INT162

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Context Info
Confidence 0.62
First Reported 1974
Last Reported 2010
Negated 178
Speculated 73
Reported most in Abstract
Documents 794
Total Number 867
Disease Relevance 165.01
Pain Relevance 322.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Prl)
Anatomy Link Frequency
plasma 146
pituitary 28
follicle 16
blood 14
thyroid 13
Prl (Rattus norvegicus)
Pain Link Frequency Relevance Heat
narcan 1675 100.00 Very High Very High Very High
Morphine 744 100.00 Very High Very High Very High
antagonist 617 100.00 Very High Very High Very High
Dopamine 521 100.00 Very High Very High Very High
Opioid 456 100.00 Very High Very High Very High
opiate 417 100.00 Very High Very High Very High
agonist 396 100.00 Very High Very High Very High
anesthesia 251 100.00 Very High Very High Very High
Endogenous opioid 216 100.00 Very High Very High Very High
Serotonin 191 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 769 100.00 Very High Very High Very High
Galactorrhea 284 100.00 Very High Very High Very High
Cancer 230 100.00 Very High Very High Very High
Reprotox - General 1 185 100.00 Very High Very High Very High
Pain 111 100.00 Very High Very High Very High
Headache 109 100.00 Very High Very High Very High
Hypoglycemia 50 100.00 Very High Very High Very High
Sleep Disorders 38 100.00 Very High Very High Very High
Injury 27 100.00 Very High Very High Very High
Pressure And Volume Under Development 22 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effects of chronic hyperprolactinemia on plasma prolactin (PRL) and glucose were investigated in male rats submitted to two different types of stress: restraint (60 min in a plastic tube) or surgery (laparotomy under ether anesthesia).
Regulation (effects) of PRL in tube associated with stress, galactorrhea and anesthesia
1) Confidence 0.62 Published 1996 Journal Life Sci. Section Abstract Doc Link 8606624 Disease Relevance 0.49 Pain Relevance 0.09
The effects of hyperprolactinemia on plasma prolactin (PRL) and glucose were investigated in female rats submitted to surgical stress (laparotomy under ether anesthesia).
Regulation (effects) of PRL in plasma associated with stress, galactorrhea and anesthesia
2) Confidence 0.62 Published 1996 Journal Braz. J. Med. Biol. Res. Section Abstract Doc Link 9070395 Disease Relevance 0.39 Pain Relevance 0.10
Somatic afferent regulation of plasma prolactin in anesthetized rats.
Regulation (regulation) of prolactin in plasma associated with anesthesia
3) Confidence 0.62 Published 1993 Journal Jpn. J. Physiol. Section Title Doc Link 8114360 Disease Relevance 0.06 Pain Relevance 0.45
Since these PRL surges may be regulated in part by endogenous opioids and opioid sensitivity declines as a function of multiple births, we decided to investigate the possibility that prior parity might affect the post-coital diurnal and nocturnal PRL surges, reducing their magnitude and/or occurrence.
Regulation (regulated) of PRL associated with endogenous opioid and opioid
4) Confidence 0.62 Published 1993 Journal Life Sci. Section Abstract Doc Link 8336523 Disease Relevance 0 Pain Relevance 0.20
The PRL levels of the grafted rats were increased 3.5-fold compared to the sham-operated controls before stress (20.2 +/- 5.6 ng/ml vs 5.8 +/- 0.9 ng/ml, respectively; P < 0.05), but did not change significantly during the experimental period.
Neg (not) Regulation (change) of PRL associated with stress
5) Confidence 0.62 Published 1996 Journal Braz. J. Med. Biol. Res. Section Abstract Doc Link 9070395 Disease Relevance 0.57 Pain Relevance 0.08
In normal male rats, the intraventricular injection of 0.25 micrograms/kg of dermorphin is not able to induce any significant changes in serum Prl levels 10 min after injection.
Regulation (changes) of Prl
6) Confidence 0.62 Published 1984 Journal Neuroendocrinology Section Abstract Doc Link 6504268 Disease Relevance 0.08 Pain Relevance 0.32
The effects of chronic hyperprolactinemia on plasma prolactin (PRL) and glucose were investigated in male rats submitted to two different types of stress: restraint (60 min in a plastic tube) or surgery (laparotomy under ether anesthesia).
Regulation (effects) of prolactin in tube associated with stress, galactorrhea and anesthesia
7) Confidence 0.62 Published 1996 Journal Life Sci. Section Abstract Doc Link 8606624 Disease Relevance 0.49 Pain Relevance 0.09
Measurement of plasma PRL by radioimmunoassay revealed that prior reproductive experience altered the patterns and levels of plasma PRL.
Regulation (altered) of PRL in plasma
8) Confidence 0.62 Published 1993 Journal Life Sci. Section Abstract Doc Link 8336523 Disease Relevance 0 Pain Relevance 0.15
Effects of morphine on the serum prolactin levels of morphine-tolerant and nontolerant male rats and of the in vitro release of pituitary prolactin.
Regulation (Effects) of prolactin in pituitary associated with narcan and morphine
9) Confidence 0.62 Published 1978 Journal Jpn. J. Pharmacol. Section Title Doc Link 745306 Disease Relevance 0 Pain Relevance 1.19
In previous studies we provided evidence for changes in prolactin (PRL) receptor levels in the male rat brain after continuously infusing morphine using subcutaneously implanted miniosmotic pumps.
Regulation (changes) of prolactin in brain associated with morphine
10) Confidence 0.62 Published 1995 Journal Neurosci. Res. Section Abstract Doc Link 8545080 Disease Relevance 0 Pain Relevance 0.29
In previous studies we provided evidence for changes in prolactin (PRL) receptor levels in the male rat brain after continuously infusing morphine using subcutaneously implanted miniosmotic pumps.
Regulation (changes) of PRL in brain associated with morphine
11) Confidence 0.62 Published 1995 Journal Neurosci. Res. Section Abstract Doc Link 8545080 Disease Relevance 0 Pain Relevance 0.30
Atropine (a muscarinic chilinergic blocker), arecoline (a muscarinic stimulator) and nicotine (a nicotinic cholinergic stimulating drug) did not affect basal prolactin levels.
Neg (not) Regulation (affect) of prolactin associated with nicotine
12) Confidence 0.62 Published 1975 Journal Endocrinology Section Abstract Doc Link 234380 Disease Relevance 0 Pain Relevance 0.26
The influence of adrenergic, dopaminergic, cholinergic and serotoninergic drugs on plasma prolactin levels in ovariectomized, estrogen-treated rats.
Regulation (influence) of prolactin in plasma
13) Confidence 0.62 Published 1975 Journal Endocrinology Section Title Doc Link 234380 Disease Relevance 0 Pain Relevance 0.20
Depletion of serotonin stores by pretreatment with p-chloro-phenylalanine methyl-ester (PCPA; 3 x 300 mg/kg ip) significantly prevent the effect of quipazine on prolactin levels.
Regulation (effect) of prolactin associated with serotonin
14) Confidence 0.62 Published 1988 Journal Pol J Pharmacol Pharm Section Abstract Doc Link 2467272 Disease Relevance 0 Pain Relevance 0.48
Absence of an effect of dietary corn oil content on plasma prolactin, progesterone, and 17 beta-estradiol in female Sprague-Dawley rats.
Regulation (effect) of prolactin in plasma
15) Confidence 0.62 Published 1984 Journal Cancer Res. Section Title Doc Link 6423274 Disease Relevance 0 Pain Relevance 0
We explored the role of the opioid system and the participation of ovarian hormones in the regulation of prolactin induced by the suckling stimulus at the end of pregnancy in rats with developed maternal behavior, and during lactation.
Regulation (regulation) of prolactin associated with opioid
16) Confidence 0.62 Published 2002 Journal J. Endocrinol. Section Abstract Doc Link 11834443 Disease Relevance 0 Pain Relevance 0.37
Ipsapirone administration for 21 days reduced fluid intake and decreased body weight, but did not affect baseline plasma glucose, corticosterone, and prolactin levels or cortical 5-HT2 receptor number.
Neg (not) Regulation (affect) of prolactin in plasma associated with body weight
17) Confidence 0.62 Published 1993 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8095465 Disease Relevance 0.35 Pain Relevance 0.39
No effect of dietary corn oil content or of DMBA administration on plasma prolactin and progesterone was detected in either age group.
Neg (No) Regulation (effect) of prolactin in plasma
18) Confidence 0.62 Published 1984 Journal Cancer Res. Section Abstract Doc Link 6423274 Disease Relevance 0 Pain Relevance 0
Taken together, these results clearly suggest that the central effects of PRL on ME are modulated by adrenergic mechanisms.
Regulation (modulated) of PRL
19) Confidence 0.62 Published 2001 Journal Physiol. Behav. Section Abstract Doc Link 11564459 Disease Relevance 0 Pain Relevance 0.08
There was a 34% inhibition of the effect of fenfluramine on plasma prolactin levels, but this effect was not statistically significant.
Regulation (effect) of prolactin in plasma
20) Confidence 0.62 Published 1985 Journal Neuroendocrinology Section Abstract Doc Link 2931613 Disease Relevance 0 Pain Relevance 0.49

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