INT162255

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Context Info
Confidence 0.45
First Reported 2004
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.64
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Tyms) methyltransferase activity (Tyms) aging (Tyms)
mRNA binding (Tyms) nucleolus (Tyms) nucleus (Tyms)
Tyms (Rattus norvegicus)
Pain Link Frequency Relevance Heat
palliative 2 75.00 Quite High
cva 4 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Colon Cancer 16 96.96 Very High Very High Very High
Cancer 13 87.68 High High
Gastrointestinal Neoplasms 1 75.00 Quite High
Toxicity 24 5.00 Very Low Very Low Very Low
Diarrhoea 21 5.00 Very Low Very Low Very Low
Metastasis 13 5.00 Very Low Very Low Very Low
Disease 12 5.00 Very Low Very Low Very Low
Vomiting 11 5.00 Very Low Very Low Very Low
Death 4 5.00 Very Low Very Low Very Low
Cv General 3 Under Development 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Gemcitabine acts synergistically with fluoropyrimidines to enhance the binding of thymidylate synthase and increase inhibition of DNA synthesis.
Positive_regulation (enhance) of thymidylate synthase Binding (binding) of
1) Confidence 0.45 Published 2009 Journal Expert Opin Investig Drugs Section Abstract Doc Link 19678797 Disease Relevance 0.34 Pain Relevance 0.07
Of these treatments, fluoropyrimidines are the most often used and best investigated drugs [2,3]. 5-Fluorouracil (5-FU)-based chemotherapy, – usually biomodulated with folinic acid (FA) to increase its affinity for thymidylate synthase [4] -, was associated with an approximate doubling of the median survival compared to routine standard of care [5].
Positive_regulation (increase) of thymidylate synthase Binding (affinity) of
2) Confidence 0.02 Published 2004 Journal BMC Cancer Section Body Doc Link PMC497044 Disease Relevance 0.30 Pain Relevance 0

General Comments

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