement of cPKC isoforms in the intracellular signalling triggered by these stimuli (Fig. 3b).
Positive_regulation (supporting) of Regulation (involvement) of cPKC
2) Confidence 0.20 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2858808 Disease Relevance 0 Pain Relevance 0.06
Alternatively, there is evidence that PKC- mediated functional regulation of DAT is not achieved by direct phosphorylation of the DAT protein [58], as has been demonstrated for the GABA transporter, where PKC down regulates transporter function by modulating the association of syntaxin with the transporter [59].
Positive_regulation (mediated) of Regulation (regulation) of PKC associated with gaba and kinase c
3) Confidence 0.08 Published 2009 Journal Mol Brain Section Body Doc Link PMC2687442 Disease Relevance 0 Pain Relevance 0.33
This process involves DOR regulation of MORs, MOR-induced activation of NMDARs (probably via the regulation of Src, recruiting PKC and Galpha subunits) and the NMDAR-mediated activation of CaMKII.
Positive_regulation (activation) of Regulation (regulation) of PKC associated with kinase c and opioid receptor
4) Confidence 0.03 Published 2008 Journal Curr Drug Abuse Rev Section Abstract Doc Link 19630721 Disease Relevance 0.12 Pain Relevance 1.46

General Comments

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