INT161877

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Context Info
Confidence 0.33
First Reported 2009
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.62
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Esrra) DNA binding (Esrra)
Anatomy Link Frequency
neuronal 1
neurons 1
Esrra (Mus musculus)
Pain Link Frequency Relevance Heat
Neuronal excitability 5 97.36 Very High Very High Very High
gABA 2 75.00 Quite High
depression 1 64.72 Quite High
Dismenorea 1 63.40 Quite High
hyperexcitability 1 46.16 Quite Low
Neuropeptide 5 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Neurotransmitter 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Anxiety Disorder 1 94.68 High High
Convulsion 1 93.20 High High
Stress 1 73.68 Quite High
Post-partum Depression 1 64.72 Quite High
Reprotox - General 1 1 63.40 Quite High
Epilepsy 1 62.48 Quite High
Neurological Disease 2 61.24 Quite High
Sleep Disorders 1 53.04 Quite High
Aids-related Complex 81 51.76 Quite High
Injury 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
More robust changes in steroid hormone levels, such as those that occur throughout pregnancy, result in a decrease in both GABAAR gamma2 and delta subunit expression and are associated with an increase in neuronal excitability evident from the shift in the input-output relationship.
Regulation (changes) of steroid hormone in neuronal associated with neuronal excitability
1) Confidence 0.33 Published 2009 Journal Psychoneuroendocrinology Section Abstract Doc Link 19632051 Disease Relevance 0.57 Pain Relevance 0.34
In order to better understand sex steroid hormone-dependent and -independent effects on the maturation of kisspeptin neurons, hypogonadal (hpg) mice deficient in GnRH and its downstream effectors were used to determine changes in the developmental kisspeptin expression.
Neg (independent) Regulation (effects) of steroid hormone in neurons
2) Confidence 0.03 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2912854 Disease Relevance 0.05 Pain Relevance 0

General Comments

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