INT161968

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Context Info
Confidence 0.40
First Reported 2009
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.91
Pain Relevance 1.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (GAD2) lyase activity (GAD2) Golgi apparatus (GAD2)
cytoplasmic membrane-bounded vesicle (GAD2) plasma membrane (GAD2) cytoplasm (GAD2)
Anatomy Link Frequency
spinal cord 2
GAD2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Spinal cord 2 99.98 Very High Very High Very High
Pain 2 99.76 Very High Very High Very High
gABA 38 99.32 Very High Very High Very High
Sciatic nerve 5 96.80 Very High Very High Very High
GABAergic 69 93.68 High High
Potency 1 90.60 High High
Neuropathic pain 2 86.92 High High
peripheral neuropathy 1 74.00 Quite High
neuralgia 2 25.00 Low Low
Cannabinoid receptor 14 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pain 2 99.76 Very High Very High Very High
Aging 17 97.64 Very High Very High Very High
Lifespan 27 88.84 High High
Neuropathic Pain 2 86.92 High High
Nervous System Injury 1 79.24 Quite High
Peripheral Neuropathy 1 74.00 Quite High
Amblyopia 7 5.00 Very Low Very Low Very Low
Cataract 1 5.00 Very Low Very Low Very Low
Anxiety Disorder 1 5.00 Very Low Very Low Very Low
Cognitive Disorder 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For example, the peak of GAD65 expression was not reached until the teen to young adult years before falling off in aging.
Neg (not) Positive_regulation (reached) of Gene_expression (expression) of GAD65 associated with aging
1) Confidence 0.40 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2893712 Disease Relevance 0.40 Pain Relevance 0.21
Equally importantly, the GABA concentration in the spinal cord increased significantly after GAD65 introduction, and pain symptoms were dramatically reduced and persistently controlled.
Positive_regulation (increased) of Gene_expression (introduction) of GAD65 in spinal cord associated with pain, gaba and spinal cord
2) Confidence 0.15 Published 2009 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 19643087 Disease Relevance 0.51 Pain Relevance 0.83

General Comments

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