INT162249

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Context Info
Confidence 0.12
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 6.46
Pain Relevance 4.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

chromosome (Hist1h2aa) nucleus (Hist1h2aa) DNA binding (Hist1h2aa)
Anatomy Link Frequency
lymph nodes 1
monocytes 1
mesenteric lymph nodes 1
lung 1
T cells 1
Hist1h2aa (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 73 100.00 Very High Very High Very High
electroacupuncture 12 99.38 Very High Very High Very High
Neuritis 12 98.68 Very High Very High Very High
aspirin 78 98.50 Very High Very High Very High
Inflammation 130 97.98 Very High Very High Very High
ketamine 136 97.26 Very High Very High Very High
Inflammatory response 31 92.04 High High
Pain 2 91.76 High High
Sciatic nerve 2 88.48 High High
Neuropathic pain 1 83.00 Quite High
Disease Link Frequency Relevance Heat
Schizophrenia 108 99.84 Very High Very High Very High
Experimental Autoimmune Neuritis 12 98.68 Very High Very High Very High
INFLAMMATION 193 97.98 Very High Very High Very High
Syndrome 33 93.84 High High
Asthma 60 92.48 High High
Pain 2 91.76 High High
Infection 11 90.00 High High
Pressure And Volume Under Development 119 88.72 High High
Stress 17 87.56 High High
Hyperglycemia 1 86.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, it is conceivable that the shift towards TH-2 cytokine production in schizophrenia will be counteracted by inhibition of prostaglandin formation by acetylsalicylic acid.
Gene_expression (production) of TH-2 associated with aspirin, schizophrenia and cytokine
1) Confidence 0.12 Published 2006 Journal Trials Section Body Doc Link PMC1626076 Disease Relevance 0.83 Pain Relevance 0.45
Accordingly, we postulate that the greatest effect of acetylsalicylic acid will therefore be observed in those individuals with the highest relative TH-2 reactivity, i.e. the lowest IFN-?
Gene_expression (reactivity) of TH-2 associated with aspirin
2) Confidence 0.10 Published 2006 Journal Trials Section Body Doc Link PMC1626076 Disease Relevance 0.56 Pain Relevance 0.54
Prostaglandin E2 is known to enhance the production of TH2 cytokines via inhibition of the production of IL-12 by antigen presenting cells such as monocytes [13].
Gene_expression (production) of TH2 in monocytes associated with cytokine
3) Confidence 0.09 Published 2006 Journal Trials Section Body Doc Link PMC1626076 Disease Relevance 0.92 Pain Relevance 0.49
Th1 cytokine (IL-2 and interferon-gamma) production and mRNA expression in splenic T cells of traumatized rats were significantly decreased on postoperative day 3 (P < 0.001, trauma group versus control group), whereas Th2 cytokine (IL-4 and IL-10) production and mRNA expression were increased (P < 0.001).
Gene_expression (production) of Th2 in T cells
4) Confidence 0.03 Published 2009 Journal Anesth. Analg. Section Body Doc Link 19843806 Disease Relevance 0 Pain Relevance 0
Therefore, we investigated the effects of EA on T helper (Th)1/Th2 cytokine production and mRNA expression and evaluated the signaling regulatory mechanism of EA effects.
Gene_expression (production) of Th2 associated with electroacupuncture and cytokine
5) Confidence 0.03 Published 2009 Journal Anesth. Analg. Section Abstract Doc Link 19843806 Disease Relevance 0.27 Pain Relevance 0.45
In lymph nodes of EAN rats, Compound A depressed Th1 and Th17 cytokines, but increased Th2 cytokine and Foxp3 expression.
Gene_expression (expression) of Th2 in lymph nodes associated with neuritis and cytokine
6) Confidence 0.03 Published 2009 Journal J. Immunol. Section Abstract Doc Link 19675162 Disease Relevance 1.86 Pain Relevance 1.52
We found that ketamine treatment yielded anti-inflammatory effects, as evidenced by lung histological examination, total and differential cell counts in BALF, Th2 cytokine levels in BALF, and iNOS expression and NO content in pulmonary tissues.
Gene_expression (expression) of Th2 in lung associated with inflammation, ketamine and cytokine
7) Confidence 0.01 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1876456 Disease Relevance 0.43 Pain Relevance 0.53
and Th2 (IL-4 and IL-10) cytokine production in the small bowel and in the mesenteric lymph nodes [118].
Gene_expression (production) of Th2 in mesenteric lymph nodes associated with cytokine
8) Confidence 0.01 Published 2010 Journal International Journal of Inflammation Section Body Doc Link PMC2990101 Disease Relevance 1.61 Pain Relevance 0.36

General Comments

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