INT162048

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Context Info
Confidence 0.43
First Reported 2005
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 3.30
Pain Relevance 0.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (OSM) extracellular space (OSM) extracellular region (OSM)
Anatomy Link Frequency
macrophages 2
OSM (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 122 100.00 Very High Very High Very High
cytokine 10 99.80 Very High Very High Very High
Inflammation 21 94.88 High High
Angina 2 92.16 High High
Central nervous system 2 5.00 Very Low Very Low Very Low
Glutamate 2 5.00 Very Low Very Low Very Low
Osteoarthritis 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
methotrexate 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 122 100.00 Very High Very High Very High
Leukemia 1 99.80 Very High Very High Very High
Increased Venous Pressure Under Development 13 98.00 Very High Very High Very High
INFLAMMATION 18 94.88 High High
Myocardial Infarction 4 94.12 High High
Cv General 3 Under Development 2 92.16 High High
Stroke 4 91.48 High High
Disease 21 85.84 High High
Cancer 20 70.56 Quite High
Death 1 56.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We show that the coagulation enzyme thrombin up-regulates oncostatin M (OSM), a pleiotropic cytokine implicated in the pathophysiology of vascular disease, in human monocyte-derived macrophages (MDMs) up to 16.8-fold.
Regulation (regulates) of OSM in macrophages associated with increased venous pressure under development and cytokine
1) Confidence 0.43 Published 2009 Journal Blood Section Abstract Doc Link 19652200 Disease Relevance 1.16 Pain Relevance 0.31
We show that the coagulation enzyme thrombin up-regulates oncostatin M (OSM), a pleiotropic cytokine implicated in the pathophysiology of vascular disease, in human monocyte-derived macrophages (MDMs) up to 16.8-fold.
Regulation (regulates) of oncostatin M in macrophages associated with increased venous pressure under development and cytokine
2) Confidence 0.43 Published 2009 Journal Blood Section Abstract Doc Link 19652200 Disease Relevance 1.16 Pain Relevance 0.31
We therefore speculate that PDCD10-OSM and PDCD10-VEGFR2 interactions may be regulated by the availability of PtdIns(3,4,5)P3 generated by PI3K.
Spec (may) Regulation (regulated) of OSM
3) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909203 Disease Relevance 0 Pain Relevance 0
Several of the cytokines that are abundant in RA, such as IL-6, oncostatin M and leukaemia inhibitory factor, suppress thymic function [37].
Regulation (abundant) of oncostatin M associated with leukemia, rheumatoid arthritis and cytokine
4) Confidence 0.04 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064881 Disease Relevance 0.98 Pain Relevance 0.32

General Comments

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