INT162010

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Context Info
Confidence 0.81
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.47
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Sod2) oxidoreductase activity (Sod2) aging (Sod2)
mitochondrion organization (Sod2) DNA binding (Sod2) response to stress (Sod2)
Anatomy Link Frequency
smooth muscle 1
Sod2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 10 89.48 High High
Paracetamol 3 75.00 Quite High
Bioavailability 4 69.40 Quite High
Kinase C 1 6.20 Low Low
Inflammation 2 5.00 Very Low Very Low Very Low
Potency 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 5 92.08 High High
Hepatotoxicity 3 89.64 High High
Infection 2 77.44 Quite High
Increased Venous Pressure Under Development 6 72.84 Quite High
Obesity 9 44.32 Quite Low
Hyperinsulinism 3 27.44 Quite Low
Disease 4 5.00 Very Low Very Low Very Low
Insulin Resistance 3 5.00 Very Low Very Low Very Low
Body Weight 3 5.00 Very Low Very Low Very Low
Diabetes Mellitus 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mitochondria are the major source of superoxide production, and SOD2 is mainly localized in mitochondria and, with other SODs, plays an important role in scavenging superoxide.
Localization (localized) of SOD2
1) Confidence 0.81 Published 2009 Journal Toxicology Section Abstract Doc Link 19647030 Disease Relevance 0.40 Pain Relevance 0.13
At least three isoforms of SOD exist in mammalian tissues, namely Cu/Zn SOD (SOD1), MnSOD (SOD2) and extracellular SOD (EcSOD or SOD3) that are located in cytosol, mitochondria and vascular smooth muscle, respectively [40,41].
Localization (located) of SOD2 in smooth muscle
2) Confidence 0.41 Published 2008 Journal BMC Physiol Section Body Doc Link PMC2443377 Disease Relevance 0.07 Pain Relevance 0.12

General Comments

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