INT162124

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Context Info
Confidence 0.45
First Reported 2005
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 3
Total Number 6
Disease Relevance 0.77
Pain Relevance 1.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Egf) plasma membrane (Egf)
Egf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
sSRI 6 89.88 High High
Hyperalgesia 42 89.20 High High
Serotonin 4 88.52 High High
fluoxetine 8 88.00 High High
Pain 39 75.00 Quite High
nociceptor 33 71.84 Quite High
antidepressant 2 25.00 Low Low
depression 2 25.00 Low Low
withdrawal 18 5.00 Very Low Very Low Very Low
agonist 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Starvation 6 99.32 Very High Very High Very High
Nociception 66 95.36 Very High Very High Very High
Hyperalgesia 42 89.20 High High
Pain 39 75.00 Quite High
Depression 2 25.00 Low Low
INFLAMMATION 10 5.00 Very Low Very Low Very Low
Wound Healing 9 5.00 Very Low Very Low Very Low
Injury 6 5.00 Very Low Very Low Very Low
Cancer 6 5.00 Very Low Very Low Very Low
Apoptosis 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This was determined as phosphorylation (stimulation) of extracellular-regulated kinase 1 and 2 (ERK(1/2)) by transactivation-mediated phosphorylation of the epidermal growth factor (EGF) receptor, followed by conventional EGF receptor signaling (Li et al., Psychopharmacology 194:333-334, 2007).
Positive_regulation (mediated) of Phosphorylation (phosphorylation) of epidermal growth factor
1) Confidence 0.45 Published 2009 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 19662385 Disease Relevance 0 Pain Relevance 0.39
This was determined as phosphorylation (stimulation) of extracellular-regulated kinase 1 and 2 (ERK(1/2)) by transactivation-mediated phosphorylation of the epidermal growth factor (EGF) receptor, followed by conventional EGF receptor signaling (Li et al., Psychopharmacology 194:333-334, 2007).
Spec (determined) Positive_regulation (transactivation) of Phosphorylation (phosphorylation) of epidermal growth factor
2) Confidence 0.45 Published 2009 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 19662385 Disease Relevance 0 Pain Relevance 0.39
Also starvation prior to EGF stimulation did not result in EGF induced Erk1/2 phosphorylation (data not shown).
Positive_regulation (induced) of Phosphorylation (phosphorylation) of EGF associated with starvation
3) Confidence 0.41 Published 2010 Journal Mol Pain Section Body Doc Link PMC3023724 Disease Relevance 0.28 Pain Relevance 0
Nevertheless, we could not detect any EGF induced Erk1/2 phosphorylation.
Neg (not) Positive_regulation (induced) of Phosphorylation (phosphorylation) of EGF
4) Confidence 0.41 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC3023724 Disease Relevance 0.22 Pain Relevance 0.36
Also starvation prior to EGF stimulation did not result in EGF induced Erk1/2 phosphorylation (data not shown).
Neg (not) Positive_regulation (result) of Phosphorylation (phosphorylation) of EGF associated with starvation
5) Confidence 0.41 Published 2010 Journal Mol Pain Section Body Doc Link PMC3023724 Disease Relevance 0.28 Pain Relevance 0
Decorin can cause the rapid phosphorylation of EGF with the concurrent activation of mitogen-activated kinase protein kinase signal pathway.
Positive_regulation (cause) of Phosphorylation (phosphorylation) of EGF
6) Confidence 0.28 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC548144 Disease Relevance 0 Pain Relevance 0

General Comments

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