INT161882

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Context Info
Confidence 0.41
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 6.54
Pain Relevance 0.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (NPHS1) plasma membrane (NPHS1) protein complex (NPHS1)
Anatomy Link Frequency
plasma 4
neuronal 2
diaphragm 2
podocytes 2
NPHS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 4 99.00 Very High Very High Very High
narcan 2 97.44 Very High Very High Very High
Inflammation 36 83.44 Quite High
Pain 12 82.24 Quite High
antinociception 1 79.48 Quite High
midbrain 1 70.40 Quite High
cytokine 20 70.24 Quite High
Inflammatory mediators 12 66.60 Quite High
Inflammatory response 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Burns 296 99.04 Very High Very High Very High
Acute Renal Failure 332 97.84 Very High Very High Very High
Sepsis 104 96.32 Very High Very High Very High
Proteinuria 132 96.20 Very High Very High Very High
Apoptosis 164 93.60 High High
Disorders Of Creatine Metabolism 28 93.12 High High
INFLAMMATION 52 83.44 Quite High
Pain 9 82.24 Quite High
Injury 60 81.44 Quite High
Renal Disease 20 79.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results showed that: 1) the majority of neurons in the CnF displayed monophasic excitatory responses in the first or second phase after formalin injection, except a small portion of neurons which did not exhibit any responses; 2) unit activity of CnF neurons was suppressed after subcutaneous (sc) morphine administration and resumed by naloxone; 3) the increased neuronal firing induced by sc formalin could be suppressed by a single dose of sc morphine; and 4) the response patterns of many CnF neurons changed by preinjection of morphine during 2 phases of the formalin test.
Negative_regulation (suppressed) of Gene_expression (neurons) of CnF in neuronal associated with narcan and morphine
1) Confidence 0.41 Published 2010 Journal J Pain Section Abstract Doc Link 19632161 Disease Relevance 0.22 Pain Relevance 0.68
We also observed a marked down-regulation of nephrin expression in cultured podocytes after exposure to burns septic ARF group plasma.
Negative_regulation (down) of Gene_expression (expression) of nephrin in plasma associated with acute renal failure and burns
2) Confidence 0.20 Published 2008 Journal Crit Care Section Body Doc Link PMC2447585 Disease Relevance 1.21 Pain Relevance 0.06
We also observed a marked down-regulation of nephrin expression in cultured podocytes after exposure to burns septic ARF group plasma.
Negative_regulation (regulation) of Gene_expression (expression) of nephrin in plasma associated with acute renal failure and burns
3) Confidence 0.20 Published 2008 Journal Crit Care Section Body Doc Link PMC2447585 Disease Relevance 1.21 Pain Relevance 0.06
In podocytes, plasma from septic burns patients increased permeability to albumin and decreased the expression of the slit diaphragm protein nephrin.


Negative_regulation (decreased) of Gene_expression (expression) of nephrin in diaphragm associated with burns
4) Confidence 0.18 Published 2008 Journal Crit Care Section Abstract Doc Link PMC2447585 Disease Relevance 2.32 Pain Relevance 0.04
In podocytes, burns septic group plasma increased permeability to albumin and decreased the expression of the slit diaphragm protein nephrin.


Negative_regulation (decreased) of Gene_expression (expression) of nephrin in podocytes associated with burns
5) Confidence 0.18 Published 2008 Journal Crit Care Section Body Doc Link PMC2447585 Disease Relevance 1.56 Pain Relevance 0.11

General Comments

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