INT162250

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Context Info
Confidence 0.01
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Title
Documents 1
Total Number 2
Disease Relevance 0.80
Pain Relevance 1.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (TRPV1, Grm5) cytosol (TRPV1) signal transduction (Grm5)
transport (TRPV1) cytoplasm (Grm5) signal transducer activity (Grm5)
Anatomy Link Frequency
neurons 1
spinal cord 1
TRPV1 (Homo sapiens)
Grm5 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 8 99.62 Very High Very High Very High
Spinal cord 4 99.20 Very High Very High Very High
Dorsal horn 2 98.44 Very High Very High Very High
Substantia gelatinosa neuron 2 95.36 Very High Very High Very High
Glutamate receptor 2 95.04 Very High Very High Very High
central sensitization 2 56.40 Quite High
Disease Link Frequency Relevance Heat
Nociception 6 98.84 Very High Very High Very High
Pain 6 91.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here we show that TRPV1 on central presynaptic terminals is coupled to mGluR5 in a membrane-delimited manner, thereby contributing to the modulation of nociceptive synaptic transmission in the substantia gelatinosa neurons of the spinal cord.
TRPV1 Binding (coupled) of mGluR5 in spinal cord associated with nociception, substantia gelatinosa neuron and spinal cord
1) Confidence 0.01 Published 2009 Journal J. Neurosci. Section Abstract Doc Link 19675234 Disease Relevance 0.41 Pain Relevance 0.49
Membrane-delimited coupling of TRPV1 and mGluR5 on presynaptic terminals of nociceptive neurons.
TRPV1 Binding (coupling) of mGluR5 in neurons associated with nociception and pain
2) Confidence 0.01 Published 2009 Journal J. Neurosci. Section Title Doc Link 19675234 Disease Relevance 0.39 Pain Relevance 0.54

General Comments

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