INT16221

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Context Info
Confidence 0.21
First Reported 1987
Last Reported 2002
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 11
Disease Relevance 1.89
Pain Relevance 4.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ghrh, Gh) extracellular region (Ghrh, Gh) cytosol (Gh)
signal transduction (Gh) mitochondrion (Gh) plasma membrane (Gh)
Ghrh (Rattus norvegicus)
Gh (Mus musculus)
Pain Link Frequency Relevance Heat
Clonidine 12 99.80 Very High Very High Very High
narcan 24 99.72 Very High Very High Very High
Somatostatin 4 99.56 Very High Very High Very High
antagonist 14 99.38 Very High Very High Very High
tetrodotoxin 6 99.24 Very High Very High Very High
opioid receptor 4 99.16 Very High Very High Very High
opiate 2 98.20 Very High Very High Very High
Neurotransmitter 3 96.48 Very High Very High Very High
Potency 2 82.32 Quite High
agonist 6 75.00 Quite High
Disease Link Frequency Relevance Heat
Eating Disorder 7 99.96 Very High Very High Very High
Panic Disorder 4 99.90 Very High Very High Very High
Obesity 4 99.52 Very High Very High Very High
Polycystic Ovary Syndrome 8 98.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
OBJECTIVE: To investigate the effect of naloxone, an opioid receptor antagonist, on the release of growth hormone (GH) induced by the growth hormone-releasing hormone (GHRH) in normal-weight and obese women with PCOS in relation to feeding.
growth hormone-releasing hormone Positive_regulation (induced) of growth hormone associated with antagonist, obesity, narcan, polycystic ovary syndrome and opioid receptor
1) Confidence 0.21 Published 2002 Journal Fertil. Steril. Section Abstract Doc Link 12413983 Disease Relevance 0.27 Pain Relevance 0.22
OBJECTIVE: To investigate the effect of naloxone, an opioid receptor antagonist, on the release of growth hormone (GH) induced by the growth hormone-releasing hormone (GHRH) in normal-weight and obese women with PCOS in relation to feeding.
growth hormone-releasing hormone Positive_regulation (induced) of GH associated with antagonist, obesity, narcan, polycystic ovary syndrome and opioid receptor
2) Confidence 0.21 Published 2002 Journal Fertil. Steril. Section Abstract Doc Link 12413983 Disease Relevance 0.27 Pain Relevance 0.22
OBJECTIVE: To investigate the effect of naloxone, an opioid receptor antagonist, on the release of growth hormone (GH) induced by the growth hormone-releasing hormone (GHRH) in normal-weight and obese women with PCOS in relation to feeding.
GHRH Positive_regulation (induced) of growth hormone associated with antagonist, obesity, narcan, polycystic ovary syndrome and opioid receptor
3) Confidence 0.21 Published 2002 Journal Fertil. Steril. Section Abstract Doc Link 12413983 Disease Relevance 0.27 Pain Relevance 0.22
OBJECTIVE: To investigate the effect of naloxone, an opioid receptor antagonist, on the release of growth hormone (GH) induced by the growth hormone-releasing hormone (GHRH) in normal-weight and obese women with PCOS in relation to feeding.
GHRH Positive_regulation (induced) of GH associated with antagonist, obesity, narcan, polycystic ovary syndrome and opioid receptor
4) Confidence 0.21 Published 2002 Journal Fertil. Steril. Section Abstract Doc Link 12413983 Disease Relevance 0.27 Pain Relevance 0.22
The GHRH-induced GH increase, which was not affected by a simultaneous addition of a receptor-operated nonspecific Ca2+ channel antagonist tetramethrine (0.1 mmol/l), was significantly reduced by a voltage-sensitive L-type Ca2+ channel antagonist nifedipine (1 micromol/l).
GHRH Positive_regulation (induced) of GH associated with antagonist
5) Confidence 0.20 Published 1999 Journal Domest. Anim. Endocrinol. Section Abstract Doc Link 10484133 Disease Relevance 0 Pain Relevance 0.32
In freshly isolated and perifused cells, butyrate (10 mmol/l) as well as somatostatin (100 nmol/l) significantly reduced the GH increase induced by GHRH.
GHRH Positive_regulation (increase) of GH associated with somatostatin
6) Confidence 0.19 Published 1999 Journal Domest. Anim. Endocrinol. Section Abstract Doc Link 10484133 Disease Relevance 0 Pain Relevance 0.39
Sex-related naloxone influence on growth hormone-releasing hormone-induced growth hormone secretion in normal subjects.
growth hormone-releasing hormone Positive_regulation (induced) of growth hormone associated with narcan
7) Confidence 0.11 Published 1987 Journal Metab. Clin. Exp. Section Title Doc Link 3100909 Disease Relevance 0 Pain Relevance 0.68
Somatostatin (10(-7) M) inhibited GHRH-stimulated GH secretion and GH mRNA accumulation.
GHRH Positive_regulation (accumulation) of GH associated with somatostatin
8) Confidence 0.07 Published 1994 Journal Proc. Soc. Exp. Biol. Med. Section Abstract Doc Link 7938032 Disease Relevance 0 Pain Relevance 0.74
GH response to GHRH and clonidine stimulation in panic disorder.
GHRH Positive_regulation (response) of GH associated with panic disorder and clonidine
9) Confidence 0.06 Published 1995 Journal Psychoneuroendocrinology Section Title Doc Link 7838898 Disease Relevance 0.29 Pain Relevance 0.34
However, 200 micrograms GHRH-Ant (iv for 75 min) significantly inhibited GH release, which was induced by simultaneous infusion of 5 micrograms GHRH.
GHRH Positive_regulation (induced) of GH
10) Confidence 0.05 Published 1996 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 8626863 Disease Relevance 0 Pain Relevance 0.47
In AN, GHRH induced an increase in GH levels similar to that observed in normal subjects.
GHRH Positive_regulation (increase) of GH associated with eating disorder
11) Confidence 0.03 Published 1991 Journal Psychoneuroendocrinology Section Abstract Doc Link 1811245 Disease Relevance 0.51 Pain Relevance 0.25

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