INT16210

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Context Info
Confidence 0.54
First Reported 1987
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 14
Total Number 15
Disease Relevance 6.58
Pain Relevance 6.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (LTB4R) signal transducer activity (LTB4R)
Anatomy Link Frequency
granulocytes 2
leukocyte 2
neutrophils 2
macrophages 1
monocytes 1
LTB4R (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory mediators 5 100.00 Very High Very High Very High
lidocaine 20 99.38 Very High Very High Very High
Inflammation 107 99.20 Very High Very High Very High
Morphine 10 99.04 Very High Very High Very High
Dynorphin 2 98.06 Very High Very High Very High
Enkephalin 5 97.66 Very High Very High Very High
Opioid 6 96.96 Very High Very High Very High
Paracetamol 4 95.70 Very High Very High Very High
diclofenac 4 94.92 High High
cINOD 20 94.68 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 119 100.00 Very High Very High Very High
Pancreatic Cancer 68 99.86 Very High Very High Very High
Asthma 206 99.42 Very High Very High Very High
Apoptosis 33 96.48 Very High Very High Very High
Adenocarcinoma 10 93.32 High High
Diabetes Mellitus 4 92.68 High High
Reprotox - General 1 2 91.28 High High
Pressure Volume 2 Under Development 1 90.76 High High
Pain 4 88.88 High High
Arthritis 3 86.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Flufenamic, meclofenamic and tolfenamic acids were about equipotent to inhibit PMN degranulation (IC50S 21-32 microM) and LTB4 release (IC50s 21-25 microM) whereas mefenamic acid achieved similar effects at somewhat higher drug concentrations.
Localization (release) of LTB4 in PMN
1) Confidence 0.54 Published 1994 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 7708126 Disease Relevance 0.15 Pain Relevance 0.59
It is assumed that Met-Enk has a modulating effect on the arachidonic acid metabolism, with a consecutive increase of the LTB4 release.
Localization (release) of LTB4
2) Confidence 0.44 Published 1987 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 3037972 Disease Relevance 0.17 Pain Relevance 0.07
Pancreatic cancer cells secrete LTB4 and LTB4 induces proliferation in these cells [62].
Localization (secrete) of LTB4 associated with pancreatic cancer
3) Confidence 0.42 Published 2008 Journal PPAR Research Section Body Doc Link PMC2631651 Disease Relevance 1.23 Pain Relevance 0
The aim of the present study was to compare the effects of chemically different NSAIDs (diclofenac, indomethacin, ketoprofen, paracetamol, piroxicam and four fenamates: flufenamic, meclofenamic, mefenamic and tolfenamic acids) on human polymorphonuclear leukocyte (PMN) functions, i.e. calcium ionophore A23187-triggered degranulation, leukotriene B4 (LTB4) release, platelet-activating factor (PAF) production and migration towards LTB4.
Localization (release) of LTB4 in platelet associated with paracetamol, cinod and diclofenac
4) Confidence 0.41 Published 1994 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 7708126 Disease Relevance 0.16 Pain Relevance 0.56
It also inhibits the release of 5-HETE and LTB4 from human neutrophils stimulated with calcium ionophore and antagonizes the response of tissues to certain prostaglandins.
Localization (release) of LTB4 in neutrophils
5) Confidence 0.24 Published 1991 Journal Clin J Pain Section Abstract Doc Link 1810520 Disease Relevance 0.53 Pain Relevance 0.48
Pancreatic cancer cells secrete LTB4 and LTB4 induces proliferation in these cells [62].
Localization (secrete) of LTB4 associated with pancreatic cancer
6) Confidence 0.19 Published 2008 Journal PPAR Research Section Body Doc Link PMC2631651 Disease Relevance 1.23 Pain Relevance 0
None of the opioid peptides tested [(D-Ala2, D-Leu5)-enkephalin (DADL), (D-Ala2, N-Me-Phe4, Gly-ol5)-enkephalin (DAGO) or dynorphin 1-9 (Dyn 1-9)] was capable of mimicking morphine effects, while Dyn 1-9 per se induced TxB2 and LTB4 secretion from granulocytes.
Localization (secretion) of LTB4 in granulocytes associated with dynorphin, enkephalin, opioid and morphine
7) Confidence 0.09 Published 1990 Journal Inflammation Section Abstract Doc Link 1982531 Disease Relevance 0.07 Pain Relevance 1.06
Morphine was found to inhibit human granulocyte aggregation and ATP, thromboxane B2 (TxB2), and leukotriene B4 (LTB4) secretion during cell aggregation.
Localization (secretion) of LTB4 in granulocyte associated with morphine
8) Confidence 0.08 Published 1990 Journal Inflammation Section Abstract Doc Link 1982531 Disease Relevance 0.07 Pain Relevance 0.96
Similarly, in the work of Wenzel et al, a single dose of oral prednisone inhibited LTB4 release from alveolar macrophages from patients with nocturnal asthma but not from those without nocturnal asthma [30].
Localization (release) of LTB4 in alveolar macrophages associated with asthma
9) Confidence 0.04 Published 2010 Journal Respir Res Section Body Doc Link PMC2894769 Disease Relevance 0.74 Pain Relevance 0.21
Inhibitory effects of amide local anaesthetics on stimulus-induced human leukocyte metabolic activation, LTB4 release and IL-1 secretion in vitro.
Localization (release) of LTB4 in leukocyte
10) Confidence 0.03 Published 1993 Journal Acta Anaesthesiol Scand Section Title Doc Link 8383401 Disease Relevance 0.18 Pain Relevance 0.47
Pretreatment of suspended PMNGs and monocytes with the anaesthetics caused a marked inhibition of LTB4 release when the cells were stimulated with SOZ.
Localization (release) of LTB4 in monocytes
11) Confidence 0.03 Published 1993 Journal Acta Anaesthesiol Scand Section Abstract Doc Link 8383401 Disease Relevance 0.16 Pain Relevance 0.52
Inhibitory effects of amide local anaesthetics on stimulus-induced human leukocyte metabolic activation, LTB4 release and IL-1 secretion in vitro.
Localization (secretion) of LTB4 in leukocyte
12) Confidence 0.03 Published 1993 Journal Acta Anaesthesiol Scand Section Title Doc Link 8383401 Disease Relevance 0.18 Pain Relevance 0.47
This indicates that the baseline contribution of LTB4 from macrophages is unlikely to explain this increased levels found in BAL of severe asthma patients; however, following ex vivo stimulation of macrophages from severe asthma patients, greater levels of LTB4 were released compared to non-severe asthma patients.
Localization (released) of LTB4 in macrophages associated with asthma
13) Confidence 0.03 Published 2010 Journal Respir Res Section Body Doc Link PMC2894769 Disease Relevance 1.33 Pain Relevance 0.22
Both lidocaine and bupivacaine inhibited the release of the inflammatory mediators leukotriene B4 (LTB4) and interleukin-1 (IL-1) evaluated by radioimmunoassay (RIA).
Localization (release) of LTB4 associated with inflammatory mediators and lidocaine
14) Confidence 0.03 Published 1993 Journal Acta Anaesthesiol Scand Section Abstract Doc Link 8383401 Disease Relevance 0.18 Pain Relevance 0.50
HNE-induced LTB4 release through 5-LOX and FLAP upregulation
Localization (release) of LTB4
15) Confidence 0.03 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0.19 Pain Relevance 0.09

General Comments

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