INT162221

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Context Info
Confidence 0.38
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.09
Pain Relevance 0.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Gria2) plasma membrane (Gria2) protein complex (Gria2)
Gria2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate receptor 1 100.00 Very High Very High Very High
antagonist 4 99.98 Very High Very High Very High
Nucleus accumbens 5 93.40 High High
addiction 2 90.48 High High
tetrodotoxin 2 75.84 Quite High
Dopamine 5 75.00 Quite High
cocaine 1 25.00 Low Low
depression 11 5.00 Very Low Very Low Very Low
imagery 7 5.00 Very Low Very Low Very Low
corticosteroid 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Drug Dependence 1 86.16 High High
Depression 11 5.00 Very Low Very Low Very Low
Stress 4 5.00 Very Low Very Low Very Low
Togavirus Infection 2 5.00 Very Low Very Low Very Low
Shock 1 5.00 Very Low Very Low Very Low
Adhesions 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Prolonged activity blockade (1-3 days) with an AMPA receptor antagonist increased cell surface (synaptic and extrasynaptic) glutamate receptor 1 (GluR1) and GluR2 but not GluR3, as well as GluR1/2 co-localization on the cell surface and total GluR1 and GluR2 protein levels.
Positive_regulation (increased) of Localization (localization) of GluR2 associated with glutamate receptor and antagonist
1) Confidence 0.38 Published 2009 Journal Eur. J. Neurosci. Section Abstract Doc Link 19674091 Disease Relevance 0.09 Pain Relevance 0.58
Corticosterone increases surface mobility of GluR2
Positive_regulation (increases) of Localization (mobility) of GluR2
2) Confidence 0.30 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2659165 Disease Relevance 0 Pain Relevance 0.03

General Comments

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