INT162273

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Context Info
Confidence 0.13
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.30
Pain Relevance 0.17

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cytoplasm (KITLG, Tyr) cell proliferation (KITLG, Tyr) pigmentation (Tyr)
extracellular space (KITLG) signal transduction (KITLG) extracellular region (KITLG)
Anatomy Link Frequency
tail 3
ears 1
KITLG (Homo sapiens)
Tyr (Mus musculus)
Pain Link Frequency Relevance Heat
melanocortin 1 receptor 2 85.88 High High
Disease Link Frequency Relevance Heat
Targeted Disruption 4 83.32 Quite High
Aging 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, K14-SCF Tyr(c2j/c2j) animals demonstrated tyrosinase expression and enzymatic activity, suggesting that the c2j Tyr defect can be rescued in part by SCF in the ears and tail.
SCF Negative_regulation (rescued) of Gene_expression (defect) of Tyr in tail
1) Confidence 0.13 Published 2009 Journal Pigment Cell Melanoma Res Section Abstract Doc Link 19682281 Disease Relevance 0.15 Pain Relevance 0.09
Furthermore, K14-SCF Tyr(c2j/c2j) animals demonstrated tyrosinase expression and enzymatic activity, suggesting that the c2j Tyr defect can be rescued in part by SCF in the ears and tail.
SCF Negative_regulation (rescued) of in ears Gene_expression (defect) of Tyr in tail
2) Confidence 0.04 Published 2009 Journal Pigment Cell Melanoma Res Section Abstract Doc Link 19682281 Disease Relevance 0.15 Pain Relevance 0.09

General Comments

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