INT162254

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Context Info
Confidence 0.41
First Reported 2006
Last Reported 2010
Negated 3
Speculated 1
Reported most in Body
Documents 28
Total Number 30
Disease Relevance 18.12
Pain Relevance 4.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein folding (BAG3) cytosol (BAG3) plasma membrane (BAG3)
cytoplasm (BAG3)
Anatomy Link Frequency
brain 4
blood 1
BAG3 (Homo sapiens)
Pain Link Frequency Relevance Heat
cva 1402 99.86 Very High Very High Very High
anesthesia 129 96.84 Very High Very High Very High
epidural 27 96.40 Very High Very High Very High
ketamine 7 96.00 Very High Very High Very High
Catecholamine 26 95.60 Very High Very High Very High
Versed 29 95.44 Very High Very High Very High
isoflurane 7 93.12 High High
palliative 6 88.16 High High
ischemia 10 70.48 Quite High
cerebral cortex 42 64.40 Quite High
Disease Link Frequency Relevance Heat
Injury 130 99.98 Very High Very High Very High
Cv General 3 Under Development 1348 99.86 Very High Very High Very High
Brain Disease 10 99.66 Very High Very High Very High
Brain Injury 261 99.56 Very High Very High Very High
Myocardial Infarction 83 99.54 Very High Very High Very High
Sleep Disorders 434 99.40 Very High Very High Very High
Soft Tissue Injuries 20 98.58 Very High Very High Very High
Dementia 1 98.12 Very High Very High Very High
Contusions 10 98.00 Very High Very High Very High
Delirium 4 97.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, the administered drugs did not have a strong influence on the BIS and EMG values in the dose in which they were applied in both CPRs, and the EMG remained at the same level despite the application of a small dose of etomidate.
Regulation (values) of BIS
1) Confidence 0.41 Published 2008 Journal Int J Emerg Med Section Body Doc Link PMC2657270 Disease Relevance 0.33 Pain Relevance 0
During the first event the patient had immediately high BIS values under CPR and a good neurological outcome.
Regulation (values) of BIS
2) Confidence 0.41 Published 2008 Journal Int J Emerg Med Section Body Doc Link PMC2657270 Disease Relevance 0.29 Pain Relevance 0.09
In the second course of CPR 8 days later, the patient had low BIS values under CPR, which further decreased.
Regulation (values) of BIS
3) Confidence 0.41 Published 2008 Journal Int J Emerg Med Section Body Doc Link PMC2657270 Disease Relevance 0.35 Pain Relevance 0.11
A larger group of patients needs to be studied to determine the impact of individual brain pathology on outcomes and BIS and StcO2 values.
Regulation (values) of BIS in brain associated with brain disease
4) Confidence 0.40 Published 2006 Journal Crit Care Section Body Doc Link PMC1794465 Disease Relevance 1.19 Pain Relevance 0.17
However Puri has reported paradoxical changes in BIS during N2O administration.22 Previous data regarding the use of BIS during N2O sedation remain insufficient.
Regulation (changes) of BIS associated with sleep disorders
5) Confidence 0.31 Published 2007 Journal European journal of dentistry Section Body Doc Link PMC2609910 Disease Relevance 0.50 Pain Relevance 0.24
Two research showed that no change in BIS or Cerebral State Index value while the participants breathed 70% N2O in O2 although all of them lost consciousness clinically.29,30 In their research on 22 healthy volunteers who were sedated by low N2O, Hall et al21 reported that no correlation was found with OAA/S and BIS.
Neg (no) Regulation (change) of BIS associated with unconsciousness
6) Confidence 0.31 Published 2007 Journal European journal of dentistry Section Body Doc Link PMC2609910 Disease Relevance 0.59 Pain Relevance 0.31
However, the BIS, similar to other EEG-based techniques, can be adversely affected by conditions such as traumatic brain injury, dementia, or delirium which result in EEG slowing [21].
Regulation (affected) of BIS in brain associated with dementia, delirium and brain injury
7) Confidence 0.28 Published 2008 Journal Crit Care Section Body Doc Link PMC2447606 Disease Relevance 0.58 Pain Relevance 0
BIS values were monitored continuously and recorded during each PET scan.
Regulation (values) of BIS
8) Confidence 0.24 Published 2009 Journal Arch Ital Biol Section Abstract Doc Link 19678596 Disease Relevance 0 Pain Relevance 0.11
There are 1,883 concurrent, hourly observations of ICP, CPP, BIS and StcO2 values.
Regulation (values) of BIS associated with cva
9) Confidence 0.20 Published 2006 Journal Crit Care Section Body Doc Link PMC1794465 Disease Relevance 0.77 Pain Relevance 0.31
BIS monitoring was started 11 min after the cardiac arrest and showed an initial BIS value of 87 and an average value of 78?
Regulation (value) of BIS associated with myocardial infarction
10) Confidence 0.18 Published 2008 Journal Int J Emerg Med Section Body Doc Link PMC2657270 Disease Relevance 0.53 Pain Relevance 0.05
EMG levels between 40 and 60 may influence the BIS values and cause false high BIS values [7].
Regulation (values) of BIS
11) Confidence 0.18 Published 2008 Journal Int J Emerg Med Section Body Doc Link PMC2657270 Disease Relevance 0.34 Pain Relevance 0.03
Additionally, increasing BIS values in the early stage of both during and after resuscitation are associated with good survival and sufficient cerebral performance [5, 6].
Regulation (values) of BIS
12) Confidence 0.18 Published 2008 Journal Int J Emerg Med Section Body Doc Link PMC2657270 Disease Relevance 0.24 Pain Relevance 0.04
The hourly StcO2 and BIS values did not influence treatment decisions.
Neg (not) Regulation (values) of BIS
13) Confidence 0.17 Published 2006 Journal Crit Care Section Body Doc Link PMC1794465 Disease Relevance 0.44 Pain Relevance 0.08
Key messages

• Noninvasive BIS and StcO2 values are clinically relevant with severe brain injury. • ICP, BIS, and StcO2 values provide complementary information. • When ICP increases or CPP decreases, there is cerebral hypoxia and altered brain wave patterns. • Future studies will determine the therapeutic and diagnostic benefit of BIS and StcO2 monitoring. • CAP Index is a discriminate relationship between ICP and MAP that has prognostic and therapeutic implications.


Regulation (values) of BIS in brain associated with cerebral hypoxia, cva and brain injury
14) Confidence 0.17 Published 2006 Journal Crit Care Section Body Doc Link PMC1794465 Disease Relevance 1.42 Pain Relevance 0.50
Surviving patients and patients with good neurological outcome have higher BIS and StcO2 values.
Regulation (values) of BIS
15) Confidence 0.17 Published 2006 Journal Crit Care Section Body Doc Link PMC1794465 Disease Relevance 1.18 Pain Relevance 0.55
Severe forehead, soft tissue injury may prohibit BIS or cerebral oximetry sensor application or alter the BIS or StcO2 values.
Regulation (values) of BIS associated with soft tissue injuries
16) Confidence 0.17 Published 2006 Journal Crit Care Section Body Doc Link PMC1794465 Disease Relevance 1.07 Pain Relevance 0.36
Prospective trials need to be performed to assess the hour-to-hour treatment implications of BIS and StcO2 values.
Regulation (values) of BIS
17) Confidence 0.17 Published 2006 Journal Crit Care Section Body Doc Link PMC1794465 Disease Relevance 1.23 Pain Relevance 0.21
The ICP, MAP, BIS, and StcO2 values were recorded hourly for each of the first six post-injury days.
Regulation (values) of BIS associated with injury and cva
18) Confidence 0.17 Published 2006 Journal Crit Care Section Body Doc Link PMC1794465 Disease Relevance 1.23 Pain Relevance 0.29
The study purpose is to determine the relationships between StcO2 and BIS values in severe brain injury and ICU outcomes (survival, discharge Glasgow Coma Scale (GCS) score, ICP, CPP, and interventions to lower ICP).


Spec (determine) Regulation (values) of BIS in brain associated with cva, coma and brain injury
19) Confidence 0.17 Published 2006 Journal Crit Care Section Body Doc Link PMC1794465 Disease Relevance 1.29 Pain Relevance 0.40
These outcomes need to be compared with post-injury BIS and StcO2 values.
Regulation (values) of BIS associated with injury
20) Confidence 0.17 Published 2006 Journal Crit Care Section Body Doc Link PMC1794465 Disease Relevance 1.24 Pain Relevance 0.17

General Comments

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