INT162224

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Context Info
Confidence 0.27
First Reported 2009
Last Reported 2009
Negated 1
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.07
Pain Relevance 0.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Grin1, Gria1) cytosol (Gria1) endoplasmic reticulum (Gria1)
enzyme binding (Grin1) protein complex (Gria1) cytoplasm (Grin1)
Grin1 (Rattus norvegicus)
Gria1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
tetrodotoxin 1 100.00 Very High Very High Very High
Nucleus accumbens 5 99.60 Very High Very High Very High
antagonist 3 99.28 Very High Very High Very High
Glutamate receptor 1 87.40 High High
addiction 2 75.08 Quite High
Dopamine 5 75.00 Quite High
cocaine 1 30.88 Quite Low
Disease Link Frequency Relevance Heat
Drug Dependence 1 70.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
GluR1 and GluR2 surface expression was also increased by tetrodotoxin alone or in combination with an N-methyl-d-aspartate receptor or AMPA receptor antagonist but not by the l-type Ca(2+) channel antagonist nifedipine.
N-methyl-d-aspartate receptor Neg (not) Positive_regulation (increased) of Gene_expression (expression) of GluR1 associated with tetrodotoxin and antagonist
1) Confidence 0.27 Published 2009 Journal Eur. J. Neurosci. Section Abstract Doc Link 19674091 Disease Relevance 0.07 Pain Relevance 0.66

General Comments

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