INT162241

Context Info Confidence 0.03 First Reported 2005 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 0.86 Pain Relevance 0.73

extracellular region (COL7A1, MMP13) peptidase activity (MMP13) extracellular space (MMP13) Golgi apparatus (MMP13) proteinaceous extracellular matrix (MMP13) cell adhesion (COL7A1)

Anatomy Link Frequency articular 1 COL7A1 (Homo sapiens) MMP13 (Homo sapiens)

Pain Link Frequency Relevance Heat metalloproteinase 15 99.52 Angina 12 92.00 rheumatoid arthritis 1 10.48 agonist 6 7.36 cytokine 6 5.00 antagonist 5 5.00 backache 4 5.00 Chronic low back pain 2 5.00 Osteoarthritis 2 5.00 Inflammation 1 5.00

Disease Link Frequency Relevance Heat Atherosclerotic Plaque 1 97.88 Cv General 3 Under Development 12 92.00 Coronary Artery Disease 7 82.16 Intervertebral Disk Degeneration 7 44.12 Volume Depletion And Dehydration 1 34.16 Rheumatoid Arthritis 1 10.48 Disease 3 6.88 Low Back Pain 6 5.00 Death 2 5.00 Necrosis 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

However, among various MMPs, only MMP-1, MMP-8 and MMP-13, so-called interstitial collagenases, can initiate collagen breakdown.

collagen Binding (initiate) of MMP-13 associated with metalloproteinase

1) Confidence 0.03 Published 2010 Journal Atherosclerosis Section Abstract Doc Link 19674746 Disease Relevance 0.86 Pain Relevance 0.73

Treatment of NP (but not AF) cells from degenerate and non-degenerate IVDs with IL-1 resulted in significant increases in gene expression of MMP-13 (an MMP with high affinity for type II collagen), a finding not previously reported in disc cells, although it has been shown in articular chondrocytes [16,47,48].

collagen Binding (affinity) of MMP-13 in articular

2) Confidence 0.01 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175026 Disease Relevance 0 Pain Relevance 0

General Comments

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