INT162272

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Context Info
Confidence 0.14
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.34
Pain Relevance 0.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (KITLG) signal transduction (KITLG) extracellular space (KITLG)
extracellular region (KITLG) cell adhesion (KITLG) plasma membrane (KITLG)
Anatomy Link Frequency
stem cell 4
pigmentation 2
KITLG (Homo sapiens)
Pain Link Frequency Relevance Heat
melanocortin 1 receptor 78 83.72 Quite High
Inflammation 4 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Enkephalin 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
medulla 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 2 99.18 Very High Very High Very High
Reprotox - General 3 1 89.08 High High
Piedra 8 71.48 Quite High
Apoptosis 1 49.32 Quite Low
Alopecia 1 47.80 Quite Low
Hypopigmentation 11 5.00 Very Low Very Low Very Low
Contagious Ecthyma 6 5.00 Very Low Very Low Very Low
Hyperplasia 5 5.00 Very Low Very Low Very Low
INFLAMMATION 4 5.00 Very Low Very Low Very Low
Aids-related Complex 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The K14-SCF transgenic murine model of variant pigmentation is based on epidermal expression of stem cell factor (SCF) on the C57BL/6J background.
Regulation (based) of Gene_expression (expression) of SCF in stem cell associated with targeted disruption
1) Confidence 0.14 Published 2009 Journal Pigment Cell Melanoma Res Section Abstract Doc Link 19682281 Disease Relevance 0.18 Pain Relevance 0.07
These authors discovered the relevant locus controlling lighter pigmentation to be due to cis-regulatory changes affecting expression of the gene, kit ligand (kitl).
Regulation (affecting) of Gene_expression (expression) of kitl in pigmentation
2) Confidence 0.08 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2603666 Disease Relevance 0.07 Pain Relevance 0.35
Ghrelin has been shown to specifically inhibit the proliferative activity of immature Leydig cells by down-regulating stem cell factor (SCF) gene expression [39].
Regulation (regulating) of Gene_expression (expression) of SCF in stem cell
3) Confidence 0.06 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1291400 Disease Relevance 0.09 Pain Relevance 0

General Comments

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