INT16205

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Context Info
Confidence 0.73
First Reported 1991
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 25
Total Number 28
Disease Relevance 18.99
Pain Relevance 1.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
kidney 2
Lung 2
smooth muscle 1
aorta 1
MCF-7 1
ras (Mus musculus)
Pain Link Frequency Relevance Heat
analgesia 5 100.00 Very High Very High Very High
Chronic pancreatitis 4 100.00 Very High Very High Very High
Pain 7 98.08 Very High Very High Very High
Calcium channel 17 97.66 Very High Very High Very High
Catecholamine 3 92.60 High High
Inflammation 75 91.60 High High
Neurotransmitter 4 91.60 High High
headache 6 90.44 High High
Central nervous system 1 89.88 High High
Dopamine 1 80.28 Quite High
Disease Link Frequency Relevance Heat
Hemangiosarcoma 278 100.00 Very High Very High Very High
Canker Sores 80 100.00 Very High Very High Very High
Stress 17 100.00 Very High Very High Very High
Renal Artery Obstruction 11 100.00 Very High Very High Very High
Pancreatitis 6 100.00 Very High Very High Very High
Tinnitus 192 99.84 Very High Very High Very High
Disease 31 98.92 Very High Very High Very High
Nicotine Addiction 78 98.68 Very High Very High Very High
Injury 7 98.28 Very High Very High Very High
Cancer 639 97.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
When both these two factors; intensity and duration of cigarette smoking, were combined, even moderate cigarette smokers for periods more than five years and heavy cigarette smokers for periods less than five years had significantly lower risk of getting RAS (?
Localization (getting) of RAS associated with nicotine addiction and canker sores
1) Confidence 0.73 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2999509 Disease Relevance 1.86 Pain Relevance 0
Although the etiology of RAS is not well understood, a number of factors may play a role, including nutritional deficiencies.
Localization (etiology) of RAS associated with nutritional deficiencies and canker sores
2) Confidence 0.71 Published 2010 Journal J. Oral Pathol. Med. Section Abstract Doc Link 20141576 Disease Relevance 0.66 Pain Relevance 0.10
Thus, from a physiologic perspective, aliskiren seems a promising drug which shows effective blockade of the RAS (Nussberger et al 2002).
Localization (blockade) of RAS
3) Confidence 0.63 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350139 Disease Relevance 0.24 Pain Relevance 0
Lesions of RAS localize clinically and experimentally at sites of trauma.
Localization (localize) of RAS associated with injury and canker sores
4) Confidence 0.58 Published 1991 Journal Med. Hypotheses Section Abstract Doc Link 1809853 Disease Relevance 0.93 Pain Relevance 0.19
The frequence of ras mutations in chronic pancreatitis, either in pancreatic tissue or pancreatic secretions, vary between 0 and 100%.
Localization (secretions) of ras associated with chronic pancreatitis
5) Confidence 0.55 Published 2000 Journal Int. J. Pancreatol. Section Abstract Doc Link 10862508 Disease Relevance 0.77 Pain Relevance 0.20
A better understanding of perioperative pharmacology and physiology of RAS blockade is needed as well as future studies to identify causality.


Localization (blockade) of RAS
6) Confidence 0.53 Published 2010 Journal Can J Anaesth Section Body Doc Link 20524103 Disease Relevance 0 Pain Relevance 0
These intermediates are needed for post-translational prenylation of small GTP-binding proteins (Ras, Rac and Rho) which are essential for many cellular functions such as proliferation, survival and invasiveness.
Localization (prenylation) of Ras
7) Confidence 0.35 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2294135 Disease Relevance 0.33 Pain Relevance 0.03
Although the precise mode of action of aminobisphosphonates is not understood, the mechanisms that have been recognized are based on their ability to impair post-translational prenylation of Ras, Rac and Rho [12,58].
Localization (prenylation) of Ras
8) Confidence 0.35 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2294135 Disease Relevance 0.28 Pain Relevance 0.04
Control animals showed a robust attenuation of both the pASR and the gASR regardless of the frequency that was tested (Figure 3).
Localization (attenuation) of pASR
9) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3002264 Disease Relevance 0.11 Pain Relevance 0.03
ASR characterization of tinnitus percepts
Localization (characterization) of ASR associated with tinnitus
10) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3002264 Disease Relevance 0.69 Pain Relevance 0.04
Data on PPIs, H(2)RAs, NSAIDs, and cyclooxygenase (COX)-2 inhibitors dispensed between 1997 and 2006 were gathered from Medicare Australia and are expressed as defined daily doses (DDDs) per 1000 concession beneficiaries per day (CBPDs).
Localization (cyclooxygenase) of RAs
11) Confidence 0.27 Published 2009 Journal Clin Ther Section Body Doc Link 19446158 Disease Relevance 0 Pain Relevance 0
Messenger RNAs (mRNA) for all the components of RAS were also quantified with the reverse transcriptase-polymerase chain reaction (RT-PCR) and localized by in situ hybridization in myocardial biopsy specimens from patients who underwent aorta-coronary bypass surgery.
Localization (localized) of RAS in aorta
12) Confidence 0.21 Published 2001 Journal J. Am. Coll. Cardiol. Section Body Doc Link 11451295 Disease Relevance 0.08 Pain Relevance 0
Brain renin angiotensin system (RAS) in stress-induced analgesia and impaired retention.
Localization (retention) of RAS in Brain associated with stress and analgesia
13) Confidence 0.20 Published 1999 Journal Peptides Section Title Doc Link 10447091 Disease Relevance 0.65 Pain Relevance 0.48
Lung and kidney tissues were collected to ensure that these organs, both of which are important in the systemic RAS and which have important local RAS, were unaltered by treatment (Figure 7).
Localization (important) of RAS in kidney
14) Confidence 0.18 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2902462 Disease Relevance 1.02 Pain Relevance 0
Lung and kidney tissues were collected to ensure that these organs, both of which are important in the systemic RAS and which have important local RAS, were unaltered by treatment (Figure 7).
Localization (important) of RAS in kidney
15) Confidence 0.16 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2902462 Disease Relevance 1.02 Pain Relevance 0
While the US-American JNC-7 recommendation from 2003 asks for a diuretic to be “usually” contained in a 2-drug combination strategy, the European guideline recommends various combinations both with and without a diuretic.2,12 More specifically, the recently revised European (ESC/ESH) guidelines recommend the following options for 2-drug combinations: diuretic plus either calcium channel blocker (CCB) or renin–angiotensin system (RAS) blocker (ACE inhibitor or angiotensin receptor blocker) or CCB plus RAS blocker.14 An additional discrepancy between US-American and European guidelines concerns the use of ?
Localization (blocker.14) of RAS associated with calcium channel
16) Confidence 0.15 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2879293 Disease Relevance 0.05 Pain Relevance 0.12
Our own studies have shown that treatment of both MCF-7 and MDA-MB-231 cells with zoledronic acid leads to impaired membrane localization of Ras that is consistent with impaired farnesylation [27].
Localization (localization) of Ras in MDA-MB-231
17) Confidence 0.10 Published 2002 Journal Breast Cancer Res Section Body Doc Link PMC138711 Disease Relevance 0.74 Pain Relevance 0
With renal artery stenosis (RAS), renin secretion is increased resulting in high circulating angiotensin II (A-II) levels, leading to HTN and hyperaldosteronism resulting in pressure natriuresis [5].
Localization (secretion) of RAS in renal artery associated with natriuresis, renal artery obstruction, pressure and volume under development and hyperaldosteronism
18) Confidence 0.08 Published 2004 Journal BMC Nephrol Section Body Doc Link PMC420241 Disease Relevance 2.35 Pain Relevance 0.14
Lung and kidney tissues were collected to ensure that these organs, both of which are important in the systemic RAS and which have important local RAS, were unaltered by treatment (Figure 7).
Localization (important) of RAS in Lung
19) Confidence 0.06 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2902462 Disease Relevance 1.02 Pain Relevance 0
Lung and kidney tissues were collected to ensure that these organs, both of which are important in the systemic RAS and which have important local RAS, were unaltered by treatment (Figure 7).
Localization (important) of RAS in Lung
20) Confidence 0.05 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2902462 Disease Relevance 1.02 Pain Relevance 0

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