INT162307

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.23
First Reported 2009
Last Reported 2009
Negated 0
Speculated 1
Reported most in Abstract
Documents 2
Total Number 5
Disease Relevance 2.89
Pain Relevance 3.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Mapk4) cell cycle (Mapk4) cytoplasm (Mapk4)
Anatomy Link Frequency
neuronal 1
spinal cord 1
astrocytes 1
Mapk4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dorsal horn neuron 6 99.36 Very High Very High Very High
intrathecal 6 99.02 Very High Very High Very High
hyperexcitability 12 98.14 Very High Very High Very High
allodynia 9 97.52 Very High Very High Very High
Spinal cord 12 96.44 Very High Very High Very High
Thalamus 6 95.36 Very High Very High Very High
wide dynamic range 9 87.04 High High
induced neuropathy 4 83.52 Quite High
Hyperalgesia 4 77.12 Quite High
Kinase C 2 75.00 Quite High
Disease Link Frequency Relevance Heat
Injury 3 97.68 Very High Very High Very High
Neuropathic Pain 15 97.52 Very High Very High Very High
Urological Neuroanatomy 6 95.68 Very High Very High Very High
Hyperalgesia 8 84.64 Quite High
Nociception 2 80.32 Quite High
Frailty 6 75.00 Quite High
Peripheral Neuropathy 2 64.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study, we examined whether activation of p-38alpha MAPK modulates mechanical allodynia and neuronal hyperexcitability, and if propentofylline (PPF, a glial modulator) modulates specifically localized activated p-38alpha MAPK expression in caudal regions remote from a low thoracic hemisection injury in rats.
Gene_expression (expression) of p-38alpha MAPK in neuronal associated with allodynia, injury and hyperexcitability
1) Confidence 0.23 Published 2009 Journal Exp. Neurol. Section Abstract Doc Link 19699199 Disease Relevance 0.43 Pain Relevance 0.58
Intrathecal application of PPF significantly attenuated the expression of phosphorylated p-38alpha MAPK in superficial dorsal horn neurons (10 mM) and in microglia (1 and 10 mM) in the lumbar spinal cord compared to the hemisection group (p<0.05).
Gene_expression (expression) of p-38alpha MAPK in spinal cord associated with dorsal horn neuron, spinal cord and intrathecal
2) Confidence 0.23 Published 2009 Journal Exp. Neurol. Section Abstract Doc Link 19699199 Disease Relevance 0.34 Pain Relevance 0.81
After T13 spinal hemisection, significantly increased phosphorylated (activated form) p-38alpha MAPK expression was present in both superficial and deep dorsal horn neurons as well as in microglia, but not in astrocytes, in the lumbar spinal cord compared to sham controls (p<0.05).
Gene_expression (expression) of p-38alpha MAPK in astrocytes associated with dorsal horn neuron and spinal cord
3) Confidence 0.20 Published 2009 Journal Exp. Neurol. Section Abstract Doc Link 19699199 Disease Relevance 0.38 Pain Relevance 0.79
Distinct PKC-activated MAPK pathways, including p38MAPK, ERK1/2 and JNK, were investigated in chronic oxaliplatin rat.
Spec (investigated) Gene_expression (pathways) of p38MAPK
4) Confidence 0.06 Published 2009 Journal Pain Section Abstract Doc Link 19683395 Disease Relevance 0.87 Pain Relevance 0.63
Distinct PKC-activated MAPK pathways, including p38MAPK, ERK1/2 and JNK, were investigated in chronic oxaliplatin rat.
Gene_expression (/) of p38MAPK
5) Confidence 0.06 Published 2009 Journal Pain Section Abstract Doc Link 19683395 Disease Relevance 0.87 Pain Relevance 0.63

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox