INT162139

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Context Info
Confidence 0.14
First Reported 2009
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.51
Pain Relevance 1.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (CRX)
Anatomy Link Frequency
ACC 2
CRX (Homo sapiens)
Pain Link Frequency Relevance Heat
Analgesic 6 100.00 Very High Very High Very High
adenocard 4 100.00 Very High Very High Very High
Anterior cingulate cortex 3 100.00 Very High Very High Very High
Glutamate 2 100.00 Very High Very High Very High
antagonist 1 100.00 Very High Very High Very High
Dorsal horn 1 97.44 Very High Very High Very High
nMDA receptor antagonist 1 90.48 High High
nMDA receptor 1 88.00 High High
Central nervous system 3 87.80 High High
amygdala 44 84.44 Quite High
Disease Link Frequency Relevance Heat
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

60 100.00 Very High Very High Very High
Neuroleptic Malignant Syndrome 2 88.52 High High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

5 81.36 Quite High
Nociception 3 79.92 Quite High
Congenital Anomalies 3 78.08 Quite High
Dyspepsia 3 75.00 Quite High
Abdominal Pain 3 67.28 Quite High
Anxiety Disorder 12 66.52 Quite High
Disease 1 15.32 Low Low
Stress 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results showed that 8 cycles of CRD at 40 mmHg and then 8 cycles at 60 mmHg caused no significant alteration in the architecture of the colonic mucosa compared to naïve controls (Figure 1) in any colonic region examined and confirmed that there was no change in the histological score between control and treated rats (Score?
Neg (no) Positive_regulation (caused) of Gene_expression (cycles) of CRD
1) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797306 Disease Relevance 0.21 Pain Relevance 0.42
PF could also reverse the CRD-evoked increased glutamate concentration by CRD as shown by dynamic microdialysis monitoring in ACC, whereas, DPCPX, an antagonist of adenosine A(1) receptor, significantly blocked the analgesic effect of PF and PF's inhibition on CRD-induced p-ERK and p-CREB expression.
Positive_regulation (increased) of Gene_expression (expression) of CRD in ACC associated with adenocard, glutamate, analgesic, antagonist and anterior cingulate cortex
2) Confidence 0.05 Published 2009 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 19664651 Disease Relevance 0.46 Pain Relevance 1.29

General Comments

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