INT16220

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Context Info
Confidence 0.42
First Reported 1982
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 13
Total Number 13
Disease Relevance 3.59
Pain Relevance 4.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gh) signal transduction (Gh) mitochondrion (Gh)
extracellular space (Gh) extracellular region (Gh) plasma membrane (Gh)
Anatomy Link Frequency
plasma 2
pituitary 2
central nervous system 2
Gh (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 1 99.76 Very High Very High Very High
Clonidine 15 99.64 Very High Very High Very High
Narcan 26 99.04 Very High Very High Very High
Antagonist 22 97.66 Very High Very High Very High
Desipramine 5 97.52 Very High Very High Very High
GABAergic 4 95.76 Very High Very High Very High
agonist 10 93.64 High High
opiate 3 91.08 High High
opioid 9 84.04 Quite High
endogenous opioid 3 83.28 Quite High
Disease Link Frequency Relevance Heat
Stress 1 100.00 Very High Very High Very High
Sickle Cell Anemia 11 99.86 Very High Very High Very High
Obesity 61 99.84 Very High Very High Very High
Cancer 2 97.44 Very High Very High Very High
Eating Disorder 9 96.04 Very High Very High Very High
Hypothyroidism 1 94.92 High High
Hypoglycemia 5 94.52 High High
Prolactinoma 2 93.36 High High
Insulin Resistance 18 91.68 High High
Congenital Anomalies 2 91.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A significant reduction in the GH response occurred during the second and third weeks of treatment with desipramine.
Negative_regulation (reduction) of Regulation (response) of GH associated with desipramine
1) Confidence 0.42 Published 1982 Journal Br J Psychiatry Section Abstract Doc Link 6293637 Disease Relevance 0.17 Pain Relevance 0.52
These data suggest an impaired adrenergic control of GH and B-EP secretion in children with simple exogenous obesity.
Negative_regulation (impaired) of Regulation (control) of GH associated with obesity
2) Confidence 0.34 Published 1988 Journal Horm. Metab. Res. Section Abstract Doc Link 2971010 Disease Relevance 0.43 Pain Relevance 0.27
The 'post-inhibition' GH rebound after NE treatment and its sensitivity to sGnRH potentiation may also represent a novel mechanism for GH regulation in fish.
Negative_regulation (mechanism) of Regulation (regulation) of GH
3) Confidence 0.28 Published 2000 Journal J. Neuroendocrinol. Section Abstract Doc Link 10718928 Disease Relevance 0 Pain Relevance 0.39
A control test using saline showed that the PRL and GH responses to insulin stress were impaired in obese subjects, whereas no difference was seen in the cortisol response.
Negative_regulation (impaired) of Regulation (responses) of GH associated with stress and obesity
4) Confidence 0.26 Published 1989 Journal J. Endocrinol. Invest. Section Abstract Doc Link 2693516 Disease Relevance 0.84 Pain Relevance 0.57
When naloxone was given together with sodium valproate, both GH and PRL responses to exercise were abolished completely.
Negative_regulation (abolished) of Regulation (responses) of GH associated with narcan
5) Confidence 0.20 Published 1994 Journal Eur. J. Endocrinol. Section Abstract Doc Link 8038904 Disease Relevance 0 Pain Relevance 0.82
This conclusion is based on the following findings: 1) The minimum effective IV dose of clonidine or UK 14304 was four times larger for activation of PRL than GH secretion and had already manifest extracentral effects (elevation of arterial BP). 2) Subcutaneous injection of UK 14304 (220 micrograms/kg) elevated plasma GH but not PRL levels indicating that an effective activation of the central alpha 2 receptors does not stimulate PRL release. 3) Peripherally acting alpha 2 agonists (p-aminoclonidine, oxymetazoline) had no effect on GH secretion but stimulated PRL release in a manner identical with the effect of clonidine or UK 14304. 4) The peripherally acting alpha 2 antagonist DG-5128 blocked only the PRL secretory response to UK 14304 whereas the peripherally and centrally active yohimbine blocked the PRL and GH responses.
Negative_regulation (blocked) of Regulation (responses) of GH in plasma associated with antagonist, agonist and clonidine
6) Confidence 0.14 Published 1989 Journal Brain Res. Bull. Section Abstract Doc Link 2575439 Disease Relevance 0 Pain Relevance 0.43
A significant inhibition of the GH response to GHRH was observed during naloxone infusion, similar to the inhibition in normal female subjects during the follicular phase.
Negative_regulation (inhibition) of Regulation (response) of GH associated with narcan
7) Confidence 0.12 Published 1991 Journal Psychoneuroendocrinology Section Abstract Doc Link 1811245 Disease Relevance 0.50 Pain Relevance 0.27
The mean % inhibition of peak GH response was 83% during follicular phase, 46.5% during periovulatory phase, and 77.6% during luteal phase.
Negative_regulation (inhibition) of Regulation (response) of GH
8) Confidence 0.10 Published 1987 Journal Metab. Clin. Exp. Section Abstract Doc Link 3100909 Disease Relevance 0 Pain Relevance 0.64
These data indicate that in EC the impaired GH response to a central nervous system mediated stimulus, the relatively low plasma Sm-C concentrations, and the presence of clinical or subclinical hypothyroidism may contribute to the severity of growth retardation present in this syndrome.
Negative_regulation (impaired) of Regulation (response) of GH in central nervous system associated with hypothyroidism, syndrome and central nervous system
9) Confidence 0.10 Published 1988 Journal J. Endocrinol. Invest. Section Abstract Doc Link 3139739 Disease Relevance 0.26 Pain Relevance 0.21
To diminish the influence of GH, Vestergaard et al. investigate the effects of prolonged ghrelin infusion (not a unique dose) on insulin sensitivity [76] which decreased after few minutes of ghrelin infusion and outlasted both the infusion period and the postinfusion interval.
Negative_regulation (diminish) of Regulation (influence) of GH
10) Confidence 0.09 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2911604 Disease Relevance 0.15 Pain Relevance 0.05
The GH response was abolished by procyclidine in all three groups.
Negative_regulation (abolished) of Regulation (response) of GH
11) Confidence 0.08 Published 2008 Journal Am. J. Gastroenterol. Section Body Doc Link 18785949 Disease Relevance 0 Pain Relevance 0
Response of growth hormone (GH) and adrenocorticotropic hormone (ACTH) to insulin were also impaired.
Negative_regulation (impaired) of Regulation (Response) of growth hormone
12) Confidence 0.04 Published 1985 Journal No To Shinkei Section Abstract Doc Link 4041291 Disease Relevance 0.42 Pain Relevance 0.06
Nine of 21 children with SCD had a defective GH response to both clonidine and glucagon provocation (peak < 10 micrograms/L); these children differed from the 12 others in having slower linear growth velocity (GV and GVSDS), lower circulating concentrations of IGF-I and IGFBP-3, and either partial or complete empty sellae in computed tomographic scans of the hypothalamic-pituitary area.
Negative_regulation (defective) of Regulation (response) of GH in pituitary associated with sickle cell anemia and clonidine
13) Confidence 0.03 Published 1997 Journal Metab. Clin. Exp. Section Abstract Doc Link 9361679 Disease Relevance 0.81 Pain Relevance 0.10

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