INT161942

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Context Info
Confidence 0.62
First Reported 2006
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 12
Total Number 14
Disease Relevance 4.84
Pain Relevance 2.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (F2RL1) plasma membrane (F2RL1) signal transducer activity (F2RL1)
Anatomy Link Frequency
teeth 4
endothelial cells 2
cartilage 2
tooth pulp 2
F2RL1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 396 99.68 Very High Very High Very High
agonist 114 99.42 Very High Very High Very High
Pain 14 97.96 Very High Very High Very High
cytokine 81 90.16 High High
Inflammation 207 88.16 High High
metalloproteinase 148 83.12 Quite High
chemokine 21 71.28 Quite High
Inflammatory mediators 18 52.40 Quite High
Bioavailability 6 47.24 Quite Low
Arthritis 27 37.28 Quite Low
Disease Link Frequency Relevance Heat
Cancer 90 99.76 Very High Very High Very High
Osteoarthritis 402 99.68 Very High Very High Very High
Pain 14 97.96 Very High Very High Very High
Toxicity 82 93.60 High High
INFLAMMATION 222 88.16 High High
Necrosis 20 85.76 High High
Death 54 83.16 Quite High
Apoptosis 42 82.76 Quite High
Hyperplasia 3 69.00 Quite High
Viral Meningitis 4 58.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Changes in proteinase-activated receptor 2 expression in the human tooth pulp in relation to caries and pain.
Regulation (Changes) of Gene_expression (expression) of proteinase-activated receptor 2 in tooth pulp associated with pain
1) Confidence 0.62 Published 2009 Journal J Orofac Pain Section Title Doc Link 19639106 Disease Relevance 0.10 Pain Relevance 0.19
No changes in vascular PAR2 expression were found (P > .05); however, the number of PAR2-labeled fibroblast-like cells per mm2 was significantly greater in carious teeth (P < .05).
Neg (No) Regulation (changes) of Gene_expression (expression) of PAR2 in teeth
2) Confidence 0.62 Published 2009 Journal J Orofac Pain Section Body Doc Link 19639106 Disease Relevance 0.06 Pain Relevance 0
PAR2 neuronal expression was not affected by the presence of caries (P > .05) but was significantly less in carious painful teeth than in carious asymptomatic teeth (P < .05).
Neg (not) Regulation (affected) of Gene_expression (expression) of PAR2 in teeth
3) Confidence 0.62 Published 2009 Journal J Orofac Pain Section Body Doc Link 19639106 Disease Relevance 0.06 Pain Relevance 0
In this study, we also addressed the roles of candidate signalling events able to regulate PAR-2 production and, on the other hand, those responsible for the PAR-2-mediated functional response.
Regulation (regulate) of Gene_expression (production) of PAR-2
4) Confidence 0.60 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246240 Disease Relevance 0.26 Pain Relevance 0.24
Our finding that the PAR-2-AP, in addition to activating PAR-2, significantly upregulates the level of the receptor on OA chondrocytes agrees with a recent study showing that another PAR-2-AP agonist, 2-furoyl LIGKV-OH (ASK95), regulates the expression of PAR-2 in umbilical vein endothelial cells [18].
Regulation (regulates) of Gene_expression (expression) of PAR-2 in endothelial cells associated with agonist and osteoarthritis
5) Confidence 0.44 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246240 Disease Relevance 0.33 Pain Relevance 0.28
B inhibitions had no effect on PAR-2 synthesis.


Neg (no) Regulation (effect) of Gene_expression (synthesis) of PAR-2
6) Confidence 0.44 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246240 Disease Relevance 0.82 Pain Relevance 0.56
To explore the signalling pathways involved in the regulation of PAR-2 synthesis, human OA cartilage explants were incubated for 48 hours with the MAP kinase inhibitor SB 202190, inhibitor of p38; PD 98059, inhibitor of MEK1/2; and SN50, inhibitor of NF-?
Regulation (regulation) of Gene_expression (synthesis) of PAR-2 in cartilage associated with osteoarthritis
7) Confidence 0.44 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246240 Disease Relevance 0.76 Pain Relevance 0.47
B, as regulators of PAR-2 synthesis.
Regulation (regulators) of Gene_expression (synthesis) of PAR-2
8) Confidence 0.44 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246240 Disease Relevance 0.18 Pain Relevance 0.21
Similarly, factor D which is crucial for forming the C3 convertase that is pivotal for complement activation by classical, lectin and alternative pathways, was also slightly down-regulated (0.8 fold of control) by PAR2 activation.
Regulation (regulated) of Gene_expression (activation) of PAR2
9) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2970545 Disease Relevance 0.27 Pain Relevance 0.14
Key genes regulated by PAR2 activation
Regulation (regulated) of Gene_expression (activation) of PAR2
10) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2970545 Disease Relevance 0 Pain Relevance 0.11
Among other key players in cell cycle progression that were affected by PAR2 activation were tumor suppressor p53, cell division cycle members CDC123, CDC20 and CDC25A, and cell cycle regulators such as PPP2CA and PPP2CB.
Regulation (affected) of Gene_expression (activation) of PAR2 associated with cancer
11) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2970545 Disease Relevance 0.24 Pain Relevance 0.04
Regulation of PAR-2 synthesis
Regulation (Regulation) of Gene_expression (synthesis) of PAR-2
12) Confidence 0.26 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246240 Disease Relevance 0.52 Pain Relevance 0.35
In addition to increased prostaglandin formation, TNF-alpha increases the expression of proteinase-activated receptor-2 (PAR-2) which is responsible for cell survival [34].
Regulation (responsible) of Gene_expression (expression) of PAR-2
13) Confidence 0.07 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1510947 Disease Relevance 0.62 Pain Relevance 0.08
In addition to increased prostaglandin formation, TNF-alpha increases the expression of proteinase-activated receptor-2 (PAR-2) which is responsible for cell survival [34].
Regulation (responsible) of Gene_expression (expression) of proteinase-activated receptor-2
14) Confidence 0.05 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1510947 Disease Relevance 0.62 Pain Relevance 0.08

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