INT16234

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Context Info
Confidence 0.50
First Reported 1980
Last Reported 2010
Negated 0
Speculated 3
Reported most in Body
Documents 25
Total Number 33
Disease Relevance 26.05
Pain Relevance 3.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CFH) extracellular region (CFH)
Anatomy Link Frequency
parasympathetic 2
neuron 1
plaque 1
sympathetic 1
germ cell 1
CFH (Homo sapiens)
Pain Link Frequency Relevance Heat
narcan 7 98.66 Very High Very High Very High
Pain 8 96.08 Very High Very High Very High
imagery 7 93.56 High High
aspirin 3 93.40 High High
abdominal pain 3 92.24 High High
cINOD 6 91.20 High High
metalloproteinase 2 90.92 High High
Angina 3 90.52 High High
Morphine 3 86.24 High High
ischemia 1 86.08 High High
Disease Link Frequency Relevance Heat
Hemolytic Uremic Syndrome 108 100.00 Very High Very High Very High
Renal Disease 39 100.00 Very High Very High Very High
Infection 89 99.98 Very High Very High Very High
Hypercapnia 3 99.98 Very High Very High Very High
Insulin Resistance 23 99.52 Very High Very High Very High
Thrombocytopenia 11 99.52 Very High Very High Very High
Hypoxia 160 98.78 Very High Very High Very High
Ectopic Pregnancy 15 98.66 Very High Very High Very High
Cancer 21 98.62 Very High Very High Very High
Diarrhoea 44 98.54 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This was expected, because the hybrid CFH/CFHL1 gene described here would not be picked up by genomic sequencing using CFH-specific primers

CFH cDNA Sequencing

Positive_regulation (hybrid) of CFH
1) Confidence 0.50 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1626556 Disease Relevance 0.14 Pain Relevance 0
We hypothesised that the crossover responsible for deletion of CFHL1 could also potentially result in formation of a CFH/CFHL1 hybrid gene.
Positive_regulation (formation) of CFH
2) Confidence 0.50 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1626556 Disease Relevance 0.23 Pain Relevance 0
Another supporting study showed that the activation of CFH is greater in the superficial rather than the deeper layer of the atherosclerotic plaque [2].
Positive_regulation (activation) of CFH in plaque associated with atherosclerotic plaque
3) Confidence 0.47 Published 2007 Journal BMC Med Genet Section Body Doc Link PMC2048938 Disease Relevance 0.80 Pain Relevance 0.11
CFH and FHL1 are both encoded by the human CFH gene and are derived by alternative splicing [13]–[15].
Positive_regulation (derived) of CFH
4) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2958145 Disease Relevance 0.82 Pain Relevance 0.10
Activation of the alternative pathway of the complement system, in which factor H (fH; complement fH [CFH]) is a key regulatory component, has been suggested as a link between obesity and metabolic disorders.
Positive_regulation (Activation) of factor H associated with metabolic disorder and obesity
5) Confidence 0.45 Published 2010 Journal Diabetes Section Abstract Doc Link PMC2797922 Disease Relevance 0.78 Pain Relevance 0
However, other work suggested that in some families with aHUS, simple genetic mutations might not be the cause; instead more complicated rearrangements of the genome might occur which would then result in an abnormal factor H that incorporated part of the gene for another protective protein called factor H related protein 1.


Positive_regulation (incorporated) of factor H
6) Confidence 0.44 Published 2006 Journal PLoS Medicine Section Abstract Doc Link PMC1626556 Disease Relevance 0.48 Pain Relevance 0
This was a recurrent case of HUS induced by pranoprofen.
Positive_regulation (induced) of HUS associated with hemolytic uremic syndrome
7) Confidence 0.39 Published 1999 Journal Rinsho Ketsueki Section Abstract Doc Link 10496042 Disease Relevance 1.07 Pain Relevance 0.08
Recognition of a drug-induced HUS is necessary to avoid reexposure and recurrent HUS.
Positive_regulation (induced) of HUS associated with hemolytic uremic syndrome
8) Confidence 0.39 Published 2007 Journal Clin. Nephrol. Section Abstract Doc Link 17915621 Disease Relevance 1.14 Pain Relevance 0.17
Ibuprofen-induced HUS.
Positive_regulation (induced) of HUS associated with hemolytic uremic syndrome
9) Confidence 0.39 Published 2007 Journal Clin. Nephrol. Section Title Doc Link 17915621 Disease Relevance 1.17 Pain Relevance 0.17
Early ectopic pregnancy screening using vaginal ultrasonographic technology together with measurement of beta human chorionic gonadotropin (beta-hCG) and human chorionic somatomammotropin is possible within the first 2 weeks of the missing menses, prior to the appearance of symptoms.
Positive_regulation (measurement) of beta-hCG associated with ectopic pregnancy
10) Confidence 0.38 Published 1991 Journal Curr. Opin. Obstet. Gynecol. Section Abstract Doc Link 1813010 Disease Relevance 0.23 Pain Relevance 0.04
Twelve patients received antilymphocyte globulin, and seven patients received a low dose of steroids before the MR diagnosis of osteonecrosis.
Positive_regulation (received) of antilymphocyte globulin associated with aseptic necrosis of bone
11) Confidence 0.35 Published 2002 Journal J. Korean Med. Sci. Section Abstract Doc Link 12483006 Disease Relevance 1.10 Pain Relevance 0.21
After washing, equimolar amounts (33 µM) of CFH, CFHR1, CFHR2 or CFHR5 were added and incubated for 1 h at RT.
Positive_regulation (incubated) of CFH
12) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2958145 Disease Relevance 0 Pain Relevance 0
This is accomplished, at least in part, by the spirochetes camouflaging their outer surface with host-derived complement factor H (CFH) and factor H-like protein 1 (FHL1) which are fluid-phase immune regulators of the alternative complement pathway [9]–[12].
Positive_regulation (derived) of CFH
13) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2958145 Disease Relevance 1.05 Pain Relevance 0.14
This is accomplished, at least in part, by the spirochetes camouflaging their outer surface with host-derived complement factor H (CFH) and factor H-like protein 1 (FHL1) which are fluid-phase immune regulators of the alternative complement pathway [9]–[12].
Positive_regulation (derived) of factor H-like protein 1
14) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2958145 Disease Relevance 1.05 Pain Relevance 0.14
The ectopic group comprised 22 patients, all of whom had elevated beta-hCG levels.
Positive_regulation (elevated) of beta-hCG
15) Confidence 0.32 Published 1980 Journal Obstet Gynecol Section Abstract Doc Link 7393509 Disease Relevance 0.89 Pain Relevance 0.14
The rate of attenuation of tissue sensitivity to naloxone was measured and no changes were observed after incubation in the presence of monkey antimorphine globulin.
Positive_regulation (presence) of antimorphine globulin associated with narcan
16) Confidence 0.32 Published 1981 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7194910 Disease Relevance 0.26 Pain Relevance 0.70
Since the beta-human chorionic gonadotropin (beta-hCG) level was increased to 20.46 mIU/ml on the preoperative blood test, incisional biopsy was performed through a Chamberlain incision to rule out the mediastinal germ cell tumors.
Positive_regulation (increased) of beta-hCG in germ cell associated with germ cell and embryonal neoplasms
17) Confidence 0.31 Published 2010 Journal Interact Cardiovasc Thorac Surg Section Abstract Doc Link 20421278 Disease Relevance 0.35 Pain Relevance 0.09
CFH and FHL1 are both encoded by the human CFH gene and are derived by alternative splicing [13]–[15].
Positive_regulation (derived) of CFH
18) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2958145 Disease Relevance 0.79 Pain Relevance 0.10
This is accomplished, at least in part, by the spirochetes camouflaging their outer surface with host-derived complement factor H (CFH) and factor H-like protein 1 (FHL1) which are fluid-phase immune regulators of the alternative complement pathway [9]–[12].
Positive_regulation (derived) of complement factor H
19) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2958145 Disease Relevance 1.05 Pain Relevance 0.14
CONCLUSION: Early diagnosis of intramural pregnancy by skipped menstruation, elevated beta human chorionic gonadotropin (beta-hCG) and intramural cyst not connected the with the endometrium and with no other possible sites of ectopic pregnancy allows the clinician to plan the conservative treatment method at the optimum time, with more opportunity for conservation of fertility.


Positive_regulation (elevated) of beta-hCG in endometrium
20) Confidence 0.28 Published 2009 Journal J Reprod Med Section Body Doc Link 19438169 Disease Relevance 0.08 Pain Relevance 0

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