INT16202

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Context Info
Confidence 0.58
First Reported 1991
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 8
Total Number 11
Disease Relevance 5.24
Pain Relevance 1.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Shbg) extracellular region (Shbg)
Anatomy Link Frequency
follicle 4
fat 2
Shbg (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 6 99.84 Very High Very High Very High
withdrawal 6 99.48 Very High Very High Very High
Pain 15 98.32 Very High Very High Very High
narcan 1 89.88 High High
Migraine 1 89.52 High High
Onset of action 1 87.36 High High
agonist 6 86.20 High High
antagonist 7 85.52 High High
cva 21 58.80 Quite High
headache 8 56.24 Quite High
Disease Link Frequency Relevance Heat
Aging 3 98.84 Very High Very High Very High
Pain 14 98.32 Very High Very High Very High
Hypercalcemia 3 97.28 Very High Very High Very High
Hirsutism 62 96.12 Very High Very High Very High
Syndrome 10 93.36 High High
Metastasis 9 92.60 High High
Breast Cancer 162 90.04 High High
Hypertension 3 89.76 High High
Hyperandrogenism 4 89.72 High High
Headache 9 89.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The pretreatment of NG-monomethyl-L-arginine dose-dependently reduced the elevation of ABP but did not completely abolish it.
Negative_regulation (reduced) of Positive_regulation (elevation) of ABP
1) Confidence 0.58 Published 1995 Journal Artif Organs Section Abstract Doc Link 7763190 Disease Relevance 0 Pain Relevance 0
Pretreatment with various blockers did not abolish the elevation of ABP.
Neg (not) Negative_regulation (abolish) of Positive_regulation (elevation) of ABP
2) Confidence 0.58 Published 1995 Journal Artif Organs Section Abstract Doc Link 7763190 Disease Relevance 0 Pain Relevance 0
Administration of both drugs produced a significant suppression of elevation of SBP, and produced a significant elevation of pain sensitivity.
Negative_regulation (suppression) of Positive_regulation (elevation) of SBP associated with pain
3) Confidence 0.56 Published 1991 Journal Nippon Jinzo Gakkai Shi Section Abstract Doc Link 1808360 Disease Relevance 1.02 Pain Relevance 0.75
Moreover, regitine was shown to inhibit the increase of mABP in morphine withdrawal rats, but can not inhibit the increase of HR.
Negative_regulation (inhibit) of Positive_regulation (increase) of mABP associated with withdrawal and morphine
4) Confidence 0.43 Published 1998 Journal Yao Xue Xue Bao Section Abstract Doc Link 12016923 Disease Relevance 0.27 Pain Relevance 0.74
Levels of sex hormone binding globulin (SHBG), a protein increased by EE to which NET binds, were also examined.
Spec (examined) Negative_regulation (Levels) of Positive_regulation (increased) of SHBG
5) Confidence 0.41 Published 2000 Journal J Clin Pharmacol Section Abstract Doc Link 10709161 Disease Relevance 0.09 Pain Relevance 0.18
In both phase I and II studies arzoxifene showed similar endocrine effects of decreasing FSH and LH levels with increasing SHBG levels as had been reported with tamoxifen (L√łnning et al. 1995; Kostoglou-Athanassiou et al. 1997).
Negative_regulation (decreasing) of Positive_regulation (increasing) of SHBG
6) Confidence 0.32 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012444 Disease Relevance 0.56 Pain Relevance 0.08
There was a significant decrease in follicle-stimulating hormone (FSH) and luteinizing hormone (LH) levels, along with an increase in sex hormone-binding globulin (SHBG).
Negative_regulation (decrease) of Positive_regulation (increase) of SHBG in follicle
7) Confidence 0.32 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012444 Disease Relevance 0.78 Pain Relevance 0.06
There was a significant decrease in follicle-stimulating hormone (FSH) and luteinizing hormone (LH) levels, along with an increase in sex hormone-binding globulin (SHBG).
Negative_regulation (decrease) of Positive_regulation (increase) of hormone-binding globulin in follicle
8) Confidence 0.28 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012444 Disease Relevance 0.78 Pain Relevance 0.06
In an earlier study Tymchuk et al. (28) had reported that men attending the Pritikin Longevity Center low-fat diet and exercise program had significant reductions in serum insulin and significant elevations in sex hormone-binding globulin.
Negative_regulation (reductions) of Positive_regulation (elevations) of hormone-binding globulin in fat associated with aging
9) Confidence 0.18 Published 2004 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC538507 Disease Relevance 0.31 Pain Relevance 0
reducing gonadotropin secretion and thereby reducing ovarian androgen production.[18]increasing levels of SHBG resulting in lower levels of free testosterone.inhibiting adrenal androgen production.[19]

Androgen receptor blockers

Negative_regulation (reducing) of Positive_regulation (increasing) of SHBG
10) Confidence 0.09 Published 2010 Journal Indian Journal of Dermatology Section Body Doc Link PMC2856356 Disease Relevance 0.73 Pain Relevance 0
reducing gonadotropin secretion and thereby reducing ovarian androgen production.[18]increasing levels of SHBG resulting in lower levels of free testosterone.inhibiting adrenal androgen production.[19]

Androgen receptor blockers

Negative_regulation (reducing) of Positive_regulation (increasing) of SHBG
11) Confidence 0.09 Published 2010 Journal Indian Journal of Dermatology Section Body Doc Link PMC2856356 Disease Relevance 0.71 Pain Relevance 0

General Comments

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