INT162222

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Context Info
Confidence 0.38
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.64
Pain Relevance 1.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Gria2) plasma membrane (Gria2) protein complex (Gria2)
Anatomy Link Frequency
forebrain 2
Gria2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 12 99.62 Very High Very High Very High
Glutamate 28 91.20 High High
imagery 7 90.40 High High
antagonist 6 83.68 Quite High
Pyramidal cell 1 81.52 Quite High
tetrodotoxin 2 78.16 Quite High
Raphe 1 78.08 Quite High
drug abuse 2 77.48 Quite High
Nucleus accumbens 18 75.00 Quite High
5HT 4 74.32 Quite High
Disease Link Frequency Relevance Heat
Psychosis 4 93.56 High High
Schizophrenia 5 88.64 High High
Urological Neuroanatomy 1 82.64 Quite High
Drug Dependence 5 77.48 Quite High
Depression 12 5.00 Very Low Very Low Very Low
Cognitive Disorder 5 5.00 Very Low Very Low Very Low
Stress 4 5.00 Very Low Very Low Very Low
Togavirus Infection 2 5.00 Very Low Very Low Very Low
Amnesia 2 5.00 Very Low Very Low Very Low
Hallucination 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Repeated dopamine (DA) treatment, which leads to upregulation of surface GluR1 and GluR2, occluded activity blockade-induced synaptic scaling.
Positive_regulation (leads) of Positive_regulation (upregulation) of GluR2 associated with dopamine
1) Confidence 0.38 Published 2009 Journal Eur. J. Neurosci. Section Abstract Doc Link 19674091 Disease Relevance 0 Pain Relevance 0.60
The mRNA level of GluR2 was increased in the forebrain cortex, GluR3 in the CPU, and GluR1 and GluR3 in the hypothalamus.
Positive_regulation (increased) of Positive_regulation (increased) of GluR2 in forebrain
2) Confidence 0.31 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2358913 Disease Relevance 0.64 Pain Relevance 0.50
The corticosterone mediated enhancement of surface GluR2 levels can be attributed to increased exocytosis and/or reduced endocytosis of AMPARs.
Positive_regulation (mediated) of Positive_regulation (enhancement) of GluR2
3) Confidence 0.20 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2659165 Disease Relevance 0 Pain Relevance 0.08

General Comments

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