INT162284

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Context Info
Confidence 0.29
First Reported 2008
Last Reported 2010
Negated 0
Speculated 3
Reported most in Body
Documents 3
Total Number 6
Disease Relevance 1.78
Pain Relevance 1.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (Map2) intracellular (Map2) protein complex (Map2)
cytoplasm (Map2)
Anatomy Link Frequency
proximal 1
hippocampus 1
Map2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
fluoxetine 26 98.98 Very High Very High Very High
Hippocampus 10 98.96 Very High Very High Very High
ischemia 183 98.80 Very High Very High Very High
medulla 123 98.44 Very High Very High Very High
depression 5 95.64 Very High Very High Very High
agonist 15 92.40 High High
Glutamate 7 75.84 Quite High
anesthesia 6 75.32 Quite High
5HT 45 73.24 Quite High
Pyramidal cell 21 64.88 Quite High
Disease Link Frequency Relevance Heat
Stress 14 99.46 Very High Very High Very High
Cv Unclassified Under Development 147 98.80 Very High Very High Very High
Depression 5 95.64 Very High Very High Very High
Recurrence 1 95.08 Very High Very High Very High
Peripheral Arterial Disease 3 65.32 Quite High
Death 36 50.00 Quite Low
Transient Ischemic Attack 30 50.00 Quite Low
Sleep Disorders 6 45.36 Quite Low
Convulsion 6 39.92 Quite Low
Cv General 4 Under Development 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
m-thick sections were examined by immunostaining for microtubule-associated protein 2 (MAP2), IBA-1 and glial fibrillary acidic protein (GFAP).
microtubule-associated protein 2 Spec (examined) Binding (immunostaining) of
1) Confidence 0.29 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2949765 Disease Relevance 0.21 Pain Relevance 0.24
m-thick sections were examined by immunostaining for microtubule-associated protein 2 (MAP2), IBA-1 and glial fibrillary acidic protein (GFAP).
MAP2 Spec (examined) Binding (immunostaining) of
2) Confidence 0.29 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2949765 Disease Relevance 0.21 Pain Relevance 0.24
Ischemic lesions detected by immunostaining for MAP2 expanded further (Figure 5A-D).
MAP2 Binding (immunostaining) of
3) Confidence 0.29 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2949765 Disease Relevance 0.15 Pain Relevance 0.15
We investigated the effects of CUMS, fluoxetine and re-exposure to CUMS on alpha-tubulin isoforms associated with microtubule dynamics, MAP-2 and phospho-MAP-2 in the hippocampus of rats.
MAP-2 Binding (associated) of in hippocampus associated with stress, hippocampus and fluoxetine
4) Confidence 0.23 Published 2009 Journal Behav. Brain Res. Section Abstract Doc Link 19683020 Disease Relevance 1.20 Pain Relevance 0.39
Only a very small fraction colocalized with the dendritic marker Map2, which applied mainly to cell bodies and proximal dendrites (Fig. 1B).
Map2 Binding (colocalized) of in proximal
5) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2810327 Disease Relevance 0 Pain Relevance 0.07
Thus, we speculate that 5-HT2 receptors might activate ERK, leading to increased phosphorylation of MAP2 and its association with microtubules.
MAP2 Spec (might) Binding (association) of
6) Confidence 0.11 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2427346 Disease Relevance 0 Pain Relevance 0.25

General Comments

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