INT161903

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Context Info
Confidence 0.43
First Reported 2008
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 1.90
Pain Relevance 1.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cxadr) extracellular region (Cxadr) cell adhesion (Cxadr)
mitochondrion organization (Cxadr) plasma membrane (Cxadr) nucleus (Cxadr)
Anatomy Link Frequency
CAR 4
neurons 1
Cxadr (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 3 100.00 Very High Very High Very High
dexamethasone 3 99.92 Very High Very High Very High
Substantia nigra 54 99.26 Very High Very High Very High
Dopamine 54 98.88 Very High Very High Very High
Central nervous system 27 88.88 High High
aspirin 1 80.48 Quite High
cINOD 1 78.60 Quite High
Inflammation 1 78.32 Quite High
Analgesic 1 77.00 Quite High
corticosteroid 1 74.92 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 219 99.96 Very High Very High Very High
Infection 16 94.64 High High
Rabies Virus Infection 3 91.64 High High
Arrhythmia Under Development 38 89.92 High High
Disease 17 88.56 High High
INFLAMMATION 1 78.32 Quite High
Parkinson's Disease 45 77.68 Quite High
Neurodegenerative Disease 9 76.52 Quite High
Cancer 11 56.84 Quite High
Cytomegalovirus Infection 9 45.68 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To determine which genes contribute to the development of the AV block phenotype, we have obtained preliminary expression profiling data from mouse atria that show the expected down-regulation of CAR (>10-fold down in the KO) and suggest a specific role of connexin 43.
Regulation (regulation) of CAR in CAR associated with targeted disruption
1) Confidence 0.43 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556793 Disease Relevance 0.34 Pain Relevance 0
Expression of connexins was differentially affected in the CAR KO heart.
Regulation (affected) of CAR in CAR associated with targeted disruption
2) Confidence 0.37 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556793 Disease Relevance 0.40 Pain Relevance 0
Our objective was to evaluate the role of CAR protein in transduction of dopamine (DA) neurons in vivo.


Regulation (role) of CAR in neurons associated with dopamine
3) Confidence 0.29 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2941453 Disease Relevance 0.44 Pain Relevance 0.30
The most promising alternative is the use of modified forms of Ad, which do not depend on CAR for their cellular tropism.
Neg (not) Regulation (depend) of CAR in CAR
4) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2941453 Disease Relevance 0.18 Pain Relevance 0.16
In wild type mice, however, our western blot studies suggest that the overall abundance of mCAR in the SN is quite low, and we were unable to detect the endogenous mCAR protein by immunohistochemistry in the SN.
Neg (unable) Regulation (detect) of mCAR associated with substantia nigra
5) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2941453 Disease Relevance 0.47 Pain Relevance 0.18
The low values of limits of detection (LOD) for PAR, SOT, MTZ, MET, SAL, PRO, PRE, CAR, DEX and KET were achieved: 106 ng L(-1), 1,048 ng L(-1), 2.48 ng L(-1), 2.17 ng L(-1), 16.5 ng L(-1), 1.10 ng L(-1), 160 ng L(-1), 6.62 ng L(-1), 76.5 ng L(-1) and 45.2 ng L(-1), respectively.
Regulation (values) of CAR in CAR associated with paracetamol and dexamethasone
6) Confidence 0.03 Published 2009 Journal Water Sci. Technol. Section Abstract Doc Link 19633387 Disease Relevance 0.08 Pain Relevance 0.69

General Comments

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