INT162141

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Context Info
Confidence 0.11
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 4.24
Pain Relevance 1.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (CRX)
CRX (Homo sapiens)
Pain Link Frequency Relevance Heat
Glutamate 3 100.00 Very High Very High Very High
nMDA receptor 1 99.64 Very High Very High Very High
adenocard 4 99.42 Very High Very High Very High
Analgesic 6 98.60 Very High Very High Very High
antagonist 1 89.88 High High
Anterior cingulate cortex 3 88.64 High High
Dorsal horn 1 81.96 Quite High
nud 2 75.00 Quite High
nMDA receptor antagonist 1 75.00 Quite High
Central nervous system 3 72.32 Quite High
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 270 100.00 Very High Very High Very High
Disease 35 100.00 Very High Very High Very High
Dyslipidemia /

Combined Dyslipidemia

3 97.88 Very High Very High Very High
Intrauterine Growth Retardation 3 92.56 High High
Hypolipidemia 84 87.96 High High
Diarrhoea 30 82.72 Quite High
Dyspepsia 2 75.00 Quite High
Vomiting 9 74.88 Quite High
Pressure And Volume Under Development 3 73.12 Quite High
Neuroleptic Malignant Syndrome 2 73.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Secondly, in CRD, the chylomicrons are not secreted in the classic COP II way, but are built into the RE.
Neg (not) Localization (secreted) of CRD associated with disorder of lipid metabolism
1) Confidence 0.11 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2956717 Disease Relevance 1.32 Pain Relevance 0
The major clinical and biological manifestations as well as complications are summarized in Table 1 and steps to diagnose CRD are presented in Table 2.


Localization (presented) of CRD associated with disorder of lipid metabolism
2) Confidence 0.10 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2956717 Disease Relevance 1.37 Pain Relevance 0
Recently, the SAR1B gene was identified as responsible for CRD or Anderson's disease (MIM #607689) [8].
Localization (disease) of CRD associated with disease and disorder of lipid metabolism
3) Confidence 0.10 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2956717 Disease Relevance 0.95 Pain Relevance 0
In contrast to ADAM proteins, in which the CRD is followed by epidermal growth factor (EGF)-like repeats, a transmembrane domain and C-terminal cytosolic region, all ADAMTS proteinases possess instead a cysteine-free 'spacer' region.
Localization (followed) of CRD
4) Confidence 0.08 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175049 Disease Relevance 0 Pain Relevance 0
These results suggest that PF's analgesic effect is possibly mediated by adenosine A(1) receptor by inhibiting CRD-evoked glutamate release and the NMDA receptor dependent ERK signaling.
Localization (release) of CRD associated with glutamate, adenocard, nmda receptor and analgesic
5) Confidence 0.07 Published 2009 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 19664651 Disease Relevance 0.38 Pain Relevance 1.16

General Comments

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