INT161878

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Context Info
Confidence 0.57
First Reported 2007
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.75
Pain Relevance 0.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Gabrg2) plasma membrane (Gabrg2) cytoplasm (Gabrg2)
Anatomy Link Frequency
neuronal 2
cortex 2
Gabrg2 (Mus musculus)
Pain Link Frequency Relevance Heat
Neuronal excitability 5 98.40 Very High Very High Very High
Hippocampus 7 82.76 Quite High
gABA 11 75.00 Quite High
depression 1 60.96 Quite High
Dismenorea 1 59.64 Quite High
hyperexcitability 1 56.32 Quite High
anesthesia 1 50.00 Quite Low
Eae 5 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
GABAergic 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Anxiety Disorder 1 90.92 High High
Convulsion 3 89.44 High High
Sprains And Strains 2 72.60 Quite High
Stress 1 69.92 Quite High
Body Weight 19 67.92 Quite High
Sleep Disorders 1 63.20 Quite High
Post-partum Depression 1 60.96 Quite High
Targeted Disruption 60 60.80 Quite High
Reprotox - General 1 1 59.64 Quite High
Epilepsy 1 58.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
More robust changes in steroid hormone levels, such as those that occur throughout pregnancy, result in a decrease in both GABAAR gamma2 and delta subunit expression and are associated with an increase in neuronal excitability evident from the shift in the input-output relationship.
Negative_regulation (decrease) of Gene_expression (expression) of gamma2 in neuronal associated with neuronal excitability
1) Confidence 0.57 Published 2009 Journal Psychoneuroendocrinology Section Abstract Doc Link 19632051 Disease Relevance 0.55 Pain Relevance 0.36
Blots of cortex from forebrain selective knockouts and controls were also analyzed for GABAA-R ?
Negative_regulation (Blots) of Spec (analyzed) Gene_expression (analyzed) of GABAA-R in cortex
2) Confidence 0.19 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2100059 Disease Relevance 0.20 Pain Relevance 0.04

General Comments

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