INT162328

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Context Info
Confidence 0.19
First Reported 2005
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 21
Total Number 22
Disease Relevance 12.07
Pain Relevance 5.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Ptges2) cytosol (Ptges2) mitochondrion (Ptges2)
Golgi apparatus (Ptges2) nucleus (Ptges2) DNA binding (Ptges2)
Anatomy Link Frequency
fibroblasts 2
endothelial cells 1
Ptges2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 471 99.84 Very High Very High Very High
Arthritis 97 99.84 Very High Very High Very High
Inflammatory stimuli 22 97.40 Very High Very High Very High
cytokine 111 96.04 Very High Very High Very High
withdrawal 16 95.96 Very High Very High Very High
Central nervous system 24 95.04 Very High Very High Very High
Inflammatory response 11 94.44 High High
dexamethasone 8 92.68 High High
Hyperalgesia 9 91.96 High High
Neuropathic pain 8 91.04 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 498 99.84 Very High Very High Very High
Arthritis 97 99.84 Very High Very High Very High
Cancer 193 99.32 Very High Very High Very High
Colon Cancer 39 98.08 Very High Very High Very High
Disease 109 97.04 Very High Very High Very High
Nociception 8 96.48 Very High Very High Very High
Periodontitis 153 96.36 Very High Very High Very High
Fever 33 95.84 Very High Very High Very High
Cyst 22 94.52 High High
Hyperalgesia 9 91.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pharmacologically targeting mPGES-1 may not predispose patients at risk to airway dysfunction.
Regulation (targeting) of mPGES-1
1) Confidence 0.19 Published 2010 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 20371706 Disease Relevance 0.10 Pain Relevance 0.05
The differences in promoter structure and timing of induction suggest that divergent transcriptional mechanisms are responsible for the inducible regulation of COX-2 and mPGES-1.
Regulation (regulation) of mPGES-1
2) Confidence 0.17 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174970 Disease Relevance 0.18 Pain Relevance 0.11
However, upon injection with LPS, these animals show up-regulation of mPGES-1 in most tissues and markedly increased PGE2 production [9-11].
Regulation (regulation) of mPGES-1
3) Confidence 0.17 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174970 Disease Relevance 0.45 Pain Relevance 0.19
Animal pyresis models show transient up-regulation of mPGES-1 mRNA in brain endothelial cells after systemic injection with endotoxin or IL-1 [18,19].
Regulation (regulation) of mPGES-1 in endothelial cells
4) Confidence 0.17 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174970 Disease Relevance 1.36 Pain Relevance 0.54
Similar to COX-2, mPGES-1 is highly up-regulated by proinflammatory stimuli and participates in the generation of elevated PGE2 in inflammation.
Regulation (regulated) of mPGES-1 associated with inflammation
5) Confidence 0.12 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174970 Disease Relevance 1.07 Pain Relevance 0.84
In rat paws of acute (carrageenan-induced) and chronic (adjuvant-induced) arthritis models, significant up-regulation of mPGES-1 RNA and protein expression was observed, compared with other PGE synthases, and was also associated with elevated PGE2 levels [9,12,13].
Regulation (regulation) of mPGES-1 associated with arthritis
6) Confidence 0.12 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174970 Disease Relevance 0.60 Pain Relevance 0.21
To date, few studies have addressed signal transduction mechanisms responsible for up-regulation of mPGES-1 in arthritis.
Regulation (regulation) of mPGES-1 associated with arthritis
7) Confidence 0.12 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174970 Disease Relevance 0.91 Pain Relevance 0.56
The focus of this article is to review some recent advances in our understanding of mechanisms specific to the regulation of inducible mPGES-1 in inflammatory arthritis.



Regulation (regulation) of mPGES-1 associated with inflammation and arthritis
8) Confidence 0.07 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1174970 Disease Relevance 0.37 Pain Relevance 0.28
Regulation of mPGES-1
Regulation (Regulation) of mPGES-1
9) Confidence 0.07 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174970 Disease Relevance 1.01 Pain Relevance 0.82
Our data suggest that inhibition of mPGES-1 protein expression in acute and chronic inflammatory models by BTH, could provide a potential therapeutic target and a pharmacological tool to discern the role of the inducible enzymes COX-2 and mPGES-1 in inflammatory pathologies.
Regulation (role) of mPGES-1 associated with inflammation
10) Confidence 0.03 Published 2009 Journal Eur. J. Pharmacol. Section Abstract Doc Link 19686718 Disease Relevance 0.55 Pain Relevance 0.45
The expression and regulation of mPGES-1 share many similarities with that of COX-2, e.g. induced by pro-inflammatory stimuli and hormones [50].
Regulation (regulation) of mPGES-1 associated with inflammatory stimuli
11) Confidence 0.02 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1657027 Disease Relevance 0.71 Pain Relevance 0.07
B in the regulation of mPGES-1, COX-2 and PGE2, an additional inhibitor of NF-?
Regulation (regulation) of mPGES-1
12) Confidence 0.01 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2873473 Disease Relevance 0.29 Pain Relevance 0.06
B in mPGES-1 and COX-2 regulation
Regulation (regulation) of mPGES-1
13) Confidence 0.01 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2873473 Disease Relevance 0 Pain Relevance 0
To further explore the regulation of mPGES-1 and related PGE2-synthesizing enzymes in gingival fibroblasts, we here used a global gene expression profiling approach to achieve a broader view of the genes and signal pathways related to the regulation of mPGES-1, in parallel with COX-2, using microarray analysis of TNF?
Regulation (regulation) of mPGES-1 in fibroblasts
14) Confidence 0.01 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2873473 Disease Relevance 0.27 Pain Relevance 0.08
In this work, we therefore aim to explore the signal transduction pathways involved in the regulation of PGE2-regulating enzymes mPGES-1 and COX-2 in TNF?
Regulation (regulation) of mPGES-1
15) Confidence 0.01 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2873473 Disease Relevance 0.48 Pain Relevance 0.27
In this work, we therefore aim to explore the signal transduction pathways involved in the regulation of PGE2-regulating enzymes mPGES-1 and COX-2 in TNF?
Regulation (regulating) of mPGES-1
16) Confidence 0.01 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2873473 Disease Relevance 0.48 Pain Relevance 0.26
Involvement of JNK in the regulation of mPGES-1 and COX-2
Regulation (regulation) of mPGES-1
17) Confidence 0.01 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2873473 Disease Relevance 0 Pain Relevance 0
In this study we aimed to investigate the signal transduction pathways involved in the regulation of mPGES-1, COX-2 and PGE2 in TNF?
Spec (investigate) Regulation (regulation) of mPGES-1
18) Confidence 0.01 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2873473 Disease Relevance 0.43 Pain Relevance 0.18
The differences between cell types and between stimuli make it imperative to study the intracellular regulation of mPGES-1 as well as COX-2 using a cell type and stimulus which is relevant to the disease of interest.
Regulation (regulation) of mPGES-1 associated with disease
19) Confidence 0.01 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2873473 Disease Relevance 0.59 Pain Relevance 0.31
B pathway was involved in the regulation of mPGES-1 and COX-2 in gingival fibroblasts stimulated with TNF?.
Regulation (regulation) of mPGES-1 in fibroblasts
20) Confidence 0.01 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2873473 Disease Relevance 0.56 Pain Relevance 0.23

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