INT162064

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Context Info
Confidence 0.63
First Reported 2007
Last Reported 2010
Negated 4
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 2.71
Pain Relevance 1.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeletal protein binding (PKD2L1) endoplasmic reticulum (PKD2L1) plasma membrane (PKD2L1)
Anatomy Link Frequency
papillae 3
PCL 1
nasal 1
taste bud 1
phagocytes 1
PKD2L1 (Homo sapiens)
Pain Link Frequency Relevance Heat
sodium channel 138 96.44 Very High Very High Very High
imagery 13 96.20 Very High Very High Very High
Pain 14 94.88 High High
ASIC 152 88.88 High High
unmyelinated 1 75.20 Quite High
Inflammation 15 69.28 Quite High
Arthritis 4 34.16 Quite Low
Lasting pain 1 27.04 Quite Low
Analgesic 2 25.00 Low Low
agonist 6 21.92 Low Low
Disease Link Frequency Relevance Heat
Leishmaniasis 122 100.00 Very High Very High Very High
Pain 11 94.88 High High
Obstructive Sleep Apnea 146 92.88 High High
Acidosis 2 91.72 High High
Disease 21 88.08 High High
Stress 42 74.24 Quite High
Cv Unclassified Under Development 1 69.72 Quite High
INFLAMMATION 19 69.28 Quite High
Cicatrix 2 61.84 Quite High
Injury 64 58.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our RT-PCR results, wherein evidence of transcripts for both PKD2L1 and PKD1L3 was detected in human fungiform papillae of normal subjects (Figure 2), are consistent with our immunohistochemical results.
Gene_expression (detected) of PKD2L1 in papillae
1) Confidence 0.63 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2754526 Disease Relevance 0 Pain Relevance 0
The latter data show only PKD2L1 in taste bud cells (Panel H) and PKD1L3 in areas of the fungiform papillae other than the taste bud cells (Panel I).
Gene_expression (show) of PKD2L1 in taste bud
2) Confidence 0.63 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2754526 Disease Relevance 0 Pain Relevance 0.03
Also not detected in the fungiform cDNA of Patient 8689 were the two channels, PKD1L3 and PKD2L1, even after 50 cycles of amplification (Figure 2, Lanes C and F).
Neg (not) Gene_expression (detected) of PKD2L1
3) Confidence 0.63 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2754526 Disease Relevance 0 Pain Relevance 0.09
Patient 8716 also did not express transcripts for PKD1L3 and PKD2L1 (Figure 2, Lanes D and G).
Neg (not) Gene_expression (express) of PKD2L1
4) Confidence 0.57 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2754526 Disease Relevance 0 Pain Relevance 0.30
Therefore, PKD2L1 was present in the patient's genome but not expressed in the peripheral tissue of the taste papillae.
Neg (not) Gene_expression (expressed) of PKD2L1 in papillae
5) Confidence 0.57 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2754526 Disease Relevance 0 Pain Relevance 0.08
Therefore, PKD2L1 was present in the patient's genome but not expressed in the peripheral tissue of the taste papillae.
Neg (not) Gene_expression (present) of PKD2L1 in papillae
6) Confidence 0.57 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2754526 Disease Relevance 0 Pain Relevance 0.08
Arthroscopic resection of the PCL was carried out, with immediate relief of his symptoms.
Gene_expression (resection) of PCL in PCL
7) Confidence 0.57 Published 2010 Journal Knee Surg Sports Traumatol Arthrosc Section Abstract Doc Link 19730816 Disease Relevance 0.27 Pain Relevance 0.32
Presentation of PKDL is diverse, may develop in a few cases without previous obvious VL, and can involve other post kala azar manifestations in oral, ocular and nasal tissues.
Gene_expression (Presentation) of PKDL in nasal associated with leishmaniasis
8) Confidence 0.28 Published 2007 Journal Kinetoplastid Biol Dis Section Body Doc Link PMC2000869 Disease Relevance 1.44 Pain Relevance 0
Furthermore, PLC surgery is generally performed in a setting with ACL or PCL reconstruction, and very little literature is available describing clinical results of isolated PLC reconstruction.
Gene_expression (reconstruction) of PCL
9) Confidence 0.21 Published 2010 Journal J Orthop Traumatol Section Body Doc Link PMC2896579 Disease Relevance 0.39 Pain Relevance 0
Other acid-sensitive channels include TRPV4, TRPC4, TRPC5, TRPP2 (PKD2L1), ionotropic purinoceptors (P2X), inward rectifier K(+) channels, voltage-activated K(+) channels, L-type Ca(2+) channels, hyperpolarization-activated cyclic nucleotide gated channels, gap junction channels, and Cl(-) channels.
Gene_expression (include) of PKD2L1
10) Confidence 0.12 Published 2009 Journal Handb Exp Pharmacol Section Abstract Doc Link 19655111 Disease Relevance 0.35 Pain Relevance 0.21
Total light emission (tCL) – the area under the chemiluminescence intensity curve after the addition of fMLP until its return to baseline and peak time – the time (seconds) from the addition of fMLP to the appearance of pCL were also assessed. rCL and pCL were expressed in arbitrary units (aU) per 104 phagocytes (PMNs and monocytes) present in the assayed sample, while tCL in aU·s/104 phagocytes.
Gene_expression (expressed) of pCL in phagocytes
11) Confidence 0.12 Published 2008 Journal J Negat Results Biomed Section Body Doc Link PMC2607253 Disease Relevance 0 Pain Relevance 0
Unpredictably, in all groups, the tendency (although, insignificant) to present a decreased LBCL (rCL, pCL and tCL) subsequent to sleep was prominent.
Gene_expression (present) of pCL
12) Confidence 0.10 Published 2008 Journal J Negat Results Biomed Section Body Doc Link PMC2607253 Disease Relevance 0.25 Pain Relevance 0

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