INT162339

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Context Info
Confidence 0.32
First Reported 2005
Last Reported 2009
Negated 2
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.42
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (SOX9) nucleolus (SOX9) nucleus (SOX9)
extracellular matrix organization (SOX9) protein complex assembly (SOX9) protein complex (SOX9)
SOX9 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 3 10.00 Low Low
cytokine 10 9.04 Low Low
metalloproteinase 9 5.00 Very Low Very Low Very Low
backache 7 5.00 Very Low Very Low Very Low
agonist 6 5.00 Very Low Very Low Very Low
antagonist 5 5.00 Very Low Very Low Very Low
Nerve growth factor 3 5.00 Very Low Very Low Very Low
Osteoarthritis 3 5.00 Very Low Very Low Very Low
Chronic low back pain 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Peripheral Arterial Disease 51 99.84 Very High Very High Very High
Stress 7 96.92 Very High Very High Very High
Osteogenic Sarcomas 5 78.20 Quite High
Aging 5 46.96 Quite Low
Intervertebral Disk Degeneration 10 5.00 Very Low Very Low Very Low
Low Back Pain 9 5.00 Very Low Very Low Very Low
Osteoarthritis 6 5.00 Very Low Very Low Very Low
Injury 4 5.00 Very Low Very Low Very Low
Intervertebral Disk Displacement 4 5.00 Very Low Very Low Very Low
Disease 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
No real effect was observed on SOX6 and SOX9 gene expression in cells derived from degenerate discs (Fig. 5a,b).
Regulation (observed) of Gene_expression (expression) of SOX9
1) Confidence 0.32 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175026 Disease Relevance 0 Pain Relevance 0
High expression of IHH and Sox9 were not related to any clinicopathological parameters.
Neg (not) Regulation (related) of Gene_expression (expression) of Sox9
2) Confidence 0.21 Published 2009 Journal Tumori Section Body Doc Link 19688969 Disease Relevance 0.08 Pain Relevance 0
Hardingham, unpublished data) and, although there was no direct effect of FGF-2 expansion on SOX9 expression in IPFP-derived cells in monolayer, it may have suppressed subsequent actin stress fibre formation during chondrogenesis.
Neg (no) Regulation (effect) of Gene_expression (expression) of SOX9 associated with stress and peripheral arterial disease
3) Confidence 0.12 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575620 Disease Relevance 0.34 Pain Relevance 0
Zhang et al. studied the effects of several bone morphogenetic proteins (BMPÂ’s) and Sox-9 transfection on AF cells.
Regulation (effects) of Gene_expression (transfection) of Sox-9
4) Confidence 0.05 Published 2008 Journal Eur Spine J Section Body Doc Link PMC2899423 Disease Relevance 0 Pain Relevance 0

General Comments

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