INT162359

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Context Info
Confidence 0.18
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.94
Pain Relevance 1.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (KRT32)
Anatomy Link Frequency
plasma 1
KRT32 (Homo sapiens)
Pain Link Frequency Relevance Heat
bradykinin 36 100.00 Very High Very High Very High
Pain 3 95.84 Very High Very High Very High
Inflammation 3 92.80 High High
agonist 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sprains And Strains 12 98.48 Very High Very High Very High
Influenza Virus Infection 33 98.16 Very High Very High Very High
Pain 3 95.84 Very High Very High Very High
INFLAMMATION 3 92.80 High High
Hypertension 3 91.68 High High
Endotoxemia 3 90.56 High High
Infection 17 90.40 High High
Coagulation Disorder 3 89.20 High High
Hereditary Angioedema 3 69.44 Quite High
Pressure And Volume Under Development 3 58.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Systemic production of BK, HKa with the interplay between BK bound-BK receptors and the soluble form of HKa are key to angiogenesis and hemodynamics.
Gene_expression (production) of HKa associated with bradykinin
1) Confidence 0.18 Published 2009 Journal Cardiovascular & hematological agents in medicinal chemistry Section Abstract Doc Link 19689262 Disease Relevance 0.55 Pain Relevance 0.56
The conversion of plasma prekallikrein to kallikrein by the activated FXII and in response to numerous different stimuli leads to the generation of bradykinin (BK) and activated HK (HKa, an antiangiogenic peptide).
Gene_expression (generation) of HKa in plasma associated with bradykinin
2) Confidence 0.14 Published 2009 Journal Cardiovascular & hematological agents in medicinal chemistry Section Abstract Doc Link 19689262 Disease Relevance 0.37 Pain Relevance 0.46
Systemic production of BK, HKa with the interplay between BK bound-BK receptors and the soluble form of HKa are key to angiogenesis and hemodynamics.
Gene_expression (production) of HKa associated with bradykinin
3) Confidence 0.14 Published 2009 Journal Cardiovascular & hematological agents in medicinal chemistry Section Abstract Doc Link 19689262 Disease Relevance 0.59 Pain Relevance 0.60
In the current study, we found that expression and purification of properly folded H1N1 HA1 (1–330) (lacking HA2) in bacterial system was more efficient and gave higher yield compared with the larger HA ectodomain (1–480).
Gene_expression (expression) of HA2
4) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2902520 Disease Relevance 0.43 Pain Relevance 0

General Comments

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