INT162074

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Context Info
Confidence 0.42
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 1.05
Pain Relevance 2.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (MC1R) plasma membrane (MC1R) signal transducer activity (MC1R)
MC1R (Homo sapiens)
Pain Link Frequency Relevance Heat
melanocortin 1 receptor 27 100.00 Very High Very High Very High
Inflammation 6 90.12 High High
Inflammatory response 3 80.04 Quite High
Disease Link Frequency Relevance Heat
Necrosis 3 92.64 High High
Cancer 3 92.28 High High
INFLAMMATION 9 90.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We demonstrate that: (1) the constitutive activity of MC1R results in elevated intracellular cAMP level, reduced NF-kappaB activity and decreased TNF-alpha transcription; (2) binding of alpha-MSH to MC1R and the subsequent increase in cAMP production do not inhibit TNFalpha-mediated NF-kappaB activation; (3) MC1R signaling is sufficient to strongly inhibit UVB-induced TNF-alpha expression and this inhibitory effect is further enhanced by alpha-MSH stimulation.
Negative_regulation (decreased) of Transcription (transcription) of MC1R associated with melanocortin 1 receptor
1) Confidence 0.42 Published 2009 Journal Photochem. Photobiol. Section Abstract Doc Link 19656324 Disease Relevance 0.34 Pain Relevance 0.88
We demonstrate that: (1) the constitutive activity of MC1R results in elevated intracellular cAMP level, reduced NF-kappaB activity and decreased TNF-alpha transcription; (2) binding of alpha-MSH to MC1R and the subsequent increase in cAMP production do not inhibit TNFalpha-mediated NF-kappaB activation; (3) MC1R signaling is sufficient to strongly inhibit UVB-induced TNF-alpha expression and this inhibitory effect is further enhanced by alpha-MSH stimulation.
Negative_regulation (reduced) of Transcription (activity) of MC1R associated with melanocortin 1 receptor
2) Confidence 0.42 Published 2009 Journal Photochem. Photobiol. Section Abstract Doc Link 19656324 Disease Relevance 0.35 Pain Relevance 0.88
We demonstrate that: (1) the constitutive activity of MC1R results in elevated intracellular cAMP level, reduced NF-kappaB activity and decreased TNF-alpha transcription; (2) binding of alpha-MSH to MC1R and the subsequent increase in cAMP production do not inhibit TNFalpha-mediated NF-kappaB activation; (3) MC1R signaling is sufficient to strongly inhibit UVB-induced TNF-alpha expression and this inhibitory effect is further enhanced by alpha-MSH stimulation.
Negative_regulation (decreased) of Transcription (activity) of MC1R associated with melanocortin 1 receptor
3) Confidence 0.42 Published 2009 Journal Photochem. Photobiol. Section Abstract Doc Link 19656324 Disease Relevance 0.35 Pain Relevance 0.89

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