INT16212

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Context Info
Confidence 0.39
First Reported 1990
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 1.90
Pain Relevance 3.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (LTB4R) signal transducer activity (LTB4R)
Anatomy Link Frequency
neutrophils 4
granulocyte 2
monocytes 2
alveolar macrophages 2
LTB4R (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory mediators 2 100.00 Very High Very High Very High
Morphine 5 99.72 Very High Very High Very High
lidocaine 10 99.66 Very High Very High Very High
Opioid 3 96.96 Very High Very High Very High
Enkephalin 2 93.68 High High
Dismenorea 1 90.00 High High
Pain 2 89.40 High High
analgesia 1 88.48 High High
Dynorphin 1 88.16 High High
Arthritis 1 87.12 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 38 100.00 Very High Very High Very High
Asthma 101 97.76 Very High Very High Very High
Reprotox - General 1 2 91.80 High High
Pressure Volume 2 Under Development 1 91.28 High High
Pain 1 89.40 High High
Arthritis 1 87.12 High High
Occupational Lung Diseases 37 70.04 Quite High
Nicotine Addiction 4 50.60 Quite High
Apoptosis 1 6.92 Low Low
Adhesions 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Flufenamic, meclofenamic and tolfenamic acids were about equipotent to inhibit PMN degranulation (IC50S 21-32 microM) and LTB4 release (IC50s 21-25 microM) whereas mefenamic acid achieved similar effects at somewhat higher drug concentrations.
Negative_regulation (inhibit) of Localization (release) of LTB4 in PMN
1) Confidence 0.39 Published 1994 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 7708126 Disease Relevance 0.15 Pain Relevance 0.59
It also inhibits the release of 5-HETE and LTB4 from human neutrophils stimulated with calcium ionophore and antagonizes the response of tissues to certain prostaglandins.
Negative_regulation (inhibits) of Localization (release) of LTB4 in neutrophils
2) Confidence 0.14 Published 1991 Journal Clin J Pain Section Abstract Doc Link 1810520 Disease Relevance 0.54 Pain Relevance 0.48
Morphine was found to inhibit human granulocyte aggregation and ATP, thromboxane B2 (TxB2), and leukotriene B4 (LTB4) secretion during cell aggregation.
Negative_regulation (inhibit) of Localization (secretion) of LTB4 in granulocyte associated with morphine
3) Confidence 0.04 Published 1990 Journal Inflammation Section Abstract Doc Link 1982531 Disease Relevance 0.07 Pain Relevance 0.96
Similarly, in the work of Wenzel et al, a single dose of oral prednisone inhibited LTB4 release from alveolar macrophages from patients with nocturnal asthma but not from those without nocturnal asthma [30].
Negative_regulation (inhibited) of Localization (release) of LTB4 in alveolar macrophages associated with asthma
4) Confidence 0.03 Published 2010 Journal Respir Res Section Body Doc Link PMC2894769 Disease Relevance 0.79 Pain Relevance 0.21
Pretreatment of suspended PMNGs and monocytes with the anaesthetics caused a marked inhibition of LTB4 release when the cells were stimulated with SOZ.
Negative_regulation (inhibition) of Localization (release) of LTB4 in monocytes
5) Confidence 0.02 Published 1993 Journal Acta Anaesthesiol Scand Section Abstract Doc Link 8383401 Disease Relevance 0.16 Pain Relevance 0.52
Both lidocaine and bupivacaine inhibited the release of the inflammatory mediators leukotriene B4 (LTB4) and interleukin-1 (IL-1) evaluated by radioimmunoassay (RIA).
Negative_regulation (inhibited) of Localization (release) of LTB4 associated with inflammatory mediators and lidocaine
6) Confidence 0.02 Published 1993 Journal Acta Anaesthesiol Scand Section Abstract Doc Link 8383401 Disease Relevance 0.18 Pain Relevance 0.50

General Comments

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