INT162140

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Context Info
Confidence 0.06
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 1.26
Pain Relevance 2.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (CRX)
Anatomy Link Frequency
ACC 4
CRX (Homo sapiens)
Pain Link Frequency Relevance Heat
Analgesic 12 100.00 Very High Very High Very High
adenocard 8 100.00 Very High Very High Very High
Anterior cingulate cortex 6 100.00 Very High Very High Very High
Glutamate 4 100.00 Very High Very High Very High
antagonist 2 100.00 Very High Very High Very High
Dorsal horn 2 98.56 Very High Very High Very High
nMDA receptor antagonist 2 96.72 Very High Very High Very High
Central nervous system 6 94.04 High High
nMDA receptor 2 88.00 High High
Visceral pain 4 87.60 High High
Disease Link Frequency Relevance Heat
Neuroleptic Malignant Syndrome 4 94.76 High High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

4 87.60 High High
Nociception 4 86.16 High High
Dyspepsia 4 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PF could similarly inhibit CRD-evoked p-ERK and c-Fos expression in laminae I-II of the lumbosacral dorsal horn and anterior cingulate cortex (ACC).
Negative_regulation (inhibit) of Gene_expression (expression) of CRD in ACC associated with dorsal horn and anterior cingulate cortex
1) Confidence 0.06 Published 2009 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 19664651 Disease Relevance 0.49 Pain Relevance 1.19
PF could also reverse the CRD-evoked increased glutamate concentration by CRD as shown by dynamic microdialysis monitoring in ACC, whereas, DPCPX, an antagonist of adenosine A(1) receptor, significantly blocked the analgesic effect of PF and PF's inhibition on CRD-induced p-ERK and p-CREB expression.
Negative_regulation (reverse) of Gene_expression (expression) of CRD in ACC associated with adenocard, glutamate, analgesic, antagonist and anterior cingulate cortex
2) Confidence 0.04 Published 2009 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 19664651 Disease Relevance 0.46 Pain Relevance 1.29

General Comments

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