INT162339

Context Info Confidence 0.32 First Reported 2005 Last Reported 2009 Negated 2 Speculated 0 Reported most in Body Documents 4 Total Number 4 Disease Relevance 0.42 Pain Relevance 0

signal transduction (SOX9) nucleolus (SOX9) nucleus (SOX9) extracellular matrix organization (SOX9) protein complex assembly (SOX9) protein complex (SOX9)

SOX9 (Homo sapiens)

Pain Link Frequency Relevance Heat Pain 3 10.00 cytokine 10 9.04 metalloproteinase 9 5.00 backache 7 5.00 agonist 6 5.00 antagonist 5 5.00 Nerve growth factor 3 5.00 Osteoarthritis 3 5.00 Chronic low back pain 2 5.00 Inflammation 2 5.00

Disease Link Frequency Relevance Heat Peripheral Arterial Disease 51 99.84 Stress 7 96.92 Osteogenic Sarcomas 5 78.20 Aging 5 46.96 Intervertebral Disk Degeneration 10 5.00 Low Back Pain 9 5.00 Osteoarthritis 6 5.00 Injury 4 5.00 Intervertebral Disk Displacement 4 5.00 Disease 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

No real effect was observed on SOX6 and SOX9 gene expression in cells derived from degenerate discs (Fig. 5a,b).

Regulation (observed) of Gene_expression (expression) of SOX9

1) Confidence 0.32 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175026 Disease Relevance 0 Pain Relevance 0

High expression of IHH and Sox9 were not related to any clinicopathological parameters.

Neg (not) Regulation (related) of Gene_expression (expression) of Sox9

2) Confidence 0.21 Published 2009 Journal Tumori Section Body Doc Link 19688969 Disease Relevance 0.08 Pain Relevance 0

Hardingham, unpublished data) and, although there was no direct effect of FGF-2 expansion on SOX9 expression in IPFP-derived cells in monolayer, it may have suppressed subsequent actin stress fibre formation during chondrogenesis.

Neg (no) Regulation (effect) of Gene_expression (expression) of SOX9 associated with stress and peripheral arterial disease

3) Confidence 0.12 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575620 Disease Relevance 0.34 Pain Relevance 0

Zhang et al. studied the effects of several bone morphogenetic proteins (BMP’s) and Sox-9 transfection on AF cells.

Regulation (effects) of Gene_expression (transfection) of Sox-9

4) Confidence 0.05 Published 2008 Journal Eur Spine J Section Body Doc Link PMC2899423 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.