INT16211

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.29
First Reported 1984
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 11
Total Number 20
Disease Relevance 13.00
Pain Relevance 5.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (LTB4R) signal transducer activity (LTB4R)
Anatomy Link Frequency
neutrophil 2
macrophages 1
monocytes 1
parenchyma 1
LTB4R (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 317 100.00 Very High Very High Very High
corticosteroid 310 99.98 Very High Very High Very High
dexamethasone 210 99.98 Very High Very High Very High
diclofenac 4 99.12 Very High Very High Very High
aspirin 2 98.92 Very High Very High Very High
cINOD 20 98.88 Very High Very High Very High
Pain 5 96.24 Very High Very High Very High
Inflammatory mediators 2 93.24 High High
lidocaine 5 90.64 High High
Dismenorea 1 90.00 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 328 100.00 Very High Very High Very High
Asthma 1017 99.72 Very High Very High Very High
Occupational Lung Diseases 370 99.56 Very High Very High Very High
Pressure And Volume Under Development 2 97.12 Very High Very High Very High
Pain 4 96.24 Very High Very High Very High
Atherosclerotic Plaque 3 93.64 High High
Reprotox - General 1 2 91.80 High High
Pressure Volume 2 Under Development 1 91.28 High High
Myocardial Infarction 3 89.40 High High
Nicotine Addiction 40 89.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Indomethacin inhibited LTB4 and PAF synthesis whereas ketoprofen reduced degranulation.
Negative_regulation (inhibited) of LTB4
1) Confidence 0.29 Published 1994 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 7708126 Disease Relevance 0.13 Pain Relevance 0.80
Out of the other NSAIDs, diclofenac (which is chemically related to fenamates) suppressed degranulation as well as LTB4 and PAF production.
Negative_regulation (suppressed) of LTB4 associated with cinod and diclofenac
2) Confidence 0.29 Published 1994 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 7708126 Disease Relevance 0.13 Pain Relevance 0.81
two compounds from the Lilly Research Laboratories potently block LTB4 binding to its receptors within the nM range and inhibit the biological
Negative_regulation (block) of LTB4
3) Confidence 0.26 Published 2008 Journal PPAR Research Section Body Doc Link PMC2631651 Disease Relevance 0.16 Pain Relevance 0.27
It also inhibits the release of 5-HETE and LTB4 from human neutrophils stimulated with calcium ionophore and antagonizes the response of tissues to certain prostaglandins.
Negative_regulation (inhibits) of LTB4 in neutrophils
4) Confidence 0.06 Published 1991 Journal Clin J Pain Section Abstract Doc Link 1810520 Disease Relevance 0.54 Pain Relevance 0.48
Pharmacological characterisation of immunoreactive eicosanoids revealed that in vitro the NSAIDs: aspirin, indomethacin, flurbiprofen and benoxaprofen did not inhibit LTB4 but inhibited TXB2, consistent with cyclo-oxygenase inhibition whereas the prototype mixed inhibitor BW755c inhibited both LTB4 and TXB2.
Negative_regulation (inhibited) of LTB4 associated with aspirin and cinod
5) Confidence 0.06 Published 1986 Journal Prostaglandins Leukot Med Section Abstract Doc Link 3012587 Disease Relevance 0 Pain Relevance 0.14
Pharmacological characterisation of immunoreactive eicosanoids revealed that in vitro the NSAIDs: aspirin, indomethacin, flurbiprofen and benoxaprofen did not inhibit LTB4 but inhibited TXB2, consistent with cyclo-oxygenase inhibition whereas the prototype mixed inhibitor BW755c inhibited both LTB4 and TXB2.
Negative_regulation (inhibit) of LTB4 associated with aspirin and cinod
6) Confidence 0.05 Published 1986 Journal Prostaglandins Leukot Med Section Abstract Doc Link 3012587 Disease Relevance 0 Pain Relevance 0.15
All three drugs tested inhibited the cyclooxygenase activity of the parenchyma as assessed by inhibition of LTB4- and LTD4-induced contraction.
Negative_regulation (inhibition) of LTB4 in parenchyma
7) Confidence 0.05 Published 1984 Journal Inflammation Section Abstract Doc Link 6240459 Disease Relevance 0.09 Pain Relevance 0.09
Chronic oral corticosteroid therapy may lead to a suppression of eicosanoid biosynthesis and could underlie the baseline reduction in LXA4 and LTB4 observed in the macrophages from patients with severe asthma.
Negative_regulation (reduction) of LTB4 in macrophages associated with asthma and corticosteroid
8) Confidence 0.03 Published 2010 Journal Respir Res Section Body Doc Link PMC2894769 Disease Relevance 1.00 Pain Relevance 0.13
However, as far as the AM is concerned, there was no significant inhibition of LTB4 from AMs of normal subjects treated with oral prednisolone despite the fact that direct incubation of these cells with dexamethasone leads to an inhibition of basal and calcium ionophore triggered formation of LTB4 [36].
Negative_regulation (inhibition) of LTB4 associated with dexamethasone
9) Confidence 0.03 Published 2010 Journal Respir Res Section Body Doc Link PMC2894769 Disease Relevance 0.88 Pain Relevance 0.14
Corticosteroid suppression of LXA4. and LTB4
Negative_regulation (suppression) of LTB4 associated with corticosteroid
10) Confidence 0.03 Published 2010 Journal Respir Res Section Body Doc Link PMC2894769 Disease Relevance 0.75 Pain Relevance 0.18
However, ex-vivo treatment of BAL cells with prednislone did cause inhibition of LTB4 and thromboxane generation.
Negative_regulation (inhibition) of LTB4
11) Confidence 0.03 Published 2010 Journal Respir Res Section Body Doc Link PMC2894769 Disease Relevance 0.76 Pain Relevance 0.18
Dexamethasone suppression of LTB4 was observed in all three groups: normal subjects (LPS: 102 ± 23 versus LPS and dexamethasone: 11.6 ± 7.7 pg/ml, p < 0.05); non-severe asthmatics (183 ± 122 versus 21.4 ± 22 pg/ml, p < 0.05) and severe asthmatics (230 ± 102 versus 60 ± 32 pg/ml, p < 0.01).
Negative_regulation (suppression) of LTB4 associated with occupational lung diseases and dexamethasone
12) Confidence 0.03 Published 2010 Journal Respir Res Section Body Doc Link PMC2894769 Disease Relevance 0.81 Pain Relevance 0.19
In addition, while the LPS-induced LTB4 was largely suppressed by dexamethasone, it was only partly suppressed in AMs from severe asthma patients; by contrast, induced generation of LXA4 was suppressed in all three groups.
Negative_regulation (suppressed) of LTB4 associated with asthma and dexamethasone
13) Confidence 0.02 Published 2010 Journal Respir Res Section Body Doc Link PMC2894769 Disease Relevance 1.33 Pain Relevance 0.29
Both LTB4 and LXA4 stimulated by calcium ionophore in the circulating neutrophil was reduced in corticosteroid-dependent asthmatics who were on oral prednisolone [35].
Negative_regulation (reduced) of LTB4 in neutrophil associated with corticosteroid and occupational lung diseases
14) Confidence 0.02 Published 2010 Journal Respir Res Section Body Doc Link PMC2894769 Disease Relevance 1.03 Pain Relevance 0.14
Our study shows reduced baseline LTB4 in non-severe asthma and no significant differences in stimulated production by LPS compared to non-asthmatics.
Negative_regulation (reduced) of LTB4 associated with asthma and occupational lung diseases
15) Confidence 0.02 Published 2010 Journal Respir Res Section Body Doc Link PMC2894769 Disease Relevance 1.17 Pain Relevance 0.03
Dexamethasone inhibited LPS-induced LTB4 and LXA4, with lesser suppression of LTB4 in severe asthma patients (p < 0.05).
Negative_regulation (suppression) of LTB4 associated with asthma and dexamethasone
16) Confidence 0.02 Published 2010 Journal Respir Res Section Abstract Doc Link PMC2894769 Disease Relevance 0.98 Pain Relevance 0.23
Basal levels of LTB4 were decreased in severe asthmatics compared to normal subjects (p < 0.05), but not to non-severe asthma.
Neg (not) Negative_regulation (decreased) of LTB4 associated with asthma and occupational lung diseases
17) Confidence 0.02 Published 2010 Journal Respir Res Section Abstract Doc Link PMC2894769 Disease Relevance 1.02 Pain Relevance 0.23
Pretreatment of suspended PMNGs and monocytes with the anaesthetics caused a marked inhibition of LTB4 release when the cells were stimulated with SOZ.
Negative_regulation (inhibition) of LTB4 in monocytes
18) Confidence 0.02 Published 1993 Journal Acta Anaesthesiol Scand Section Abstract Doc Link 8383401 Disease Relevance 0.16 Pain Relevance 0.52
Hakonarson et al. [63] conducted a randomized, placebo-controlled, crossover trial about DG-031 on 268 patients and found a significant dose-dependent suppression of inflammatory biomarkers (LTB4 and myeloperoxidase) associated with the risk of MI.
Negative_regulation (suppression) of LTB4 associated with inflammation
19) Confidence 0.01 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2817543 Disease Relevance 0.96 Pain Relevance 0.15
Bogani and colleagues [73] found a decrease in TXB2 and LTB4 concentrations with increasing phenolic concentration of the olive oil.
Negative_regulation (decrease) of LTB4
20) Confidence 0.01 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2852848 Disease Relevance 1.09 Pain Relevance 0.47

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox